6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

6-Chloro-3-methyl-pyridine-2-carboxylic acid methyl ester, this is an organic compound. Looking at its structure, the pyridine ring is the core, and there are chlorine atoms, methyl groups and carboxylic acid methyl ester groups attached to it.
Let's talk about its physical properties first. At room temperature, or as a solid, it also varies depending on specific environmental conditions. Its melting point, boiling point and other properties are closely related to the intermolecular force. The existence of the pyridine ring makes the molecule have a certain polarity, so its solubility also has characteristics. In organic solvents, such as ethanol and ether, there may be a certain solubility, but the solubility in water may be limited, because the hydrophobicity of the whole molecule is relatively strong. < Br >
When it comes to chemical properties, the reactivity of this compound is mostly derived from the functional groups it contains. Pyridine rings are aromatic, but the electron cloud distribution changes due to the influence of the substituents on the ring. Chlorine atoms can participate in nucleophilic substitution reactions. Under appropriate conditions, nucleophilic reagents can attack the carbon atoms attached to the chlorine atoms and replace chlorine. Methyl groups are relatively stable, but under strong oxidation conditions, they can be oxidized. The reactivity of carboxylic acid methyl ester groups is quite high, and hydrolysis can occur. Under acidic or basic conditions, ester bonds are broken to form corresponding carboxylic acids and methanol. Under alkaline conditions, hydrolysis is more complete. At the same time, the ester group can also participate in reactions such as alcoholysis and aminolysis to form new esters or amides.
In the field of organic synthesis, methyl 6-chloro-3-methyl-pyridine-2-carboxylate is often used as a key intermediate. Through the transformation of its functional groups, a variety of complex organic compounds can be constructed, which have important uses in many fields such as medicinal chemistry and materials science.

The methods for preparing methyl 6-chloro-3-methyl-pyridine-2-carboxylic acid generally include the following.
First, 6-chloro-3-methyl-pyridine-2-carboxylic acid is used as the starting material, and methanol is catalyzed by strong acids such as concentrated sulfuric acid at an appropriate temperature for esterification. In this process, acid and alcohol are mixed in a certain proportion. Concentrated sulfuric acid not only acts as a catalyst, but also absorbs the water generated by the reaction, which prompts the reaction to move in the direction of ester formation. After the reaction is completed, the product is extracted with an appropriate organic solvent, and then purified by distillation, recrystallization, etc., to obtain a relatively pure 6-chloro-3-methyl-pyridine-2-carboxylic acid methyl ester.
Second, 6-chloro-3-methyl-2-halopyridine is used to react with carbon monoxide and methanol in the presence of a catalyst. This catalyst is often a transition metal complex, such as palladium, nickel and other metals. The reaction is carried out under a certain pressure and temperature. The halogen atom in the halopyridine is replaced by a carboxyl methyl ester group to form the target product. After the reaction, the pure product is obtained through separation and purification.
Third, starting from 3-methyl-2-pyridinone, the chlorination reaction is first carried out, so that the 6-position of pyridinone is introduced into the chlorine atom, and then it is converted into the corresponding carboxylic acid, and finally prepared by esterification reaction with methanol. The chlorination reaction can use suitable chlorination reagents, such as phosphorus oxychloride, etc. The subsequent esterification reaction is similar to the first method, and the product is obtained by series of treatments.
Each method has its own advantages and disadvantages. In actual preparation, it is necessary to choose carefully according to many factors such as raw material availability, cost, reaction conditions and product purity requirements.

Methyl 6-chloro-3-methyl-pyridine-2-carboxylate has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate. In many drug development processes, it can be cleverly combined with other compounds through specific chemical reactions, carefully constructed and modified, and converted into drug molecules with specific pharmacological activities. For example, in the creation of some antibacterial drugs, it participates in the formation of core structures, which have a profound impact on the antibacterial activity and selectivity of drugs, helping drugs to accurately act on bacterial targets and achieve the effect of treating infectious diseases.
In the field of pesticide chemistry, it also plays an important role. As a starting material for the synthesis of new pesticides, highly efficient and low-toxicity pesticide varieties can be derived. For example, through the synthesis of specific pesticides, through the delicate chemical synthesis path, the new compounds it constitutes can interfere with the normal physiological activities of pests, achieve the purpose of effective pest prevention and control, and reduce the negative impact on the environment and non-target organisms, which is in line with the current trend of green and environmentally friendly pesticides.
Furthermore, in the field of organic synthetic chemistry, due to its unique molecular structure, it contains functional groups such as chlorine atoms, methyl groups and ester groups, which endow it with diverse reactivity. Chemists can flexibly use it to carry out various organic synthesis reactions according to different reaction conditions and needs, such as esterification, substitution, addition, etc., to construct complex and diverse organic compounds, providing a rich material basis for organic chemistry research and new material development. In short, methyl 6-chloro-3-methyl-pyridine-2-carboxylate plays an indispensable role in many chemical-related fields, promoting continuous progress and innovation in the pharmaceutical, pesticide and organic synthesis industries.

I look at your question, but I am inquiring about the price range of methyl 6-chloro-3-methyl-pyridine-2-carboxylate in the market. However, the price of this chemical is difficult to determine, and it is also subject to many factors.
First, the situation of supply and demand is the main reason. If the demand for this product is very high and the supply is scarce, the price will rise; conversely, if the market supply exceeds demand, the price will decline. Second, the cost of production is also crucial. The price of raw materials, the simplicity of the production process, and the amount of energy consumption will all cause cost changes, which in turn will affect the selling price. Third, the difference between brand and quality can also make the price different. Well-known brands, high-quality products, prices are often higher than ordinary ones.
In the past market, the price of this chemical fluctuated differently. In some periods, due to rising raw material prices, its cost increased, and the selling price may reach hundreds of yuan per kilogram; but when the supply is abundant and the competition is fierce, the price may drop sharply, or drop to about 100 yuan per kilogram.
However, it should be understood that the market is changing rapidly, and the current price is very different from the past. If you want to know the exact price range, you should consult chemical product suppliers, traders, or refer to the latest quotations from professional chemical product trading platforms to obtain a definite figure.

Methyl 6-chloro-3-methyl-pyridine-2-carboxylate is a kind of organic compound. Its storage conditions are quite important, which is related to the stability and quality of this substance.
According to common sense, it should be stored in a cool place. Because the temperature is too high, it is easy to cause molecular movement to intensify, or cause chemical reactions, which will damage the structure and properties of this substance. If it is exposed to hot heat and the sun, it may decompose or deteriorate. Therefore, a cool place can slow down the rate of physical and chemical changes.
and must be placed in a dry place. If this compound encounters water vapor or hydrolysis and other reactions. If you are in a humid place, water vapor lingers and fuses with it, which can cause hydrolysis of ester groups, generate corresponding acids and alcohols, and lose their original characteristics and functions.
Furthermore, it should be placed in a well-ventilated place. If it is stored in an occluded place, the volatile gas of this thing may accumulate but not disperse. On the one hand, it is dangerous for safety, or cause fires, explosions and other disasters; on the other hand, gas accumulation, or interaction with compounds, affecting its stability.
Also keep away from fire sources, heat sources and oxidants. Fire sources and heat sources can cause temperatures to rise sharply and trigger chemical reactions; oxidants have strong oxidizing properties, and contact with them can easily trigger oxidation reactions, destroy their molecular structures, and cause them to fail.
In conclusion, to properly store methyl 6-chloro-3-methyl-pyridine-2-carboxylate, choose a cool, dry, well-ventilated place away from fire, heat and oxidants, so as to maintain its quality and characteristics for future use.