6-Bromo-pyridine-2-carbonitrile

6-Bromo-pyridine-2-formonitrile is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of organic synthesis.
First, in pharmaceutical chemistry, it can be used as a starting material for the synthesis of many drugs. Gai can participate in various chemical reactions to construct molecular structures with specific pharmacological activities due to its structural properties of pyridine and nitrile groups. For example, in the development of antibacterial and antiviral drugs, by modifying their structures and adding suitable functional groups, or lead compounds with good biological activity and pharmacokinetic properties can be obtained.
Second, in the field of materials science, it also has important uses. It can be introduced into the structure of polymer materials through specific reactions to improve the properties of materials. Such as improving the stability, conductivity or optical properties of materials. For example, in the preparation of some organic optoelectronic materials, 6-bromo-pyridine-2-formonitrile can give the material better photoelectric conversion efficiency through rational design reactions.
Third, in the field of pesticide chemistry, it is also an important synthetic block. It can be used to create new pesticides. By chemically modifying them, pesticide varieties with high efficiency, low toxicity and environmental friendliness can be developed to meet the needs of pest control in agricultural production.
In summary, 6-bromo-pyridine-2-formonitrile plays an important role in many fields, such as organic synthesis, drug development, materials science, and pesticide creation, due to its unique chemical structure. It has made significant contributions to the development of various fields.

The synthesis method of 6-bromopyridine-2-formonitrile has been explored by many talented people throughout the ages. The common route is to use pyridine-2-formonitrile as the initial raw material and can be obtained by bromination. The method is mostly liquid bromine, N-bromosuccinimide (NBS), etc. as bromination reagents.
If liquid bromine is used, an appropriate amount of catalyst, such as iron powder or iron tribromide, is added to a suitable solvent such as dichloromethane. Liquid bromine has good activity and is easy to react, so it is necessary to pay attention to the control of the reaction conditions. If the temperature is high, polybrominated by-products may be generated, so it is often controlled at low temperature, such as 0 ° C to room temperature. At the time of reaction, close monitoring is used. According to the observation of thin layer chromatography (TLC), when the raw materials are exhausted, the reaction is completed. After extraction, washing, drying, column chromatography and other steps, the product is purified.
Using N-bromosuccinimide as a brominating agent is also a commonly used method. This reagent is mild in reaction and has good selectivity. Benzoyl peroxide (BPO) is often used as an initiator to react in inert solvents such as carbon tetrachloride. The reaction temperature is mostly a reflux temperature. During this period, NBS slowly decomposes, releasing bromine radicals, and reacts with pyridine-2-formonitrile. Similarly, by means of TLC monitoring process, the reaction is completed, and a pure 6-bromopyridine-2-formonitrile is obtained by similar post-treatment means.
In addition, 6-aminopyridine-2-formonitrile is used as raw material, first through diazotization reaction, and then with cuprous bromide and other reagents to achieve bromination, but the steps are slightly complicated, which is not as convenient and commonly used as the above two.

6-Bromo-pyridine-2-formonitrile is one of the organic chemicals. Looking at its physical properties, at room temperature, this substance is mostly in a solid state. As for the specific melting point, it is about a specific temperature range, but the exact value still needs to be determined by precise experiments. Its appearance, or white to light yellow crystalline powder, this color state is quite common in organic compounds.
In terms of solubility, 6-bromo-pyridine-2-formonitrile exhibits a certain solubility in organic solvents. It exhibits certain solubility in common organic solvents such as dichloromethane, chloroform, and acetone. This property is due to the molecular structure of the compound, which has specific interactions with organic solvent molecules, such as van der Waals forces, hydrogen bonds, etc., making it dispersible and soluble in such solvents. However, in water, its solubility is very small, because the molecular polarity of the compound is quite different from that of water molecules, it is difficult to form an effective interaction, making it difficult to dissolve in water.
The density of 6-bromo-pyridine-2-formonitrile is also an important physical property. Although the exact density value needs to be accurately determined, roughly speaking, its density is higher than that of water. This property is of great significance in practical applications. When it comes to separation, extraction, etc., an appropriate method can be selected according to this property to achieve the purpose of effective separation and purification.
In addition, the stability of this compound also needs attention. Under normal conditions, 6-bromo-pyridine-2-formonitrile is relatively stable. In case of high temperature, open flame or strong oxidizing agent, or cause chemical reaction, and even lead to dangerous conditions. Therefore, when storing and using, care should be taken to ensure that the environment is suitable and away from the above dangerous factors to ensure safety.

6-Bromopyridine-2-formonitrile, this is an organic compound. Its physical properties are often solid at room temperature, with specific melting points and boiling points, but the exact value varies depending on the preparation and purification conditions.
In terms of chemical properties, due to the presence of bromine atoms and cyano groups, the chemical activity is quite strong. Bromine atoms can undergo many reactions, such as nucleophilic substitution reactions. Under appropriate nucleophilic reagents and reaction conditions, bromine atoms can be replaced by other groups. Taking sodium alcohol as an example, under suitable solvent and temperature, bromine atoms can be replaced by alkoxy groups to form corresponding ether derivatives; when reacted with amine nucleophiles, nitrogen-containing derivatives can be formed, which is used in drug synthesis to construct nitrogen-containing heterocyclic structures, enriching the structure types and biological activities of compounds.
Cyanyl is also an active functional group and can participate in a variety of reactions. In the hydrolysis reaction, under acidic or basic conditions, cyanyl groups can be gradually hydrolyzed into amides, which can then form carboxylic acids. If hydrolyzed under basic conditions, 6-bromopyridine-2-formamide is formed first, and 6-bromopyridine-2-carboxylic acid is obtained after continuing the reaction. Cyanyl groups can also participate in the reduction reaction, and cyanyl groups can be reduced to aminomethyl groups by treatment with specific reducing agents, which can expand the structure and properties of compounds.
6-bromopyridine-2-formonitrile is widely used in organic synthesis and pharmaceutical chemistry due to its unique chemical properties, providing a key intermediate for the synthesis of complex organic molecules and new drugs.

6-Bromo-pyridine-2-formonitrile, the price in the market is difficult to determine. This is due to various reasons, resulting in fluctuations in its price range.
First, the source of materials and the situation of supply and demand are deeply involved. If the raw materials required for its preparation are abundant in origin and available, the price may become stable and cheap; if the raw materials are scarce, the procurement is difficult, and the supply is insufficient, the price will rise.
Second, the simplicity and cost of the process are also important reasons. If the preparation method is simple, the energy consumption is low and the yield is high, the cost will decrease, and the price will follow; on the contrary, if the process is complicated and special equipment and reagents are required, the cost will increase and the price will also increase.
Third, the competition situation of the city has a very small impact. If there are many merchants of this product, the competition is fierce, and there is a strategy to reduce the price in order to compete for the market share; if there are few suppliers, it is a monopoly, and the price may be controllable at a high level.
Fourth, political regulation and taxation also play a role. Strictly regulating or increasing production costs, and changes in taxation can also make the final selling price fluctuate.
Looking at the market conditions, the price of 6-bromo-pyridine-2-formonitrile varies from tens to hundreds of yuan per gram, and it is difficult to determine the exact value. Businesspeople entering the market must carefully observe the market conditions, measure supply and demand, calculate costs, and observe competition in order to obtain a more accurate price and seek business benefits.