6-bromoH-pyrazolo[1,5-a]pyridine-2-carboxylic acid

6 - bromoH - pyrazolo [1,5 - a] pyridine - 2 - carboxylic acid is one of the organic compounds. Its chemical structure can be resolved as follows:
The core of this compound is the ring system of pyrazolo [1,5 - a] pyridine. Pyrazolo [1,5 - a] pyridine ring is formed by fusing a pyrazolo ring with a pyridine ring. The pyrazolo ring has a five-membered ring structure containing two adjacent nitrogen atoms; the pyridine ring is a six-membered ring containing one nitrogen atom. After fusing, the two form a unique dicyclic structure. < Br >
In the sixth position of the ring system, there is a bromo atom connected. The bromo atom has strong electronegativity, which has a great influence on the physical and chemical properties of the molecule. It can affect the polarity and reactivity of the molecule.
And in the second position, there is a carboxylic acid. The carboxylic group is a strong polar group and can participate in a variety of chemical reactions, such as salt-forming reactions, esterification reactions, etc. The existence of this carboxylic group endows the molecule with a certain acidity, and also has a significant effect on the solubility and biological activity of the molecule.
In summary, the chemical structure of 6-bromoH-pyrazolo [1,5-a] pyridine-2-carboxylic acid is composed of a specific pyrazolo [1,5-a] pyridine ring system combined with a bromine atom at position 6 and a carboxylic group at position 2. The interaction of various structural parts determines the unique properties and reactivity of the compound.

6-BromoH-pyrazolo [1,5-a] pyridine-2-carboxylic acid, which is 6-bromo-H-pyrazolo [1,5-a] pyridine-2-carboxylic acid, is widely used. In the field of pharmaceutical chemistry, it can be used as a key intermediate to help create new drugs. Due to its unique chemical structure, it can interact with specific targets in organisms, laying the foundation for the development of innovative drugs with high efficiency and low toxicity.
In the field of materials science, this compound may be used to prepare functional materials with special properties. For example, through specific chemical modification and processing, materials can be endowed with unique optical and electrical properties, making them stand out in the fields of organic Light Emitting Diodes and sensors.
In the field of organic synthetic chemistry, 6-bromo-H-pyrazolo [1,5-a] pyridine-2-carboxylic acid is also an important synthetic block. With its active bromine atoms and carboxyl groups, complex organic molecules can be constructed through various chemical reactions, such as nucleophilic substitution, esterification reactions, etc., which greatly expand the boundaries of organic synthesis and contribute to the development of organic chemistry.
In summary, 6-bromo-H-pyrazolo [1,5-a] pyridine-2-carboxylic acids have important applications in many fields such as medicine, materials and organic synthesis, and are a class of organic compounds that cannot be ignored.

The synthesis method of 6-bromoH-pyrazolo [1,5-a] pyridine-2-carboxylic acid, that is, 6-bromo-H-pyrazolo [1,5-a] pyridine-2-carboxylic acid, has also been studied by ancient alchemists.
One method is to carboxylate the second position of the pyridine ring with pyrazolo [1,5-a] pyridine as the group. Appropriate carboxylate reagents, such as carbon dioxide, can be selected to react with it under suitable bases and catalytic systems. In this step, attention should be paid to the temperature and pressure of the reaction. The temperature should be controlled in the range of low temperature to medium temperature, and the pressure may need to be slightly increased to promote the carboxylation.
Then, bromine atoms are introduced at the 6 position of the pyrazole ring. This can be achieved by halogenation. Commonly used brominating reagents, such as N-bromosuccinimide (NBS), in the presence of initiators such as benzoyl peroxide, can selectively replace hydrogen atoms at the 6 position by bromine atoms under light or heating. During the reaction, the choice of solvent is very critical. Aprotic solvents such as carbon tetrachloride may be good choices, which can help the reaction occur smoothly and are beneficial to the selectivity of the reaction. < Br >
Another method can be used to introduce bromine atoms at the 6th position of pyrazolo [1,5-a] pyridine first, and then carboxylation at the 2nd position. The bromination steps are as above, and the carboxylation can choose different paths depending on the situation. Or use a metal-organic reagent, such as Grignard's reagent, to react with carbon dioxide, and then acidify to obtain a carboxyl group; or use a cyano-substituted hydrolysis method to form a carboxyl group, that is, introduce a cyano group first, and then hydrolyze it into a carboxyl group under the catalysis of an acid or base.
These various synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to actual conditions, such as the availability of raw materials, cost considerations, and the operability of the reaction.

6-BromoH-pyrazolo [1,5-a] pyridine-2-carboxylic acid, Chinese name or 6-bromo-H-pyrazolo [1,5-a] pyridine-2-carboxylic acid. This physical property may have the following characteristics:
It is an organic compound with bromine atom, pyrazolopyridine and carboxylic acid structure. In terms of physical properties, it is a solid under normal conditions. Due to the presence of aromatic rings and polar carboxylic groups, the intermolecular force is strong, and the melting point is high. However, there is no exact data to clarify its specific melting point. < Br >
In terms of solubility, due to its polar carboxyl group, it may have a certain solubility in polar solvents such as methanol, ethanol, and water (but carboxylic acids need to be ionized to be better soluble). And because of the hydrophobic aromatic ring structure, the solubility in non-polar solvents such as n-hexane and benzene may be limited.
Its appearance may be white to light yellow powder or crystal, and it may have certain stability due to the conjugated aromatic ring system. However, the bromine atom has high activity, or can participate in a variety of chemical reactions, resulting in a slight decrease in its chemical stability.
The pyrazopyridine, bromine, and carboxyl structures of this substance make it potentially useful in the fields of medicinal chemistry and materials science. In medicinal chemistry, it may be a key intermediate for the synthesis of new drugs; in materials science, it may be used to prepare materials with special optoelectronic properties.

6 - bromoH - pyrazolo [1,5 - a] pyridine - 2 - carboxylic acid, that is, 6 - bromo - H - pyrazolo [1,5 - a] pyridine - 2 - carboxylic acid, this product is in the market price, it is difficult to say. The change in its price is subject to various factors. < Br >
First, the price of raw materials. If the price of all raw materials required for the synthesis of this acid varies with the market, or the price rises and falls due to the origin, season, supply and demand, then the cost of 6-bromo-H-pyrazolo [1,5-a] pyridine-2-carboxylic acid also changes, and the price varies.
Second, the method of preparation and the degree of complexity. If the preparation requires delicate equipment, complicated steps, and time-consuming, the cost will be high and the price will be high. If the method is simple, the cost will decrease, and the price will be low.
Third, the situation of supply and demand, the market demand is large, and the supply is small, the price will rise; if the supply exceeds the demand, the price will decline.
Fourth, the quality, high purity, high quality, the price must be higher than the ordinary.
From this perspective, the price of 6-bromo-H-pyrazolo [1,5-a] pyridine-2-carboxylic acid in the market, or in the number of yuan per gram to hundreds of yuan, it is difficult to determine the exact number, and it must be determined according to the specific time, place and the above factors.