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What is the chemical structure of 6-bromoH-imidazo [1,2-a] pyridine-3-carbaldehyde
6 - bromoH - imidazo [1,2 - a] pyridine - 3 - carbalaldehyde is also a compound. Its molecules are characterized by fused systems containing imidazolo-pyridine.
The core part of this compound is the imidazolo [1,2 - a] pyridine skeleton. Imidazoles are five-element nitrogen-containing compounds, with dinitrogen atoms, which are rich in children and can be polarized. Pyridine and six-element nitrogen-containing compounds also have special properties. The two fuse to form imidazolo [1,2 - a] pyridine, which increases the qualitative reaction activity of the molecule.
In the 6th position of the imidazolo [1,2-a] pyridine skeleton, there is a bromine atom. The bromine atom has the effect of an absorber, which can affect the sub-cloud of the molecule, and change its physical and chemical properties. Bromine atoms also have important functions, which can be derived through multiple reactions, such as nuclear substitution reaction.
Furthermore, there is an aldehyde group (-CHO) at the 3rd position. The aldehyde group is functional and has a high degree of reaction activity. The aldehyde group can be oxidized, original, nuclear addition, etc., and has a wide range of uses in the synthesis of molecules. The aldehyde-imidazolopyridine skeleton interacts with the bromine atom, and the 6-bromoH-imidazo [1,2-a] pyridine-3-carbalaldehyde is specially synthesized. In addition, the chemical is composed of imidazolopyridine fused system, 6-position bromine atom and 3-position aldehyde group, and each part is influenced by each other to determine its anti-activity.
What are the main uses of 6-bromoH-imidazo [1,2-a] pyridine-3-carbaldehyde
6-BromoH-imidazo [1,2-a] pyridine-3-carbalaldehyde is one of the organic compounds. It is widely used in the field of medicinal chemistry and is often a key intermediate in the synthesis of many drugs. Taking the creation of new drugs for the treatment of specific diseases as an example, the unique structure of this compound allows it to participate in a series of chemical reactions and help build molecular structures with specific biological activities.
In the field of materials science, it may be used to develop new functional materials. Its chemical activity and structural properties may endow materials with unique optical, electrical or other physicochemical properties, such as in the preparation of organic optoelectronic materials, to improve the performance of materials.
In organic synthetic chemistry, 6-bromoH-imidazo [1,2-a] pyridine-3-carbalaldehyde also plays an important role. Because of its active functional groups such as bromine atoms and aldehyde groups, it can initiate a variety of chemical reactions, such as nucleophilic substitution reactions, redox reactions, etc., providing an effective way for the synthesis of complex organic molecules, and assisting chemists in constructing a rich and diverse library of organic compounds for subsequent research and application.
What are the synthesis methods of 6-bromoH-imidazo [1,2-a] pyridine-3-carbaldehyde
6 - bromoH - imidazo [1,2 - a] pyridine - 3 - carbalaldehyde, organic compounds are also. The synthesis method has been known since ancient times, and is described as follows.
First, a suitable pyridine derivative is used as the starting material. Introduce bromine atoms at a specific position of the pyridine ring first. In this step, select an appropriate bromination reagent, such as liquid bromine or N - bromosuccinimide (NBS), and control the temperature and time, so that the bromination reaction precisely occurs at the target check point.
Then, the structure of imidazolopyridine is constructed. Often by means of condensation reaction, it reacts with nitrogen-containing heterocyclic precursors under specific conditions, either catalyzed by strong bases or refluxed at high temperatures, to promote the cyclization of molecules to form imidazolo-pyridine skeletons.
Finally, the aldehyde group is introduced at the pyridine-3-position. A mild formylating agent, such as Vilsmeier-Haack reagent combined with DMF and POCl, can be used to gradually react at low temperatures to successfully connect the aldehyde group.
Second, another approach can also be found. Starting from the aldehyde-containing pyridine analogs, the pyridine ring is modified first, and the necessary substituents are added, and then the imidazole ring is constructed by cyclization reaction. During the process, the reaction conditions are carefully regulated to preserve the integrity of the aldehyde group and allow the imidazole ring to form at the expected position.
