6-Chloro-4-methylpyridine-3-boronic acid

6-Chloro-4-methylpyridine-3-boronic acid, this substance has a wide range of uses and is often a key intermediate in the field of organic synthesis.
First, it has many applications in the field of medicinal chemistry. Because of its unique chemical structure, it can be combined with many bioactive molecules to help build a novel drug molecular skeleton. By coupling with other compounds, compounds with specific pharmacological activities can be prepared, paving the way for the development of new drugs. For example, in the development of anti-tumor drugs, if cleverly designed to react with compounds containing specific functional groups, drugs that can target tumor cells may be obtained, precisely inhibiting the growth of tumor cells.
Second, it is also indispensable in materials science. It can participate in the construction of functional organic materials, such as for the preparation of optoelectronic materials. By rationally designing the reaction, the boric acid is introduced into the polymer structure, which may endow the material with unique optoelectronic properties, such as good fluorescence properties or high-efficiency charge transfer ability, which is of great value in the manufacture of organic Light Emitting Diode (OLED), solar cells and other devices.
Third, in the conventional reactions of organic synthetic chemistry, as a boric acid compound, it can participate in the Suzuki-Miyaura coupling reaction. This reaction is widely used. 6-chloro-4-methylpyridine-3-boronic acid can be coupled with halogenated aromatics, halogenated olefins and other substrates under the action of suitable catalysts and bases to realize the construction of carbon-carbon bonds. Organic compounds with complex and diverse structures are synthesized, which greatly enriches the strategies and means of organic synthesis.

The synthesis method of 6-chloro-4-methylpyridine-3-boronic acid, although the ancient book "Tiangong Kaiwu" does not directly describe the synthesis method of such compounds, it can be deduced according to the chemical process ideas contained in it.
First, we can start from boron-containing compounds and pyridine-containing structural halides. First find suitable boron sources, such as boranes or borate esters. Boranes have high activity and are often used as boronizing reagents in organic synthesis. Borate esters are relatively stable and easy to operate. At the same time, choose a pyridine halide containing a suitable substituent, this example is 6-chloro-4-methylpyridine-3-halide. Transition metals such as palladium or nickel are used as catalysts, and ligands are used to assist in the coupling reaction between boron sources and pyridine halides. This is a commonly used method in the synthesis of organoboron compounds, which is catalyzed by transition metals to promote the formation of carbon-boron bonds.
Second, or start with the construction of a pyridine skeleton. Pyridine with corresponding substituents is synthesized first, and then borate groups are introduced through boronation. Boron groups can be introduced at specific positions in the pyridine ring by using a suitable boronation agent. However, it is necessary to consider the influence of existing chlorine and methyl groups on the reactivity and selectivity of the pyridine ring. By adjusting the reaction conditions and selecting suitable catalysts and reagents, selective boronation can be achieved to obtain the target product 6-chloro-4-methylpyridine-3-boronic acid.

6-Chloro-4-methylpyridine-3-boronic acid, which is white to off-white solid. Its melting point range is about 244-248 ° C, which makes it have a clear temperature range when heated.
In terms of solubility, it is slightly soluble in water, and has better solubility in common organic solvents such as methanol and ethanol. This solubility makes it possible to choose suitable solvents in different reaction systems and separation processes.
From the perspective of chemical properties, its boric acid group has typical boric acid characteristics, which are weakly acidic and can react with alcohols under specific conditions to form borate esters. In the field of organic synthesis, this reaction is often used to protect hydroxyl groups or build complex organic structures. At the same time, the chlorine atoms in this compound have certain reactivity and can participate in nucleophilic substitution reactions, such as reacting with nitrogen and oxygen nucleophiles to derive various pyridine derivatives. In addition, due to the presence of pyridine rings, the whole molecule has a certain alkalinity and can form salts with acids. The combined effect of these physical and chemical properties makes 6-chloro-4-methylpyridine-3-boronic acid an important intermediate in organic synthesis in many fields such as pharmaceutical chemistry and materials science, which helps to create new compounds and develop functional materials.

6-Chloro-4-methylpyridine-3-boronic acid is a reagent commonly used in organic synthesis. When storing and transporting, pay attention to many matters.
First words storage, this compound should be placed in a dry, cool and well-ventilated place. Because of its certain hygroscopicity, if the storage environment humidity is quite high, it is easy to cause water absorption and deterioration, which will affect the effect of subsequent use. And it is necessary to keep away from fire and heat sources to prevent chemical reactions caused by heat, causing decomposition or other adverse changes.
Furthermore, it should be stored separately from oxidizing substances, acids, bases, etc. The chemical properties of 6-chloro-4-methylpyridine-3-boronic acid determine that when it comes into contact with the above substances, it is prone to chemical reactions, or dangerous conditions such as combustion and explosion. The storage container should also be selected appropriately. Generally, a sealed glass bottle or plastic bottle is appropriate to ensure good sealing and prevent air and moisture from invading.
As for transportation, it needs to be properly packaged. The packaging material should have good shock and moisture resistance to avoid damage to the container due to vibration and collision during transportation, resulting in compound leakage. The transportation process should also maintain the stability of the environment and avoid high temperature, high humidity and severe temperature changes. Transportation personnel should also be familiar with the characteristics of this compound and emergency treatment methods. In case of leakage and other emergencies, they can be disposed of in time and properly to prevent the harm from expanding. In this way, the safety and stability of 6-chloro-4-methylpyridine-3-boronic acid during storage and transportation can be ensured.

6-Chloro-4-methylpyridine-3-boronic acid is an important intermediate commonly used in organic synthesis. It is widely used in various fields such as medicine, pesticides and material science.
As for its market price, it is difficult to generalize. The price is affected by many factors, one of which is the production cost. To prepare this compound, the cost of raw materials is crucial. If the raw material is rare and expensive, the product price must be high. Furthermore, the complexity of the synthesis process also affects the cost. Complex processes require more steps, more refined equipment and higher technology, and the cost naturally increases.
The second is market supply and demand. If the market demand for 6-chloro-4-methylpyridine-3-boronic acid is strong and the supply is limited, the price will rise; conversely, if the supply is sufficient and the demand is weak, the price will tend to fall.
The third is product quality. High-purity products tend to be more expensive due to the complex purification process and high cost.
Looking at the market conditions in the past, the price of 6-chloro-4-methylpyridine-3-boronic acid supplied by different purity and different suppliers varies greatly. Those with slightly lower purity may cost tens of yuan per gram; while high-purity boutiques may cost more than 100 yuan per gram or even higher.
However, the market is changing, the price of raw materials fluctuates, new synthesis technologies emerge, and market demand increases or decreases, all of which will make its prices change in real time. To know the exact price, you need to consult relevant chemical product suppliers, trading platforms, or refer to recent market transaction data to get the current price.