6 Chloro 3 Aminopyridine 2 Carboxamide
pyridine pyrrole pyrazine piperidine piperazine

6-Chloro-3-aminopyridine-2-carboxamide

    Specifications

    HS Code

    994684

    Chemical Formula C6H6ClN3O
    Molar Mass 169.585 g/mol
    Appearance Solid (usually white or off - white)
    Physical State At Room Temperature Solid
    Melting Point Data - specific value needed (usually in a certain temperature range, e.g., 150 - 155°C)
    Boiling Point Data - specific value needed (estimated based on similar compounds)
    Solubility In Water Limited solubility, specific value needed
    Solubility In Organic Solvents Soluble in some organic solvents like ethanol, acetone, specific solubility values needed
    Pka Value Data - specific value needed (related to its acidic or basic nature in solution)
    Density Data - specific value needed (usually in g/cm³)

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    General Information
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    Frequently Asked Questions

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    What are the chemical properties of 6-Chloro-3-aminopyridine-2-carboxamide?
    6-Chloro-3-aminopyridine-2-formamide is an organic compound with unique chemical properties. It contains chlorine atoms, amino groups and formamide groups, giving this compound a variety of reactivity.
    Let's talk about the physical properties first. Under normal conditions, 6-chloro-3-aminopyridine-2-formamide may be a solid, due to the existence of various forces between molecules, such as hydrogen bonds, van der Waals forces, etc., which promote the close arrangement of molecules. Its melting point and boiling point are affected by molecular structure and interactions, or relatively high due to strong intermolecular forces. As for solubility, due to the presence of polar groups, it may have a certain solubility in polar solvents such as alcohols and water, but the presence of chlorine atoms may limit its dissolution in non-polar solvents.
    Chemical properties, the presence of amino groups makes this compound alkaline and can react with acids to form salts. Amino groups are also nucleophilic groups and can participate in nucleophilic substitution reactions, such as reacting with halogenated hydrocarbons to form new nitrogen-containing compounds. Chlorine atoms are active and can undergo nucleophilic substitution, which can be replaced by other nucleophilic reagents to form different derivatives. Formamide groups can also participate in reactions, such as hydrolysis reactions, under the catalysis of acids or bases, to generate corresponding carboxylic acids and ammonia or amines.
    The reactivity of 6-chloro-3-aminopyridine-2-formamide is derived from the characteristics and interaction of functional groups. These chemical properties make it widely used in the field of organic synthesis and can be used as a key intermediate in the preparation of various drugs, pesticides and functional materials.
    What is 6-Chloro-3-aminopyridine-2-carboxamide synthesis method?
    The synthesis method of 6-chloro-3-aminopyridine-2-formamide, although the ancient book "Tiangongkai" does not contain this substance, it can be compared to the chemical synthesis described in the book.
    To synthesize this substance, pyridine can be used as the starting material first. Pyridine is aromatic and has a specific electron cloud distribution on the ring. Halogenation reaction can be used to replace chlorine atoms at the 6th position of the pyridine ring. Commonly used halogenating agents such as chlorine gas, sulfoxide chloride, etc. Under suitable conditions, chlorine gas can react with pyridine under light or catalyst action, and chlorine atoms can selectively replace 6 hydrogen atoms to obtain 6-chloropyridine.
    Then, the amino group is introduced at the 3rd position. This step can be achieved by nucleophilic substitution reaction. With suitable amination reagents, such as ammonia gas and suitable catalysts, under high temperature and high pressure conditions, the amino group in the ammonia gas can replace the chlorine atom at the 3rd position of 6-chloropyridine to obtain 6-chloro-3-aminopyridine.
    Finally, the formamide group is introduced at the 2nd position. It can be achieved by first reacting 6-chloro-3-aminopyridine with suitable acylating reagents, such as formyl chloride or ethyl formate. Taking formyl chloride as an example, in the presence of an alkali catalyst such as triethylamine, the carbonyl carbon of formyl chloride is electrophilic and interacts with the electron cloud of 6-chloro-3-aminopyridine 2 position to undergo nucleophilic addition-elimination reaction to form 6-chloro-3-aminopyridine-2-formamide. After each step of the reaction, it needs to be separated and purified by methods such as distillation, recrystallization, column chromatography, etc., to remove impurities and obtain a pure product.
    6-Chloro-3-aminopyridine-2-carboxamide in what areas
    6-Chloro-3-aminopyridine-2-formamide, an organic compound, is useful in many fields.
    In the field of medicine, it can be used as a key intermediate for the synthesis of biologically active drug molecules. For example, its structure can be modified by specific chemical reactions to create compounds with therapeutic potential for specific diseases. In the development of some antibacterial and anti-inflammatory drugs, 6-chloro-3-aminopyridine-2-formamide may be used as the starting material to create drugs that can effectively inhibit the growth of pathogens or regulate the body's immune response through multi-step reactions.
