6-chloro-2-(chloromethyl)H-imidazo[1,2-a]pyridine

6-Chloro-2- (chloromethyl) -H-imidazolo [1,2-a] pyridine, this is an organic compound. It has a wide range of uses and is of great significance in the field of medicinal chemistry.
In the process of drug development, it is often used as a key intermediate. By chemical synthesis, it can be converted into compounds with specific biological activities, which are expected to become new drugs for the treatment of diseases. For example, its chemical structure can be modified to enhance its affinity for specific targets and achieve the purpose of efficient treatment of diseases.
In the field of materials science, it also has its uses. Due to specific chemical structures, or endowing materials with unique properties. Or it can be combined with other materials to obtain new materials with special electrical, optical or mechanical properties, which can be used in electronic devices, optical materials and other fields.
In addition, in organic synthetic chemistry, as an important building block, it participates in the construction of various complex organic molecules. With its unique reactivity, it reacts with various reagents to achieve efficient synthesis of complex organic compounds and promote the progress of organic synthetic chemistry.
In short, 6-chloro-2- (chloromethyl) -H-imidazolo [1,2-a] pyridine with its unique chemical structure has shown important value in many fields such as medicine, materials and organic synthesis, providing key support and possibility for the development of various fields.

The synthesis method of 6-chloro-2- (chloromethyl) -H-imidazolo [1,2-a] pyridine, although the book "Tiangong Kaiwu" does not contain the specific synthesis method of this compound, it can follow the ancient chemical process idea and use the method of similar synthesis to deduce it.
To form this compound, you can start from a simple raw material containing the structure of pyridine and imidazole. First, find the compound with the structure of pyridine, and introduce the chlorine atom at the specific position of pyridine at a suitable temperature and reaction environment to obtain the chloropyridine derivative. In this step, attention should be paid to the dosage of halogenating agent, reaction time and temperature control to prevent over-halogenation or formation of by-products.
Second, for the construction of imidazole structure, the corresponding nitrogen-containing raw materials, such as ethylenediamine or its derivatives, and carbonyl-containing compounds, under the catalysis of acid or base, can be condensed to form imidazole rings. In the process, the type of catalyst, the amount of catalyst and the acidity and alkalinity of the reaction system have a great influence on the reaction process and product purity.
Third, the products obtained in the first two steps are combined, or through nucleophilic substitution reaction, the chloropyridine-containing derivatives are reacted with the imidazole-containing ring intermediates under the action of suitable solvents and bases, and chloromethyl is introduced into In this step, the polarity of the solvent, the strength and dosage of the base are all related to the reaction efficiency and product yield.
After the reaction is completed, the product or impurities need to be separated and purified by distillation, recrystallization or column chromatography according to its physical and chemical properties to obtain pure 6-chloro-2- (chloromethyl) -H-imidazolo [1,2-a] pyridine. Although the ancients did not have this compound, today we can explore the best way to synthesize it according to chemical principles and technology and the wisdom of ancient technology.

6-Chloro-2- (chloromethyl) -H-imidazolo [1,2-a] pyridine, which is an organic compound. Looking at its physical and chemical properties, it is mostly solid at room temperature, but it also depends on its specific crystal form and purity. Determination of its melting point is crucial for the identification and purification of this compound. Under different conditions, the melting point may vary due to factors such as impurities and crystal form transformation.
When it comes to solubility, it exhibits a certain solubility in organic solvents, such as common ethanol, dichloromethane, acetone, etc. This property is convenient for its operation in organic synthesis reactions, which can make the reactants better contact each other and improve the reaction efficiency. However, in water, its solubility is low. Due to the limited proportion of polar groups in the molecular structure of the compound, the force between it and water molecules is weak.
Its chemical properties are active, and the presence of chlorine atoms in the molecular structure endows it with many reactivity. The chlorine atoms on chloromethyl groups are prone to nucleophilic substitution reactions, which can provide an opportunity for the introduction of other functional groups. The conjugate structure of the imidazolopyridine ring makes it have a certain electron cloud density distribution characteristics, and under specific conditions, it can participate in electrophilic substitution reactions. And because the compound contains nitrogen heterocycles, it has a certain alkalinity and can react with acids to form salts. This property may be used for its separation and purification, and it is also of great significance for its application in the field of medicinal chemistry. Due to the fact that compounds after salt formation often change their solubility and stability, making them more suitable for preparation requirements.

