6-Chloro-5-methyl-pyridine-2-amine

6-Chloro-5-methyl-pyridine-2-amine, this is a kind of organic compound. Looking at its name, we can know the outline of its chemical structure.
"Pyridine" is a nitrogen-containing six-membered heterocyclic compound with aromatic properties. Take pyridine as the parent structure and introduce different substituents at specific positions on its ring to obtain this compound.
"6-chloro" means that at the 6th position of the pyridine ring, there is a chlorine atom attached. The chlorine atom is a halogen element with certain electronegativity, which affects the physical and chemical properties of the compound. It can affect the polarity, boiling point and other physical properties of molecules. In chemical reactions, chlorine atoms are also often active check points, which can participate in many reactions such as substitution and elimination.
"5-methyl" is connected with methyl group (-CH 🥰) at position 5 of the pyridine ring. Methyl group is the power supply group, and its introduction can change the electron cloud density distribution of the pyridine ring, which in turn affects the reactivity and selectivity of the compound.
"2-amine" indicates that there is an amino group (-NH -2) connected at position 2 of the pyridine ring. Amino groups are basic and can react with acids to form salts. In organic synthesis, amino groups are also important reaction check points and can participate in many organic reactions, such as amidation and alkylation.
In summary, the chemical structure of 6-chloro-5-methyl-pyridine-2-amine is based on the pyridine ring as the core, with chlorine atom at position 6, methyl at position 5, and amino at position 2. This unique structure endows the compound with specific physical and chemical properties, which has important research and application value in organic synthesis and related fields.

6-Chloro-5-methyl-pyridine-2-amine is one of the organic compounds. It has many important physical properties, so let me tell them one by one.
Looking at its properties, under room temperature and pressure, it is mostly white to light yellow solid powder. This form is conducive to storage and transportation, because it is relatively stable and not easy to flow or evaporate at will.
When it comes to melting point, it is usually within a specific range. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. The melting point of 6-chloro-5-methyl-pyridine-2-amine has been determined by many experiments to be around [X] ° C. This melting point characteristic is crucial in the process of organic synthesis and separation and purification. After synthesis, the melting point can be measured to test its purity. If the melting point of the sample matches or is similar to the known standard melting point, it indicates that its purity is quite high; if the melting point deviates greatly, it may contain impurities and needs to be further purified.
Furthermore, solubility is also one of its key properties. In common organic solvents, such as ethanol, dichloromethane, etc., it exhibits a certain solubility. In ethanol, moderate heating and stirring can better dissolve. This property is convenient for selecting a suitable solvent in the organic synthesis reaction to fully mix the reactants and promote the smooth progress of the reaction. However, in water, its solubility is relatively poor. This is due to the action of hydrophobic groups in the molecular structure, which makes the interaction with water molecules weak and difficult to disperse in water.
In addition, the density of this compound also has its specific value. The density is also the mass per unit volume. The density of 6-chloro-5-methyl-pyridine-2-amine is about [X] g/cm ³. This physical quantity is of great significance in the accurate calculation of material dosage in chemical production and laboratory operations, and in the control of reaction process and product quality. In conclusion, the physical properties of 6-chloro-5-methyl-pyridine-2-amine, such as properties, melting point, solubility, and density, play an indispensable role in the research, synthesis, and application of organic chemistry, providing an important basis for researchers and chemical practitioners.

6-Chloro-5-methylpyridine-2-amine, which is often a reactant in many reactions in organic synthesis. It plays a key role in the construction of nitrogen-containing heterocycles. The presence of pyridine rings with amino and chlorine atoms endows it with unique reactivity.
For example, in nucleophilic substitution reactions, chlorine atoms are active and easily replaced by nucleophilic reagents. If reacted with sodium alcohol, corresponding ether derivatives can be formed. This reaction realizes the construction of carbon-oxygen bonds by the attack of nucleophilic reagents on chlorine atoms. In drug synthesis, it is often a means of introducing specific functional groups.
In the metal-catalyzed coupling reaction, 6-chloro-5-methylpyridine-2-amine can be used as a substrate. Taking the coupling reaction catalyzed by palladium as an example, it is coupled with aryl halides under the action of suitable ligands and bases to realize the connection between pyridine rings and aryl groups, and expand the conjugate system of molecules. This is of great significance in the field of materials chemistry for the preparation of materials with special photoelectric properties.
In the reaction of amine groups, it can acylate with acyl chloride, acid anhydride, etc., to form amide compounds. This reaction is widely used in the construction of bioactive molecules and the preparation of polymer materials. Because of the stable amide bond and diverse biological activities and material properties, 6-chloro-5-methylpyridine-2-amine is frequently used as a reactant to promote the synthesis of many important compounds in various reactions of organic synthesis.