Third, some heterocyclic compounds are used as the starting materials. Through a multi-step reaction, the carbon chain is first expanded, nitrogen atoms are introduced, and the basic structure of imidazole-pyridine is gradually established. Then bromine atoms and aldehyde groups are introduced at an appropriate stage. This path requires fine planning of the reaction sequence and conditions of each step to make the conversion proceed smoothly.
All these synthesis methods require attention to the precise control of reaction conditions. The selection of solvents, the amount of catalysts, and the regulation of temperature and time all affect the yield and purity of the product, so care must be taken.
What are the physical properties of 6-bromoH-imidazo [1,2-a] pyridine-3-carbaldehyde
6 - bromoH - imidazo [1,2 - a] pyridine - 3 - carbalaldehyde is an organic compound. Its physical properties are as follows:
At room temperature, this substance is either a solid or a viscous liquid, but the exact state depends on the characteristics of intermolecular forces and molecular arrangement. Its color is either colorless or yellowish, which is caused by the interaction of atoms and chemical bonds contained in the molecular structure.
When it comes to the melting point, the intermolecular force is the key factor. The structure of the fusion of bromine atoms, aldehyde groups and imidazopyridine in the molecule makes the intermolecular force quite complex. Bromine atoms have a large atomic radius and electronegativity, which can cause strong dispersion force and dipole-dipole force between molecules; the polarity of the carbon and oxygen double bonds in the aldehyde group enhances the intermolecular interaction. Therefore, its melting point and boiling point are relatively high, because more energy is required to overcome the intermolecular force, so that the substance melts from solid to liquid, and then gasifies into gaseous state.
In terms of solubility, the solubility of the compound in organic solvents depends on the interaction between the solvent and the solute. Because it contains polar aldehyde groups, it may have better solubility in polar organic solvents, such as ethanol and acetone, because the solute and the solvent can form hydrogen bonds or dipole-dipole interactions. However, in non-polar solvents, such as n-hexane, the solubility may be poor, due to the weak interaction between the non-polar solvent and the non-polar solvent.
Furthermore, its density is also related to the molecular structure and atomic weight. The atomic weight of bromine atoms is large, and the specific structure of the molecule may make its density relatively large, which is heavier than that of common organic solvents.
The physical properties of this compound are determined by its unique molecular structure. In the fields of organic synthesis, medicinal chemistry, etc., the mastery of its properties is extremely important, and it is related to the choice of reaction conditions, the separation and purification of products, and many other aspects.
6-BromoH-imidazo [1,2-a] What is the market outlook for pyridine-3-carbaldehyde?
6-BromoH-imidazo [1,2-a] pyridine-3-carbalaldehyde, which is an organic compound, or 6-bromo-H-imidazolo [1,2-a] pyridine-3-formaldehyde in Chinese. Its market prospect is considerable and complex, and it has a multi-faceted situation.
Let's talk about its positive aspects first. In the field of pharmaceutical research and development, such nitrogen-containing heterocyclic compounds often have unique biological activities or are key intermediates for the creation of new drugs. Nowadays, the pharmaceutical industry is thirsty for novel active ingredients, and continues to explore new drugs with high efficiency and low toxicity. Due to its structural characteristics, this compound may emerge in the development path of antibacterial, antiviral, anti-tumor and many other drugs. Therefore, the demand in the pharmaceutical field may be increasing, paving the way for its market.
Furthermore, there are also opportunities in the field of materials science. With the evolution of science and technology, the demand for materials with special properties is increasing. Materials containing this compound may be modified and modified to exhibit unique optical and electrical properties, finding a place in cutting-edge fields such as optoelectronic materials and opening up new market spaces.
However, its market also has challenges. During the organic synthesis process, the preparation of this compound may pose problems. The complex structure results in cumbersome synthesis steps and high costs. If the cost is not well controlled, large-scale production and marketing activities will be hindered. And the market competition is fierce, with similar structural or functional compounds emerging in an endless stream. If the R & D progress is slow and the technical advantage is difficult to establish, it is easy to be submerged by the market torrent.
Overall, the market prospect of 6-bromoH-imidazo [1,2-a] pyridine-3-carbalaldehyde coexists with gloom. With structural advantages, it may create a new situation in the fields of medicine and materials; however, synthesis costs and competitive pressures are also fetters. Only by refining the synthesis process and strengthening R & D innovation can we gain an advantage in the market game and bloom.