6-Chloro-3-cyanopyridine

6-Chloro-3-cyanopyridine is also an organic compound. It has a wide range of uses and has important applications in many fields.
Bearing the brunt, in the field of pharmaceutical synthesis, this compound is often a key intermediate. Through a series of delicate chemical reactions, it can be converted into a variety of drug molecules with specific therapeutic effects. The unique chemical structure of 6-chloro-3-cyanopyridine gives it the potential to interact with specific targets in organisms, so it provides a solid chemical basis for the development of antibacterial, anti-inflammatory, anti-tumor and other drugs.
Furthermore, in the field of pesticide creation, 6-chloro-3-cyanopyridine also plays an indispensable role. After chemical modification and optimization of synthesis processes, high-efficiency and low-toxicity pesticide products can be prepared. Such pesticides can effectively resist crop diseases and pests, ensure the growth of crops, improve crop yield and quality, and contribute greatly to the sustainable development of agriculture.
In addition, in the field of materials science, 6-chloro-3-cyanopyridine can participate in the preparation of polymer materials with special properties. It can be used as a functional monomer to polymerize with other monomers to form polymers with unique electrical, optical or mechanical properties. For example, in the synthesis of organic optoelectronic materials, the use of their structural characteristics can optimize the charge transport and luminescence properties of materials, contributing to the development of new display technologies and optoelectronic devices.
6-chloro-3-cyanopyridine, with its unique chemical properties, plays a crucial role in many key fields such as medicine, pesticides and materials science, and promotes the continuous progress and innovation of related industries.

6-Chloro-3-cyanopyridine is one of the organic compounds. It has specific physical properties and is very important in the field of chemistry.
Looking at its properties, under normal circumstances, 6-chloro-3-cyanopyridine is mostly white to light yellow crystalline powder. This appearance feature is easy to identify and operate.
The melting point is about 104-107 ° C. The characteristics of the melting point are quite useful in the identification and purity judgment of the substance. If the melting point deviates from this range, it may be inferred that the purity of the substance is poor, and impurities are mixed, causing the melting point to change.
Solubility is also an important property. 6-Chloro-3-cyanopyridine has a certain solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. In dichloromethane, due to the adaptation of the forces between the two molecules, it can be well miscible. However, in water, its solubility is very small. This difference in solubility must be carefully considered when separating, purifying and constructing the reaction system of compounds.
Furthermore, its density also has characteristics. Although the exact value or varies depending on the measurement conditions, it is generally within a certain range. Density is related to the distribution of substances in the mixed system, and is of guiding significance for material ratio and reaction vessel selection in chemical production and experimental operations.
In addition, the vapor pressure of 6-chloro-3-cyanopyridine is very low. This means that under normal conditions, its degree of volatilization is limited. This ensures the stability of the substance during storage and transportation, reducing losses due to volatilization or safety risks. In conclusion, the physical properties of 6-chloro-3-cyanopyridine, such as its appearance, melting point, solubility, density, and vapor pressure, are key factors in its research, production, and application, which help researchers and producers better control the behavior and properties of this compound.

The synthesis method of 6-chloro-3-cyanopyridine has been explored by many parties throughout the ages, and each has its own method.
First, 6-chloro-3-methylpyridine is used as the starting material. In a suitable reaction vessel, prepare a strong oxidant, such as potassium permanganate. Add 6-chloro-3-methylpyridine slowly, and under suitable temperature and stirring conditions, oxidize the methyl group to a carboxyl group to obtain 6-chloro-3-pyridinecarboxylic acid. Then, the product is co-heated with dichlorosulfoxide to convert the carboxyl group into an acyl chloride, which is 6-chloro-3-pyridyl formyl chloride. Finally, cyanide reagents such as sodium cyanide are added, and 6-chloro-3-cyanopyridine can be obtained through nucleophilic substitution.
Second, 3-cyanopyridine is used as the starting material. It is placed in a halogenation reaction system, and the halogenation reaction is carried out in the presence of chlorine gas or a chlorine-containing halogenation reagent, such as N-chlorosuccinimide (NCS), in the presence of light or an initiator. Due to the difference in electron cloud density at different positions on the pyridine ring, chlorine atoms can be introduced at the 6 position to prepare 6-chloro-3-cyanopyridine.
Third, palladium-catalyzed coupling reaction is used. Select suitable halogenated pyridine derivatives, such as 3-cyano-6-iodopyridine, and chlorine sources, such as zinc chloride or other organochlorine reagents, under the catalysis of palladium catalysts, such as tetra (triphenylphosphine) palladium, add an appropriate amount of bases, such as potassium carbonate, etc., in a suitable organic solvent, through coupling reaction to generate 6-chloro-3-cyanopyridine. This method has relatively mild conditions and high selectivity.
All synthetic methods have their own advantages and disadvantages, and need to be carefully selected according to actual needs and conditions.

6-Chloro-3-cyanopyridine is also an important substance in chemistry. During storage and transportation, pay attention to all things.
The first priority is safety. This substance is dangerous to a certain extent, or irritating, harmful to human health, or flammable and explosive. Therefore, the storage must be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and avoid mixing with strong oxidants, acids, alkalis and other substances to prevent chemical reactions and cause danger. When shipping, it must also strictly abide by relevant regulations, properly protect it, and ensure its safety on the way.
The second time is packaging. Appropriate packaging materials must be used and sealed tightly to prevent leakage. On the packaging, there should be a clear and accurate logo, indicating its name, sex, risk, etc., so that those who see it know it, so as to policy safety.
Furthermore, observe its status. Between storage and transportation, always observe whether it has leakage or deterioration. If you see package damage or odor, etc., deal with it as soon as possible, and do not let it go.
You must also remember the temperature and humidity of the storage. Improper temperature, humidity, or change the physical properties. According to its nature, control the temperature and humidity of the storage place to ensure the stability of its quality.
At the time of transportation, choose the appropriate transportation equipment and prepare the necessary emergency materials. If an accident occurs, it can be rescued and treated immediately to minimize the damage. All of these should be taken into account when storing and transporting 6-chloro-3-cyanopyridine.

The market price range of 6-chloro-3-cyanopyridine is difficult to determine. This compound has a wide range of uses in the chemical industry, and its price fluctuates due to many factors.
Looking at the past market, its price is influenced by raw material costs, supply and demand trends, and production process difficulties. If raw materials are abundant and the production process is mature, the price may stabilize and be slightly lower; however, raw materials are scarce and the process is complex, and the price will rise.
In terms of past transactions, when purchasing in bulk, if the quality is average, the price per kilogram may be hundreds of yuan; if the quality is high, coupled with strong market demand, the price per kilogram may exceed 1,000 yuan. But this is only a rough guess, and the actual price varies from time to time. And the quotations of different regions and different suppliers are also different. Where the coastal chemical industry is developed, the price may be relatively low due to low transportation costs, industrial agglomeration, etc.; where the inland is remote, the price may be slightly higher. In order to know the accurate market price, when consulting local suppliers in detail, you can get the current appropriate market price range.