6 Chloro 2 3 Diaminopyridine
pyridine pyrrole pyrazine piperidine piperazine

6-Chloro-2,3-diaminopyridine

    Specifications

    HS Code

    975323

    Chemical Formula C5H6ClN3
    Molar Mass 143.57 g/mol
    Appearance Solid
    Color Typically white to off - white
    Solubility In Water Moderate solubility
    Melting Point 165 - 169 °C
    Boiling Point Decomposes before boiling
    Odor Weak, characteristic odor
    Density Approx. 1.45 g/cm³
    Pka Value Relevant pKa values for amino groups exist
    Stability Stable under normal conditions, but may react with strong oxidizing agents

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    Frequently Asked Questions

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    What are the chemical properties of 6-Chloro-2,3-diaminopyridine?
    6-Chloro-2,3-diaminopyridine, this is an organic compound. Its chemical properties are unique and have a variety of characteristics.
    First of all, there are chlorine atoms and amino groups in its structure, and the chlorine atoms have certain electronegativity, which makes the compound have a certain polarity. The amino group brings it basic properties. This compound plays an important role in the field of organic synthesis. Due to the presence of amino groups, it can participate in many nucleophilic reactions.
    For example, it can react with acyl chloride to form an amide bond. In this reaction process, the nitrogen atom of the amino group attacks the carbonyl carbon of the acyl chloride with its lone pair of electrons, and the chlorine atom leaves to form a new amide compound. The reaction conditions are usually mild and can be carried out under the catalysis of a base in a suitable solvent.
    Furthermore, the compound can participate in the cyclization reaction. Under suitable reagents and conditions, its amino groups can react with other check points on the pyridine ring to form more complex cyclic structures. This process involves the rearrangement of electron clouds and the formation of chemical bond breaks, which can create a variety of novel cyclic compounds.
    In addition, the chlorine atom of 6-chloro-2,3-diaminopyridine can be replaced by nucleophilic reagents. Nucleophilic reagents, with their electron-rich properties, attack the carbon atoms attached to chlorine, and the chlorine leaves to achieve the conversion of functional groups. This substitution reaction provides the possibility for the synthesis of diverse derivatives.
    In conclusion, 6-chloro-2,3-diaminopyridine is widely used in the field of organic synthetic chemistry due to its unique chemical structure, and complex organic molecular structures can be constructed through various reaction pathways.
    What are the main uses of 6-Chloro-2,3-diaminopyridine?
    6-Chloro-2,3-diaminopyridine has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Geinpyridine has a stable structure and unique electronic properties. 6-chloro-2,3-diaminopyridine can introduce various functional groups through specific reactions, and then construct complex drug molecules. For example, when synthesizing antibacterial drugs, using this as the starting material, compounds with specific antibacterial activities can be obtained through multi-step reactions, which can effectively inhibit the growth and reproduction of some bacteria, which is of great significance for the development of anti-infection drugs.
    It is also used in materials science. Because amino groups and chlorine atoms can participate in many polymerization reactions, new functional materials can be prepared. For example, when preparing optoelectronic materials, introducing them into the polymer structure can adjust the electronic transport properties and optical properties of the materials, so that the materials show potential application value in the fields of Light Emitting Diode, solar cells and so on.
    In the field of organic synthetic chemistry, it is an important building block for the construction of complex pyridine derivatives. Chemists can achieve various pyridine ring modifications by selective reaction of chlorine atoms and amino groups to synthesize organic compounds with novel structures, which has a positive impact on the development of organic synthesis methodologies and the creation of new compounds.
    What are the synthesis methods of 6-Chloro-2,3-diaminopyridine?
    The synthesis of 6-chloro-2,3-diaminopyridine has many different paths. First, it can be started from 6-chloro-2-nitropyridine. First, with a suitable reducing agent, such as hydrogen and a suitable catalyst (such as palladium carbon), under suitable reaction conditions, the nitro group is reduced to an amino group to obtain 6-chloro-2-aminopyridine. Then, through a specific nitrifying agent, in a suitable reaction system, the nitro group is introduced at the 3 position of the pyridine ring, and then the newly introduced nitro group is reduced again to obtain 6-chloro-2,3-diaminopyridine.
    Second, 2,3-diaminopyridine can also be used as the starting material. First, the synthesis of 6-chloro-2,3-diaminopyridine can be achieved by introducing chlorine atoms at the 6 position of the pyridine ring through chlorination reagents, such as chlorine gas or chlorine-containing compounds, in a suitable reaction environment.