    In the field of pesticides, it also has its own influence. It can be chemically converted to create new pesticides. For example, an insecticide with high selective toxicity to pests but little impact on the environment and non-target organisms is designed, or a fungicide that can effectively inhibit the growth of plant pathogens. The unique structure of this compound gives it the possibility to interact with specific targets in organisms, thus achieving the purpose of precision killing pests.
    In the field of materials science, 6-chloro-3-aminopyridine-2-formamide also has potential applications. It can be used as a basic unit for the construction of functional materials and participate in the synthesis of polymers with special photoelectric properties. For example, by copolymerizing with specific monomers, materials that can be used in optoelectronic devices such as organic Light Emitting Diodes (OLEDs) or solar cells can be prepared. Due to their structural properties, they can optimize the charge transport performance and luminous efficiency of materials and improve the overall performance of optoelectronic devices.
    In summary, 6-chloro-3-aminopyridine-2-formamide has shown important application value in the fields of medicine, pesticides and materials science due to its unique chemical structure, providing a key material foundation for innovation and development in various fields.
    What is the market outlook for 6-Chloro-3-aminopyridine-2-carboxamide?
    6-Chloro-3-aminopyridine-2-formamide, this product has considerable market prospects and challenges.
    Looking at its use, it is a key intermediate in the field of medicine and chemical industry. It can produce antibacterial, anti-inflammatory and other drugs. With the vigorous development of the pharmaceutical industry, the demand for it may grow. And the research and development of new drugs continues to advance. If innovative drugs can be developed based on this, the market demand will be greatly boosted.
    However, the market competition is also very fierce. Many chemical companies are involved in the production of such intermediates, which has caused great pressure on the supply side. To stand out, companies must have strong technical strength and cost control capabilities. Furthermore, environmental regulations are becoming increasingly stringent, and high standards of environmental protection requirements need to be met in the production process, which poses challenges to the production process and cost of enterprises.
    Raw material price fluctuations also affect their market prospects. The supply of raw materials may be unstable due to various factors, resulting in difficult cost control. If raw material prices rise sharply, product prices may also fluctuate, affecting market demand and corporate profits.
    Overall, although the market prospect of 6-chloro-3-aminopyridine-2-formamide has room for growth due to the demand of the pharmaceutical industry, factors such as competition, environmental protection and raw material prices make its development path uncertain. Enterprises need to respond cautiously in order to gain a place in the market.
    Is the production process of 6-Chloro-3-aminopyridine-2-carboxamide complicated?
    The production process of 6-chloro-3-aminopyridine-2-formamide is not simple. This compound has a wide range of uses and is crucial in the field of pharmaceutical research and development. However, its preparation requires fine planning and operation.
    Bear the brunt, and the selection of raw materials is extremely critical. To obtain a pure and high-quality product, the selected raw materials must be of high purity and less impurities. This involves the procurement and screening of raw materials. It is necessary to carefully consider the qualifications of suppliers, raw material quality inspection reports, etc., in order to ensure the quality of the starting materials.
    Furthermore, the reaction steps are complex and diverse. Common synthesis paths or involve multiple chemical reactions, such as halogenation, amination, amidation, etc. The reaction conditions at each step need to be precisely controlled. Factors such as temperature, pressure, reaction time, and the proportion of reactants can affect the yield and purity of the product if there is a slight difference. Taking the halogenation reaction as an example, if the temperature is too high, it may cause side reactions to occur, resulting in unnecessary impurities; if the temperature is too low, the reaction rate will be slow and take too long.
    In addition, the choice of reaction solvent cannot be ignored. Different solvents have a significant impact on the reaction rate and selectivity. A suitable solvent can not only promote the dissolution of the reactants and make the reaction proceed uniformly, but also assist in the separation and purification of the products.
    The post-processing stage is also challenging. After the reaction, the product is often mixed with unreacted raw materials, by-products and solvents. It is necessary to use separation and purification methods such as extraction, distillation, and recrystallization to obtain high-purity 6-chloro-3-aminopyridine-2-formamide. This process is cumbersome and requires strict follow of operating procedures to achieve the desired effect.
    In summary, the production process of 6-chloro-3-aminopyridine-2-formamide is complicated, and producers need to be careful in all aspects to ensure product quality and production efficiency.