6-Bromopyridine-2-carbaldehyde

6-Bromopyridine-2-formaldehyde is a crucial intermediate in organic synthesis and has a wide range of uses in many fields.
First, in the field of medicinal chemistry, it can be a key structural unit. The construction of many drug molecules often depends on this compound. Due to its unique activity of the pyridine ring with aldehyde and bromine atoms, it can be cleverly connected with other groups through a variety of chemical reactions to construct molecules with specific pharmacological activities. For example, new drug candidates can be derived through the reaction of aldehyde groups and condensation with compounds containing amino or hydroxyl groups, which can be used for the development of antibacterial, anti-tumor and other drugs.
Second, in the field of materials science, 6-bromopyridine-2-formaldehyde also has extraordinary performance. It can participate in the synthesis of polymer materials. Bromine atoms can be used as reaction check points. Through polymerization, the structure of pyridinal is introduced into the polymer chain, giving the material special optical, electrical or mechanical properties. For example, the preparation of polymer materials with fluorescent properties is used in sensors or light-emitting devices.
Furthermore, in the field of organic synthesis chemistry, it can participate in many classical organic reactions as an important intermediate. For example, through the nucleophilic substitution reaction of bromine atoms, different functional groups are introduced to expand the structural diversity of molecules. The aldehyde group can also perform reactions such as Wittig reaction and hydroxyaldehyde condensation reaction, providing an effective way for the construction of complex organic molecules and assisting organic synthesis chemists in synthesizing various target products.

The synthesis method of 6-bromopyridine-2-formaldehyde has been known in ancient times, and the above numbers are present.
First, 6-bromopyridine-2-formic acid is used as the starting material. First, 6-bromopyridine-2-formic acid and lithium aluminum hydride are reacted slowly in a suitable solvent, such as anhydrous tetrahydrofuran, in a low temperature environment. Lithium aluminum hydride has strong reductivity and can reduce carboxyl groups to hydroxyl groups to obtain 6-bromopyridine-2-methanol. Then a suitable oxidant, such as Dice-Martin oxidant, is mildly oxidized in a dichloromethane solvent to oxidize the hydroxyl group to an aldehyde group, and then 6-bromopyridine-2-formaldehyde is obtained.
Second, 2-methyl-6-bromopyridine is used as the starting material. First, N-bromosuccinimide (NBS) is used as the bromination reagent, and in a carbon tetrachloride solvent, under the action of an initiator, such as benzoyl peroxide, the reaction is heated to make methyl bromide to obtain 6-bromopyridine. The product is then reacted with urotropine to form a quaternary ammonium salt. After acidic hydrolysis, 6-bromopyridine-2-formaldehyde can be obtained.
Third, 6-bromopyridine-2-halopyridine is used as raw material. React with metal magnesium to make Grignard reagents, such as 6-bromopyridine-2-chloropyridine reacts with magnesium in anhydrous ether to form corresponding Grignard reagents. After reacting with N, N-dimethylformamide (DMF), after hydrolysis, 6-bromopyridine-2-formaldehyde can also be obtained. Each of these methods has its own advantages and disadvantages, and it is necessary to choose the best and use them according to the actual situation.

6-Bromopyridine-2-formaldehyde is one of the organic compounds. Its physical properties are quite critical and of great significance in chemical synthesis and other fields.
Looking at its properties, under room temperature and pressure, 6-bromopyridine-2-formaldehyde mostly shows a light yellow to yellow solid state. This appearance feature is convenient for identification and preliminary judgment. Its melting point is about 58-62 ° C, and the melting point is relatively stable. It will undergo a solid-to-liquid transition at a specific temperature, providing a reference for its processing and application.
In terms of solubility, 6-bromopyridine-2-formaldehyde is soluble in common organic solvents, such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. However, its solubility in water is very small, and this property determines its reaction and separation in different solvent systems. For example, in organic synthesis reactions, the selection of suitable organic solvents can promote the reaction.
The boiling point of 6-bromopyridine-2-formaldehyde is about 265-267 ° C under certain pressure conditions. The characteristics of boiling point are related to its distillation and purification operations. In the chemical production process, by controlling temperature and pressure, it can effectively realize the separation and purification of substances.
In addition, the compound has a certain odor. Although it is not stinky and pungent, it has its own unique smell. However, the odor description is more subjective, and different people may perceive it differently.
The physical properties of 6-bromopyridine-2-formaldehyde are interrelated and have guiding value for its storage, transportation, reaction conditions setting, etc., and play an important role in organic chemistry research and related industries.

6-Bromopyridine-2-formaldehyde is an organic compound with special chemical properties and is widely used in the field of organic synthesis.
In terms of physical properties, it is mostly solid at room temperature, but the specific properties are also affected by factors such as purity. The substance has a certain polarity due to the presence of bromine atoms and aldehyde groups. It has good solubility in organic solvents such as ethanol and dichloromethane, but poor solubility in water.
In terms of chemical properties, aldehyde groups have high activity and can participate in a variety of reactions. One is oxidation reaction. Under the action of suitable oxidants, aldehyde groups can be oxidized to carboxyl groups to form 6-bromopyridine-2-carboxylic acids. The second is a reduction reaction. When treated with a suitable reducing agent, the aldehyde group can be converted into a hydroxyl group to obtain 6-bromopyridine-2-methanol. The third is a condensation reaction. The aldehyde group can condensate with compounds containing active hydrogen, such as amines and alcohols, to form imines or acetal compounds.
Furthermore, the bromine atom also gives the compound unique reactivity. The bromine atom can undergo a nucleophilic substitution reaction. In the presence of a suitable nucleophilic reagent, the bromine atom can be replaced by other groups, thereby introducing new functional groups to expand the structure and properties of the compound. For example, when reacting with sodium alcohol, the bromine atom can be replaced by an alkoxy group; when reacting with sodium cyanide, a cyano group can be introduced.
In addition, in 6-bromopyridine-2-formaldehyde molecules, the pyridine ring has aromatic properties and can participate in aromatic electrophilic substitution reactions. Due to the influence of bromine atoms and aldehyde groups, the reaction check point and activity show specific rules. In many organic synthesis reactions, this compound is often used as a key intermediate for the preparation of many important organic compounds in the fields of drugs, pesticides, materials, etc.

6-Bromopyridine-2-formaldehyde is on the market, and its price range is difficult to determine. The price of this product often changes for many reasons, one of which is the situation of supply and demand. If there are many applicants and few suppliers, the price will increase; on the contrary, if the supply exceeds the demand, the price may drop. Second, the cost of production is also a major factor. The price of raw materials, the level of labor costs, and the wear and tear of equipment are all related to its cost, which in turn affects the selling price. Third, the difference in quality also leads to different prices. Those with high purity often have higher prices than those with low purity.
Looking at the market in the past, the price of this product fluctuates within a certain range. However, due to changes in times, it is difficult to say its exact value. In the market of chemical raw materials, it can range from hundreds to thousands of yuan per kilogram. If the purchase volume is huge, the merchant may give a discount, and the price may be lower. And different suppliers have different prices. Those who are well-known and good-faith may have slightly higher prices, but their quality and after-sales may be better. For details, consult chemical raw material suppliers, or refer to professional market reports, to get the current accurate price.