6-Chloro-3,4-pyridinedicarboxylic acid

6-Chloro-3,4-pyridinedicarboxylic acid, which is acidic because it contains carboxyl groups, can neutralize with bases such as sodium hydroxide to form corresponding carboxylic salts and water. Its chlorine atom is active and can undergo nucleophilic substitution reactions. For example, with alcohols catalyzed by bases, chlorine atoms can be replaced by alkoxy groups to obtain corresponding ether products.
The pyridine ring of this compound is aromatic and can participate in electrophilic substitution reactions, but due to the electron-withdrawing effect of chlorine atoms and carboxyl groups, the reactivity is slightly lower than that of benzene rings. In the case of electrophilic substitution, the carboxyl group and the chlorine atom will affect the position of the substituent entering the pyridine ring. The carboxyl group is the meta-site locator, and the chlorine atom is the o-site locator and the para-site locator. Under the combined influence, the electrophilic substitution reaction mainly occurs at the specific position of the pyridine ring.
In addition, the carboxyl group in the molecule of 6-chloro-3,4-pyridinedicarboxylic acid can undergo esterification reaction, and the ester compound is formed under the condition of acid catalysis and co-heating with alcohol. It may also participate in other organic reactions such as condensation reactions, and has potential application value in the field of organic synthesis. It can

6-Chloro-3,4-pyridinedicarboxylic acid, an important organic compound, is widely used in many fields.
First, in the field of medicinal chemistry, its use is quite critical. Due to the particularity of the structure of pyridinedicarboxylic acid, 6-chloro-3,4-pyridinedicarboxylic acid can be used as a key intermediate for the synthesis of a variety of drugs. With its chemical properties, it can participate in complex organic reactions and construct molecular structures with specific pharmacological activities. For example, it can be used to synthesize some anti-tumor drugs. By precisely modifying its structure, it can target tumor cells, inhibit the growth and spread of tumor cells, and contribute an important force to conquering cancer problems; or it can be used to synthesize antibacterial drugs. With its unique chemical activity, it interferes with the metabolic process of bacteria, achieves antibacterial effect, and provides a powerful weapon for human beings to resist bacterial infection.
Second, in the field of materials science, 6-chloro-3,4-pyridinedicarboxylic acid also plays an important role. It can take advantage of its coordination reaction with metal ions to prepare metal-organic framework materials (MOFs). Such materials have excellent properties such as high specific surface area and regular pore structure, and show extraordinary potential in gas adsorption and separation. For example, it can efficiently adsorb specific gas molecules and achieve precise separation of mixed gases, which has broad application prospects in industrial gas purification and environmental protection. At the same time, in the field of catalysis, the material can also play a catalytic role in specific chemical reactions by virtue of its unique structure and activity check point, improve reaction efficiency and selectivity, and promote the development of the chemical industry.
Third, in the field of organic synthesis chemistry, 6-chloro-3,4-pyridine dicarboxylic acid, as an important starting material and intermediate, participates in many organic synthesis reactions. Its chlorine atom and carboxyl group can undergo various substitution, condensation and other reactions, providing various possibilities for the construction of complex organic molecular structures. By ingeniously designing reaction paths, organic compounds with special functions and structures can be synthesized to meet the needs of different fields for special organic materials, such as new optoelectronic materials, high-performance polymers, etc., thus promoting organic synthesis chemistry to new heights.

The synthesis method of 6-chloro-3,4-pyridinedicarboxylic acid is covered by various paths in the ancient books. One method is to use pyridine as the initial material, and through halogenation, the chlorine atom is selected to be attached to the 6 position of the pyridine ring. This halogenation method may use chlorine gas, chlorination agent, etc., in the environment of temperature and pressure and catalyst, so that the reaction can proceed in an orderly manner. Then, the 3 and 4 alkyl groups of the pyridine ring or other oxidizable groups are converted into carboxylic groups by suitable oxidation methods. This oxidation process, either with strong oxidants such as potassium permanganate, or with a specific catalytic oxidation system, requires precise temperature control and time control to obtain a pure product. < Br >
Another way to synthesize is to use pyridine derivatives containing specific substituents as starting materials. If the starting material already has some of the desired substituents, it only needs to be converted and modified by functional groups. For example, there are pyridine derivatives, which have groups that can be converted into carboxyl groups at the 3rd and 4th positions and groups that can be converted into chlorine atoms at the 6th position. After a series of nucleophilic substitution, oxidation and other reactions, the groups can be precisely converted, and the purpose of synthesizing 6-chloro-3,4-pyridine dicarboxylic acid can also be achieved.
Furthermore, organometallic reagents can be used to participate in the reaction. First, the metal reagent interacts with a suitable pyridine substrate, introduces the activity check point at a specific position of the pyridine ring, and then reacts with the chlorine-containing reagent and the carboxylating reagent in sequence. This process requires detailed consideration of the activity, reaction sequence and reaction conditions of the metal reagent, so that each step of the reaction is smooth to obtain the target product. Each method has its own advantages and disadvantages, and the appropriate synthesis path needs to be carefully selected according to the actual raw material availability, cost, yield and purity requirements.

What you are inquiring about is the price range of 6-chloro-3,4-pyridyldicarboxylic acid in the market. However, the price in the market often changes with time, and it also varies with supply and demand, quality, source and other factors.
In the past, the price of chemical raw materials was often determined by the distance of the place of origin and the difficulty of making them. If the product is produced nearby and the production method is simple, its price may be inexpensive; if it is shipped from afar and the production method is complicated, the price will be high. < Br >
Although there is no exact price to tell you today, it is common sense that in the chemical reagent market, if such compounds are of ordinary purity, the price per gram may be between a few and tens of yuan. If they are of high purity and are used for special purposes, the price may reach more than 100 yuan per gram.
Due to market fluctuations, or due to scarcity of raw materials, or due to process improvement, the price will also rise and fall. To know the exact price, you should consult the chemical raw material supplier, or check in detail on the chemical product trading platform, to obtain the current accurate price range.

6-Chloro-3,4-pyridinedicarboxylic acid is one of the chemical substances. The conditions for its storage are quite important.
This substance should be placed in a cool and dry place. In a cool place, there is no danger of hot sun and cool sun, and it can avoid the change of its properties due to high temperature. In a dry place, there is no water vapor intrusion to prevent it from getting damp and causing qualitative change.
It should also be noted that it should be placed in a well-ventilated place. If the ventilation is good, the air circulation can avoid the accumulation of harmful gases caused by a closed environment, which will affect the stability of this substance.
And when stored separately from oxidizing substances, alkaline substances, etc. Oxidative substances are active and easily react with 6-chloro-3,4-pyridinedicarboxylic acid, causing it to deteriorate; alkaline substances, when encountered with them, may also cause chemical changes and damage their quality.
Store away from fire and heat sources. Fire and heat sources may cause their temperature to rise sharply, triggering the risk of combustion or even explosion.
In terms of packaging, it is necessary to ensure that it is tight. Tight packaging can prevent external air, water vapor, etc. from contacting with its contents to ensure long-term and stable quality.
Check regularly on a daily basis to see if the packaging is damaged and whether the substance has abnormal changes. If the package is damaged, dispose of it as soon as possible to prevent the material from spilling and endangering the surroundings.
Storage of 6-chloro-3,4-pyridinedicarboxylic acid must follow the above conditions to ensure its safety and quality for future needs.