6-Chloro-1H-pyrazolo[4,3-c]pyridine

6-Chloro-1H-pyrazolo [4,3-c] pyridine is one of the organic compounds. It has a wide range of uses and is often a key intermediate in the synthesis of many biologically active drug molecules in the field of medicinal chemistry.
The history of drug development and the creation of many new therapeutic drugs often rely on such compounds as starting materials. Due to its unique chemical structure, it can impart specific activities and properties to drug molecules, helping to regulate specific physiological processes in organisms, or combine with specific targets, and then exert the effect of treating diseases.
In the field of pesticide chemistry, 6-chloro-1H-pyrazolo [4,3-c] pyridine is also important. It can be used as an important component for the synthesis of new pesticides. By modifying and modifying its structure, pesticide products with high insecticidal, bactericidal or herbicidal properties can be developed, and such pesticides may have environmentally friendly and low toxicity characteristics, which is conducive to the sustainable development of agriculture.
In addition, in the field of materials science, based on this compound, through specific reactions and treatments, materials with special optical and electrical properties can be prepared, which can be used in many emerging technologies such as photoelectric displays and sensors.
From this perspective, although 6-chloro-1H-pyrazolo [4,3-c] pyridine is an organic compound, it has shown significant application value and development potential in many key fields such as medicine, pesticides, and materials. It is an indispensable and important substance in chemical research and industrial production.

6-Chloro-1H-pyrazolo [4,3-c] pyridine is an organic compound. Its physical properties are important for its application in many fields.
Under normal temperature and pressure, it is mostly in a solid form, which is convenient for storage and transportation, and also affects the way it participates in the reaction. Its color is usually white to light yellow powder or crystal, and this color characteristic can be used as the basis for preliminary identification.
The melting point is about 150-155 ° C. The determination of the melting point is a key indicator for identifying the compound and considering its thermal stability. When the temperature reaches this range, the substance changes from solid to liquid, and this process needs to absorb heat, reflecting the strength of intermolecular forces.
In terms of solubility, 6-chloro-1H-pyrazolo [4,3-c] pyridine has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). In dichloromethane, because its molecular structure matches the polarity of dichloromethane, it can be well dispersed and dissolved. This property makes it in organic synthesis, if dichloromethane is used as the reaction solvent, it can fully participate in the reaction. In water, the solubility is poor, because the molecular polarity is quite different from the strong polarity of water, and the hydrogen bonding between water molecules is strong, which hinders the molecular dispersion of the compound.
Furthermore, its density is also an important physical property. Although the exact value needs to be determined by precise experiments, the approximate density range is helpful to evaluate its distribution in different systems, such as in mixed solvent systems, which can be used to judge its stratification or dispersion state.
The physical properties of this compound, in the field of organic synthesis, assist chemists in designing reaction conditions, selecting suitable solvents and reaction temperatures; in drug development, it affects the pharmacokinetic properties of drug absorption, distribution and metabolism, which is of great significance for the creation of high-efficiency and low-toxicity drugs.

The synthesis method of 6-chloro-1H-pyrazolo [4,3-c] pyridine is described in the past books and is roughly as follows.
First, it can be started by a specific pyridine derivative. Take a suitable pyridine derivative and add a specific halogenating agent, such as a chlorine-containing halogenating agent, into a suitable reaction vessel. Control the reaction temperature, pressure and reaction time to make the halogenation reaction occur smoothly. This process requires precise control of the reaction conditions. If the temperature is too high or too low, it may affect the substitution of halogen atoms at a specific position of the pyridine ring, resulting in impure products or low yields.
Second, the method of constructing through the pyrazole ring. First, the structure of the pyrazole ring is constructed by a series of reactions such as condensation and cyclization with suitable nitrogen-containing raw materials. This step may require the participation of specific catalysts to accelerate the reaction process and improve the reaction selectivity. Subsequently, on the basis of the pyrazole ring, it is connected to the pyridine-related fragments to form the target pyrazolo [4,3-c] pyridine structure. During this period, attention should also be paid to the optimization of the reaction conditions of each step, such as the proportion of reactants, solvent selection, etc. The polarity and solubility of the solvent have a great impact on the reaction path and product distribution.
Third, the strategy of using transition metal catalysis. The introduction of specific transition metal catalysts, such as complexes of metals such as palladium and copper, with their unique catalytic activity, guides the reactants to react according to the expected path. This method often needs to be matched with suitable ligands to enhance the activity and selectivity of metal catalysts. In the reaction, the purity of the reaction system is quite high, and impurities or catalysts cause poisoning, reducing catalytic efficiency and affecting the formation of target products.
The above synthesis methods have their own advantages and disadvantages, and need to be weighed according to actual conditions, such as raw material availability, cost considerations, product purity requirements, etc., in order to achieve the desired synthesis effect.

The market price of 6-chloro-1H-pyrazolo [4,3-c] pyridine is difficult to determine. This is due to various reasons, resulting in fluctuations in its price range.
First, the price of raw materials often changes. The preparation of 6-chloro-1H-pyrazolo [4,3-c] pyridine requires all kinds of raw materials. If the production of raw materials changes and supply and demand are out of balance, the price will change. If a raw material production area is damaged, the output will drop sharply, and the supply will not meet the demand, the price will rise, which has a significant impact on the price of 6-chloro-1H-pyrazolo [4,3-c] pyridine.
Second, the preparation method is also the key. If there are new production techniques that can reduce the cost and yield, the price may drop. On the contrary, if the manufacturing process is complicated, the energy consumption is high, the cost increases, and the price is also high.
Third, market supply and demand determine the price. If in the fields of medicine, chemical industry, etc., the demand for this product increases sharply, but the supply is not enough, and the price rises. On the contrary, if the demand is weak and the inventory is accumulated, the price will decline.
Fourth, regional differences should not be underestimated. Different places have different prices due to different taxes, logistics and other fees. In prosperous cities, due to convenient business flow and strong demand, the price may be high; in remote places, due to inconvenient logistics and low demand, the price may be low.
Looking at the general market conditions, the price of 6-chloro-1H-pyrazolo [4,3-c] pyridine fluctuates roughly between tens of yuan and hundreds of yuan per gram. But this is only an approximate number. To know the exact price, you need to carefully observe the real-time market conditions and consult chemical raw material suppliers or similar platforms.

6-Chloro-1H-pyrazolo [4,3-c] pyridine is also an organic compound. Its storage conditions are crucial, related to the stability and quality of this substance.
This substance should be stored in a cool place, because high temperature can easily cause its chemical properties to change. If it is hot in the summer, its molecular structure may change, which will damage its inherent properties. And should be placed in a dry place, protected from moisture. Water and wet gas are often the cause of deterioration of many compounds, or cause reactions such as hydrolysis, resulting in impurity.
Furthermore, it needs to be stored in a well-ventilated place. If the space is blocked, the gas emitted by the compound cannot be dissipated in time, or it is dangerous to gather, and it is not conducive to its long-term storage. Storage places should also be kept away from fires and heat sources, because they have certain chemical activity, in case of open flames and hot topics, there is a risk of combustion and explosion.
In addition, 6-chloro-1H-pyrazolo [4,3-c] pyridine should be stored separately from oxidizing agents, acids, bases, etc., and must not be mixed. Mixing of different chemical properties is easy to cause chemical reactions, or has unpredictable consequences.
In conclusion, proper storage of 6-chloro-1H-pyrazolo [4,3-c] pyridine should be kept in a cool, dry, and ventilated place, away from fire and heat sources, and separated from incompatible materials, so as to maintain its stability for future use.