6-Chloro-3-fluoro-2-(hydroxymethyl)pyridine

6-Chloro-3-fluoro-2- (hydroxymethyl) pyridine, which has a wide range of uses. In the field of pharmaceutical synthesis, it is a key intermediate. In the process of drug development, based on this, through complex organic reactions, molecular structures with specific pharmacological activities can be constructed. For example, in the creation of antibacterial drugs, by modifying and modifying their structures, new antibacterial drugs with wide antimicrobial spectrum, strong activity and small side effects can be prepared, providing a powerful "weapon" for combating bacterial infections and diseases.
In the field of pesticides, it also plays an important role. It can be used as a raw material for the synthesis of new pesticides, and chemically converted to produce pesticide products with high insecticidal, bactericidal or herbicidal properties. Such pesticides may have the characteristics of strong targeting, which can precisely act on harmful organisms and reduce the impact of non-target organisms on the environment, which is in line with the current trend of green pesticide development.
In addition, in the field of materials science, the reactions it participates in can prepare special functional materials. Or endow materials with unique properties such as good stability and optical properties, which have potential applications in the preparation of optical materials, polymer materials and many other materials, and help to improve the performance and innovative development of related materials.

The synthesis of 6-chloro-3-fluoro-2- (hydroxymethyl) pyridine involves various approaches. It is usually formed from a compound containing a pyridine ring through a substitution reaction. If a suitable pyridine derivative is used as the starting material, under specific reaction conditions, the chlorine atom and the fluorine atom occupy the 6th and 3rd positions of the pyridine ring, respectively. This substitution reaction requires the selection of a suitable halogenated reagent, the control of the reaction temperature, time and solvent, and the reaction can proceed in the desired direction.
Next, the hydroxymethyl group is introduced. The corresponding nucleophilic substitution reaction can be used to connect the hydroxymethyl group to the 2 positions of the pyridine ring with a suitable hydroxymethylation reagent under appropriate alkaline conditions. In this step, the strength of alkalinity and the activity of the reagent have important effects on the reaction yield and selectivity.
Furthermore, it may be possible to start from the perspective of constructing a pyridine ring. In a multi-step reaction, a pyridine ring skeleton containing suitable substituents is first constructed, and then modified to introduce chlorine, fluorine and hydroxymethyl groups in turn. Although this approach is a little complicated, in some cases, better reaction selectivity and yield can be obtained. In the
synthesis process, each step of the reaction requires fine control of the reaction conditions, and the intermediates and products must be identified in detail by suitable analytical means, such as chromatography, spectroscopy, etc., to confirm the structure and purity. Only in this way can the synthesis of 6-chloro-3-fluoro-2- (hydroxymethyl) pyridine be achieved efficiently and accurately.

6-Chloro-3-fluoro-2- (hydroxymethyl) pyridine is a kind of organic compound. Its physical properties are quite important and are related to many practical applications.
Looking at its appearance, under normal conditions, this substance may be in the form of white to off-white crystalline powder. This form is easy to store and use, and in many reaction systems, the powdered substance is more easily dispersed, thereby promoting the reaction.
When it comes to melting point, 6-chloro-3-fluoro-2- (hydroxymethyl) pyridine has a specific melting point range. The determination of melting point can be an important indicator of the purity of this substance. If the purity of the substance is high, the melting point range is narrow; if it contains impurities, the melting point may be offset and the range becomes wider. Accurately knowing its melting point is of great significance for the purification and quality control of the substance.
Solubility is also a key physical property. This compound has different solubility in different solvents. It may have certain solubility in common organic solvents, such as methanol and ethanol. This property makes it possible to select suitable solvents according to the needs of the reaction in organic synthesis reactions to help the reaction occur smoothly. In water, its solubility may be relatively limited, but this also affects its existence and behavior in different environments.
In addition, the density of the substance is also a physical parameter. Although its density data may not be mentioned as often as melting point and solubility, it may be necessary to consider its density in some precise chemical production processes to ensure accurate material proportions, thereby ensuring product quality and production efficiency.
In short, the physical properties of 6-chloro-3-fluoro-2- (hydroxymethyl) pyridine, such as appearance, melting point, solubility and density, are related and affect, and are of crucial significance for their applications in organic synthesis, chemical production and many other fields.

6-Chloro-3-fluoro-2- (hydroxymethyl) pyridine, this is an organic compound. Its chemical properties are unique and have a variety of characteristics.
First of all, its stability is stable at room temperature and pressure. However, in case of hot topic, it may decompose to produce toxic hydrogen chloride and hydrogen fluoride gas. This is because the chemical bond between chlorine and fluorine atoms is easily broken at high temperature, thus escaping the corresponding gas.
Then discuss its reactivity, the hydroxyl group in the molecule, so that it has a certain nucleophilicity. It can react with many electrophilic reagents, such as acyl halides, acid anhydrides, etc., and can form ester derivatives. This is because the oxygen atom of the hydroxyl group contains lone pairs of electrons, which easily attacks the electron-deficient center of the electrophilic reagent.
At the same time, the pyridine ring also endows it with unique properties. The pyridine ring is aromatic and can participate in the electrophilic substitution reaction. However, due to the electron-absorbing effect of chlorine and fluorine atoms, the electron cloud density on the pyridine ring decreases, and the electrophilic substitution reaction activity is slightly lower than that of the benzene ring. And the substitution position is also affected by the positioning effect of chlorine, fluorine, and hydroxymethyl groups. Usually, electrophilic substitution is more likely to occur at the position far away from these substituents on the pyridine ring.
And due to the presence of chlorine and fluorine atoms, the compound can participate in halogen-related reactions. For example, < Br >
This compound is widely used in the field of organic synthesis. Due to its unique chemical properties, it can be used as a key intermediate in the synthesis of various drugs, pesticides and functional materials.

I have not obtained the exact price of 6-chloro-3-fluoro-2- (hydroxymethyl) pyridine on the market. However, the price of this compound often varies due to various factors.
First, the quantity is the main factor. If the quantity is small, it is mostly purchased from chemical reagent suppliers, and the price may be higher. In order to ensure the purity and quality of the product, the reagent manufacturer has fine processing, strict packaging and quality inspection, and the cost has increased. For example, in small packages, the amount of several grams, the price per gram may reach tens of yuan to more than 100 yuan.
Second, the purity affects the price. For high purity, it is difficult to prepare, and complicated purification methods are required, and the cost rises and the price rises. High-purity products used in high-end scientific research and pharmaceutical research and development have a purity of more than 98%, and the price per gram may exceed 100 yuan or even hundreds of yuan. The industrial grade, with a slightly lower purity, is relatively cheap, but it also varies depending on the use and market supply and demand.
Third, the situation of supply and demand is also heavy. If the market demands more, but there are few producers, the price will tend to rise. On the contrary, if the supply exceeds the demand, the merchant may reduce the price to promote.
Fourth, the origin is different. For importers, due to tariffs, transportation and other fees, the price may be higher than that of domestic production. However, the imported products may be of better quality and good stability, and some users are willing to pay higher prices.
Therefore, in order to know the exact price of 6-chloro-3-fluoro-2- (hydroxymethyl) pyridine, it is necessary to carefully consider the purchase quantity, purity requirements, market supply and demand, and sources, and then inquire from various suppliers to obtain the actual price.