I have not heard of the price of "6 - chloro - 2 - (chloromethyl) H - imidazo [1,2 - a] pyridine" in the market. However, if you want to know the price of this product, you can explore it from many ways.
First, visit all kinds of chemical reagents. In today's world, there are many chemical reagent companies, such as Sinopharm Group Chemical Reagent Co., Ltd., which sell all kinds of chemical reagents, or have this thing. You can send it to its store and ask the shopkeeper; or call its phone to ask the price in detail. You can also visit its official website to check the price of the product to know its approximate.
Second, look for online trading platforms. Nowadays, e-commerce is prosperous, and there are many chemical product trading platforms, such as Gade Chemical Network. You can log in to these platforms and ask for the keyword "6-chloro-2 - (chloromethyl) H-imidazo [1,2 - a] pyridine". The platform or list of multiple suppliers and their quotations can be compared to know the market.
Third, ask the manufacturer. If you can find the manufacturer of this product, ask the factory directly for its quotation, and you can get the first-hand price. You can use the chemical industry directory, search engine, etc. to find the contact information of the manufacturer, and inquire by email or phone.
Fourth, refer to the industry exhibition. The chemical industry often holds exhibitions. At such exhibitions, you can meet suppliers and manufacturers, talk with each other, ask about the price of their products, and observe the quality of their products to get more product information.
However, the price may change for many reasons, such as the amount, the quality, the supply and demand of the market, and the difference in time. Therefore, if you want to get a definite price, the actual inquiry shall prevail.

6-Chloro-2- (chloromethyl) -H-imidazolo [1,2-a] pyridine is an organic compound that is widely used in chemical, pharmaceutical and other fields. However, when using this substance, there are many safety issues, so be sure to pay attention.
First, protective measures are the key. This compound has certain toxicity and irritation, and protective equipment is essential when in contact. In experiments or production occasions, protective clothing is required, which can effectively block the compound from coming into contact with the body and avoid skin damage. In addition, protective gloves are also indispensable. It is advisable to choose chemical-resistant materials to ensure hand safety. Facial protection should not be ignored. Wear protective glasses or masks to prevent compounds from splashing into the eyes and causing serious damage to the eyes.
Second, the operating environment should also be paid attention to. It should be operated in a well-ventilated place, and the best choice is a place with a fume hood. The fume hood can drain volatile compounds in time, reduce the concentration in the air, and reduce the risk of inhalation. If the operating space is poorly ventilated, compounds will accumulate, which can easily cause respiratory problems, and in severe cases may be life-threatening.
Third, storage should also be paid attention to. It should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Because of its flammability, in case of open flames or hot topics, it may cause combustion or even explosion. Contact with oxidants, or cause violent chemical reactions, resulting in dangerous accidents. The storage container should also be well sealed to prevent leakage.
Fourth, emergency treatment should not be ignored. In the event of a leak, quickly evacuate unrelated personnel and isolate the scene. In the event of a small leak, it can be absorbed by inert materials such as sand and vermiculite and collected in an airtight container. In the event of a large leak, an embankment should be built or a pit should be dug for containment, covered with foam to reduce volatilization. If it accidentally touches the skin, the contaminated clothing should be removed immediately and rinsed with a large amount of flowing water. If it splashes into the eyes, the eyelids should be lifted immediately, rinsed with flowing water or normal saline, and seek medical attention in time.
In conclusion, when using 6-chloro-2- (chloromethyl) -H-imidazolo [1,2-a] pyridine, the above safety precautions must be kept in mind and must not be ignored, so as to ensure the safety of personnel and the environment.