6-bromopyridine-3-carboxamide

6-Bromopyridine-3-formamide, its chemical structure, is based on the pyridine ring. The pyridine ring is a nitrogen-containing hexamembered heterocycle, which is aromatic. At the 6th position of the pyridine ring, it is connected to a bromine atom, which is a halogen element with specific chemical activity. At the 3rd position of the pyridine ring, it is connected to a formamide group. The structure of the formamide group is that the carbonyl group (C = O) is connected to the amino group (-NH2O), and then to the carbon at the 3rd position of the pyridine ring.
The structure of this compound makes the parts interact with each other. Bromine atoms can affect the electron cloud distribution of pyridine rings due to their electronegativity, which in turn affects their reactivity and chemical properties. Formamyl groups also play a role in the electron cloud of pyridine rings, and their own carbonyl and amino groups can participate in a variety of chemical reactions, such as nucleophilic substitution, condensation and other reactions. Overall, the chemical structure of 6-bromopyridine-3-formamide gives it unique chemical properties and reactivity, and may have important uses and research value in organic synthesis and pharmaceutical chemistry.

6-Bromopyridine-3-formamide is widely used in the field of medicinal chemistry. First, it can be used as a key intermediate in organic synthesis. In the process of drug development, many bioactive compounds rely on it to build specific pyridine structures. For example, by reacting with different nucleophiles, such as amines, alcohols, etc., it can form multiple complex derivatives, or have various pharmacological activities such as antibacterial and anti-inflammatory.
Second, it also has its uses in the field of materials science. Its structural properties may endow materials with unique optical and electrical properties. For example, in the preparation of organic optoelectronic materials, appropriate modification can be used to access the macromolecular system, which may improve the charge transport ability and luminous efficiency of the material, and is expected to be applied to organic Light Emitting Diode (OLED), solar cells and other devices.
Third, in the field of agricultural chemistry, this is used as the starting material to synthesize new pesticides through a series of reactions. Such pesticides may have high efficiency, low toxicity and environmentally friendly characteristics, which can effectively control crop diseases and pests and ensure crop growth and yield.
Fourth, in the level of scientific research and exploration, as an important chemical reagent, it helps chemists to deeply study the reaction mechanism and chemical properties of pyridine compounds. By carefully exploring the various reactions in which it participates, it can provide an empirical basis for the theoretical development of organic synthetic chemistry and expand a new path of chemical synthesis.

The synthesis method of 6-bromopyridine-3-formamide has been explored by many parties throughout the ages, and various methods have been developed.
First, 6-bromopyridine-3-carboxylic acid is used as the starting material. First, 6-bromopyridine-3-carboxylic acid is placed in a suitable reaction vessel, and an appropriate amount of dichlorosulfoxide is added. This dichlorosulfoxide is like a weapon in the hands of skilled craftsmen, which can convert the acid into acid chloride. When the reaction is completed, it is necessary to pay attention to the regulation of temperature. Generally, under the condition of heating and reflux, the two can fully react. After the reaction is completed, remove the excess dichlorosulfoxide, and then This concentrated ammonia water is like a spring rain moisturizer. It interacts ingeniously with acyl chloride to eventually form 6-bromopyridine-3-formamide. This process requires careful operation, because sulfoxide is corrosive and harmful gases may be generated during the reaction.
Second, 6-bromo-3-cyanopyridine is used as the starting material. 6-bromo-3-cyanopyridine is placed in the reaction system, and an appropriate amount of alkaline solution, such as sodium hydroxide solution, is added. At a suitable temperature, the cyanyl group undergoes hydrolysis in an alkaline environment, which is like a silkworm cocoon breaking into a butterfly and gradually converts into an amide group. After the reaction is completed, pure 6-bromopyridine-3-formamide can be obtained through post-treatment steps such as acidification. In this method, the concentration of the alkaline solution, the reaction temperature and time all have a great impact on the reaction result, and precise control is required.
Third, synthesize through the construction of pyridine rings. Select suitable bromopyridine and carboxyl precursor compounds, and use organic synthesis skills to construct a pyridine ring structure. For example, using some nitrogen-containing, bromopyridine-containing and carboxyl-containing small molecules, under specific catalyst and reaction conditions, cyclize to form a pyridine ring, and then obtain 6-bromopyridine-3-formamide. Although this method is a bit complicated, it can flexibly design the molecular structure according to the requirements, but it requires high reaction conditions and catalysts.

6-Bromopyridine-3-formamide is also an organic compound. Its physical properties are quite important, so let me come one by one.
Looking at its properties, it is mostly white to white solid powder under normal circumstances. This form is easy to store and use, and is easy to measure and operate in many experiments and industrial processes.
When it comes to the melting point, it is about 185-189 ° C. The melting point is an inherent property of the substance. At this temperature, the compound gradually melts from a solid state to a liquid state. This property can be used to identify the purity. If the purity is high, the melting point range is relatively narrow and approaches the theoretical value; if it contains impurities, the melting point may be reduced and the melting range will be widened.
Its solubility also has characteristics. In common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., it has a certain solubility. In dichloromethane, due to the adaptation of the forces between the molecules, it can be better dissolved, which is conducive to the reaction with this solvent. In water, the solubility is relatively small, because although there are amide groups in the molecular structure that can form hydrogen bonds with water, the hydrophobicity of bromine atoms and pyridine rings limits its solubility in water.
In addition, the density, boiling point and other properties of the compound are also related to many reactions and separation processes. The density determines its distribution position in the mixed system, and the boiling point is related to the setting of separation conditions such as distillation.
The physical properties of 6-bromopyridine-3-formamide are of great significance in the fields of organic synthesis and drug development, and researchers need to consider in detail to make good use of this compound.

The price of 6-bromopyridine-3-formamide in the market is difficult to determine. This is due to various reasons, resulting in fluctuations in its price range.
Let's talk about the situation of supply and demand first. If there are many people in the market, but the supply is small, the price will rise; if the demand is scarce, the supply is sufficient, and the price may decline. If at some point, the pharmacy needs a big increase in it, and the producer has not expanded production, the price will rise.
Furthermore, the manufacturing cost is also a major factor. The price of raw materials, labor costs, energy consumption, etc. are all related to the cost. If the price of raw materials rises, or labor costs increase, the cost will be high, and the selling price will also rise accordingly. For example, if the price of raw bromine rises sharply, the manufacturing cost of 6-bromopyridine-3-formamide will increase sharply, and the market price will also rise.
The difference between the origin and the quality also affects the price. Different origins, due to different technologies and environments, may vary in quality. High quality, the price is often higher. For example, European and American refined products, the price may be several percent higher than that of ordinary origins.
At present, the price of 6-bromopyridine-3-formamide in the market ranges from tens of yuan to hundreds of yuan per gram. Small purchases, due to logistics, packaging and other costs, the unit price may be high; bulk purchases, due to scale effects, the unit price may be slightly lower. Buyers should widely observe market conditions and compare and choose various companies to get a suitable price.