    Furthermore, 3-amino-6-chloropyridine-2-formonitrile is used as the starting material. After hydrolysis, the nitrile group is converted into a carboxyl group, and then the carboxyl group is converted into an amino group. 6-chloro-2,3-diaminopyridine can also be synthesized. It should be noted that each synthesis path has its own unique reaction conditions, such as temperature, pressure, reaction time, and the proportion of reactants, which need to be carefully adjusted to achieve higher yield and purity. Each path has its own advantages and disadvantages. In actual synthesis, the appropriate method should be carefully selected according to specific needs and conditions.
    What are the precautions for 6-Chloro-2,3-diaminopyridine in storage and transportation?
    6-Chloro-2,3-diaminopyridine, when storing and transporting, it is necessary to pay attention to many matters.
    The chemical properties of this substance are relatively active. When storing, the first environment is dry. The cover must be stored in a dry and well-ventilated place, away from water sources and moisture, to prevent moisture from dissolving.
    Temperature is also key. It should be avoided from high temperature and stored in a cool place. High temperature can easily cause chemical reactions such as decomposition of the substance, which will damage its quality. Generally speaking, the storage temperature should be controlled within a specific range, depending on its physical and chemical properties, usually not exceeding normal temperature.
    Furthermore, the storage place must be kept away from fire sources and oxidants. 6-Chloro-2,3-diaminopyridine is flammable, and there is a risk of combustion and explosion in case of open flames and hot topics; contact with oxidants can also easily cause violent reactions, so the two must be stored separately.
    As for transportation, packaging must be strict. Suitable packaging materials should be used to ensure good sealing to prevent leakage during transportation. When loading and unloading, be careful, handle lightly, and do not throw or collide to avoid leakage caused by package damage.
    Transportation tools should also be careful. They should be clean, dry and free of other chemical residues to avoid mixing with incompatible substances. Transportation routes should also be planned carefully, away from densely populated areas and important facilities to reduce transportation risks and ensure the safety of people and the environment. In this way, 6-chloro-2,3-diaminopyridine must be properly stored and transported.
    What is the market outlook for 6-Chloro-2,3-diaminopyridine?
    6-Chloro-2,3-diaminopyridine, an important intermediate in organic synthesis, has significant applications in many fields such as medicine, pesticides and materials. Looking at its market prospects, it is indeed a bright one.
    From the perspective of the pharmaceutical field, with the vigorous rise of innovative drug research and development, the synthesis of many new drugs requires this intermediate. For example, the preparation of some anti-cancer drugs and anti-infective drugs, 6-chloro-2,3-diaminopyridine is indispensable. As cancer and infectious diseases have always been a major threat to human health, the demand for related drugs continues to rise, and the position of this intermediate in the pharmaceutical synthesis process is becoming more and more critical, and the market demand is also rising.
    In the field of pesticides, with the increasing emphasis on the quality, safety and environmental protection of agricultural products, the research and development of high-efficiency, low-toxicity and environmentally friendly pesticides has become the general trend. 6-Chloro-2,3-diaminopyridine can be used as a key raw material for the synthesis of such new pesticides, contributing to the upgrading and transformation of the pesticide industry. Therefore, with the development of the pesticide industry, the demand for this intermediate will also rise steadily.
    Furthermore, in the field of materials science, with the rapid development of high-tech industries, the demand for special performance materials continues to emerge. Some of the functional materials involved in the synthesis of 6-chloro-2,3-diaminopyridine exhibit unique properties in electronics, optics and other fields, and have broad application prospects. With the continuous expansion of related industries, the demand for this intermediate will also gradually increase.
    From the supply side, many chemical companies are currently involved in the production of 6-chloro-2,3-diaminopyridine, and the production technology is constantly being optimized and improved, and the production scale is also expanding. However, due to the rapid growth of downstream demand, there may still be a certain supply and demand gap in the short term.
    To sum up, 6-chloro-2,3-diaminopyridine has a very promising market prospect due to strong demand from downstream industries such as pharmaceuticals, pesticides and materials. Although supply is also growing, it will continue to maintain strong demand for some time in the future, and it is a product with great potential in the chemical industry.