The synthesis of 6-chloro-5-methyl-pyridine-2-amine has been known for a long time. In the past, many paths were followed to prepare this substance.
One of them can be started by pyridine derivatives containing specific substituents. Chloride at specific positions on the pyridine ring with suitable halogenating reagents, such as thionyl chloride, phosphorus oxychloride, etc., and introduce chlorine atoms. Then, through a delicate methylation reaction, methylating reagents such as iodomethane, dimethyl sulfate, etc. are added to the suitable check point of the pyridine ring. As for the introduction of amino groups, or by means of nucleophilic substitution reactions, ammonia or amine compounds interact with the corresponding halogenated pyridine derivatives, and the reaction conditions, such as temperature, solvent, catalyst, etc., are carefully regulated to make the reaction proceed in the expected direction to obtain the target product.
Second, there are also pyridine-based, and a series of reactions are used to construct a suitable substitution mode. For example, first, a position on the pyridine ring is activated under suitable reaction conditions, which is convenient for subsequent nucleophilic reagents to attack. Then, after multi-step conversion, chlorine atoms, methyl groups and amine groups are introduced in an orderly manner. This process requires precise control of each reaction step, considering the selectivity, yield, and stability of the intermediate in each step.
Furthermore, some Fangjia have taken a different approach and adopted a metal catalysis strategy. Transition metal catalysts, such as palladium and copper, are used to catalyze the coupling reaction of halogenated pyridine derivatives with reagents containing methyl and amine groups. Although this method is delicate, it requires strict reaction conditions. It requires precise preparation of catalyst dosage, ligand structure, reaction temperature, time and other factors to efficiently synthesize 6-chloro-5-methyl-pyridine-2-amine.
All kinds of synthesis methods have their own advantages and disadvantages. They all depend on Fangjia to consider various factors such as materials, equipment, and cost according to actual needs, and choose the best one to achieve the purpose of synthesis.

6-Chloro-5-methylpyridine-2-amine is widely used in industrial production.
First, in the field of pharmaceutical synthesis, it is a key intermediate. The specific structure of the geinpyridine ring with amino groups, chlorine atoms and methyl groups endows the compound with unique reactivity and biological activity. With this as the starting material, through multi-step reactions, antibacterial drugs can be prepared. For example, specific pyridine amine antibacterial agents interact with key bacterial metabolic enzymes to interfere with the bacterial metabolic process and achieve antibacterial effect, providing a variety of options for pharmaceutical research and development, and helping to develop high-efficiency and low-toxicity antibacterial drugs.
Second, in the creation of pesticides, the effect is significant. It can be used as an important intermediate for the synthesis of new insecticides and fungicides. Because of its structure, it can precisely target the specific action targets of pests or bacteria, and has high selectivity and biological activity. For example, insecticides for some piercing oral pests, by binding to specific proteins of the pest's nervous system or digestive system, interfere with their normal physiological functions, achieve efficient insecticides, and have little impact on the environment and non-target organisms, promoting the development of green and environmentally friendly pesticides.
Third, in the field of materials science, it also has applications. It can participate in the synthesis of functional materials. For example, in the synthesis of organic optoelectronic materials, its structural properties can regulate the electronic transport and optical properties of materials. Introducing it into the conjugated polymer system can change the polymer energy level structure and charge mobility, improve the photoelectric conversion efficiency of organic solar cells, or improve the luminescence performance of organic Light Emitting Diodes, and contribute to the development and performance optimization of new functional materials.
In summary, 6-chloro-5-methylpyridine-2-amine has important applications in industrial production fields such as medicine, pesticides and materials science, and is of great significance for promoting technological progress and innovation in various fields.