6-Chloro-3-pyridinecarbonitrile

6-Chloro-3-pyriformonitrile has a wide range of uses. In the field of pharmaceutical synthesis, it is a key intermediate. In many drug development paths, it is necessary to use this as a starting material and undergo a series of delicate chemical reactions to construct complex compound structures with specific pharmacological activities. For example, in the creation process of some antibacterial drugs, the reaction steps involved in 6-chloro-3-pyriformonitrile play a decisive role in shaping the antibacterial efficacy and specific binding check point of drug molecules.
It also plays an important role in the field of pesticide chemistry. It is often used in the synthesis of highly efficient and low-toxicity pesticides, fungicides and other pesticide products. By ingeniously combining and reacting with other chemicals, the resulting pesticides can precisely act on specific physiological targets of pests or pathogens, achieving good control effects, while reducing the adverse effects on the environment and non-target organisms.
Furthermore, in the field of materials science, 6-chloro-3-pyridineformonitrile can be used as an important building block for the synthesis of special functional materials. Through a well-designed reaction process, it can be introduced into polymer or organic-inorganic hybrid materials, imparting unique physical and chemical properties such as fluorescence properties and enhanced chemical stability to the materials, thus meeting the special needs of materials in different fields such as photoelectric display and chemical sensing.

6-Chloro-3-pyridineformonitrile is also an important intermediate in organic synthesis. There are roughly several ways to synthesize it.
One is to use 3-cyanopyridine as the starting material. In a suitable reaction vessel, add 3-cyanopyridine and an appropriate amount of solvent, such as dichloromethane, to create a suitable reaction environment. Then, slowly add chlorinated reagents, such as N-chlorosuccinimide (NCS), and react at low temperature and under stirring conditions. In this process, the chlorine atom of the chlorinating reagent replaces the hydrogen atom at a specific position on the pyridine ring through a substitution reaction, resulting in 6-chloro-3-pyridyl formonitrile. Due to the characteristics of the electron cloud distribution on the pyridine ring, the hydrogen at a specific position has a certain activity and can be replaced by chlorine atoms.
The second is to use 6-hydroxy-3-pyridyl formonitrile as a raw material. First mix 6-hydroxy-3-pyridyl formonitrile with a suitable halogenating reagent, such as phosphorus oxychloride (POCl). Under the condition of heating, the halogenated reagent reacts with the hydroxyl group, and the hydroxyl group is replaced by the chlorine atom, and then the target product 6-chloro-3-pyridyl formonitrile is formed. The mechanism of this reaction is that the active chlorine atom and the hydroxyl group in the halogenated reagent form an intermediate state, and the purpose of the hydroxyl group being replaced by chlorine is achieved through a series of rearrangement and elimination steps.
Third, the corresponding pyridine derivatives can be started from the corresponding pyridine derivatives to construct cyano and chlorine atoms through a multi-step reaction. For example, a pyridine compound containing a suitable substituent is prepared first, and a cyano group is introduced by a nucleophilic substitution reaction, and then a Although there are many steps in this process, it can be flexibly adjusted according to the availability of raw materials and the selectivity of the reaction to achieve the purpose of synthesis. Each method has its advantages and disadvantages, and must be selected according to actual needs, such as the cost of raw materials, the difficulty of reaction, the purity of the product and other factors.

6-Chloro-3-pyridineformonitrile is an important compound in the field of organic chemistry. Its physical properties are crucial for many chemical and industrial applications.
Looking at its properties, under normal temperature and pressure, 6-chloro-3-pyridineformonitrile often appears as a white to pale yellow crystalline powder. This morphology is conducive to storage and transportation, because it is relatively stable, it is not easy to change significantly under conventional conditions.
When it comes to the melting point, the melting point of this compound is about 75-78 ° C. The characteristics of the melting point are of great significance for its phase transition under specific temperature conditions. In the vicinity of the melting point temperature, 6-chloro-3-pyridineformonitrile gradually melts from a solid state to a liquid state. This process can be used as an important reference for temperature control in the heating reaction step of organic synthesis. If the reaction temperature is close to or reaches its melting point, it is necessary to pay attention to the effect of changes in the state of the compound on the reaction process.
Besides solubility, 6-chloro-3-pyridineformonitrile is insoluble in water, but it has some solubility in organic solvents such as dichloromethane, chloroform, ethanol, acetone, etc. Its insoluble nature makes it easy to distinguish from water-soluble substances when it comes to reactions or separation operations involving aqueous phases. The solubility in a variety of organic solvents provides convenience for the selection of solvents in organic synthesis. During the synthesis process, according to the needs of the reaction, a suitable organic solvent can be selected to dissolve 6-chloro-3-pyridyl formonitrile to promote full contact and reaction with other reactants and improve the reaction efficiency.
In addition, the density of 6-chloro-3-pyridyl formonitrile is about 1.37 g/cm ³. Density, as one of the physical properties, has guiding value in practical operations such as material measurement and mixing. When preparing a mixed system containing 6-chloro-3-pyridyl formonitrile, the density data can help to accurately calculate the dosage of each component, ensure that the system composition is in line with expectations, and then affect the reaction results and product quality.
In summary, the physical properties of 6-chloro-3-pyridyl formonitrile, such as white to light yellow crystalline powder properties, specific melting point, solubility and density, are of great significance in many fields such as organic synthesis and chemical production, providing a key basis for related research and practice.

6-Chloro-3-pyridyl nitrile, this is an organic compound. Its chemical properties are unique, with nitrile groups and chlorine atoms, so it exhibits various reactivity.
The nitrile group is active and can be hydrolyzed to carboxylic groups. Under acidic or basic conditions, hydrolysis can occur. In acidic media, after multiple steps, pyridine-3-carboxylic acid is finally formed; under alkaline conditions, carboxylic acid is formed first, and the corresponding carboxylic acid can be obtained by acidification. This hydrolysis reaction is widely used in the preparation of carboxyl-containing pyridine derivatives.
Nitrile groups can also be reduced to amine groups. With a suitable reducing agent, such as lithium aluminum hydride (LiAlH), the nitrile group of 6-chloro-3-pyridylmethylamine can be converted into an amine group to obtain 6-chloro-3-pyridylmethylamine, which is an important organic synthesis intermediate and is crucial in the field of drug synthesis.
Furthermore, the chlorine atom has high activity and can participate in nucleophilic substitution reactions. For example, when reacting with nucleophiles such as sodium alcohol and phenol salts, the chlorine atom is replaced by the corresponding alkoxy group and phenoxy group to generate 6-alkoxy-3-pyridyl nitrile or 6-phenoxy-3-pyridyl nitrile, which is an effective path for constructing pyridyl compounds containing different substituents.
At the same time, in the molecule of 6-chloro-3-pyridyl nitrile, the electron cloud of the pyridine ring is unevenly distributed, and electrophilic substitution reactions can occur at specific locations. Due to the influence of chlorine atoms and nitrile groups, some check points of the pyridine ring are more susceptible to attack by electrophilic reagents, and pyridine derivatives with complex structures are synthesized, which adds a variety of strategies to organic synthesis chemistry.
In summary, 6-chloro-3-pyridyl formonitrile is rich in chemical properties and is a key raw material and intermediate in the field of organic synthesis. Through its diverse reactions, it can produce many valuable organic compounds, which are of great significance in many fields such as drugs and materials.

6-Chloro-3-pyridineformonitrile is in the market, and its price range is difficult to determine. The price of this product often changes for many reasons.
First, the supply and demand of the city are greatly related. If there are many people who need it, but the supply is small, the price will inevitably increase; if the supply exceeds the demand, the price will drop. Second, the cost of production is also a major factor. The price of raw materials, the simplicity of engineering technology, and the amount of energy consumption can all affect the cost of production, which in turn affects the price in the market. Third, the quality of the goods is also related to the price. Those with high quality, the price may be high; those with poor quality, the price may be low.
Looking at past transactions, the price of 6-chloro-3-pyridineformonitrile may range from a few hundred yuan per kilogram to more than a thousand yuan. However, this is only an approximate number in the past, and the price today and in the future cannot be determined. To know the exact price, you should consult chemical raw material suppliers, trading houses, or refer to recent market reports to obtain a more accurate price range.