6-Bromo-5-methylpyridine-3-boronic acid

6-Bromo-5-methylpyridine-3-boronic acid, which is a class of organoboron compounds. The appearance of this compound is often white to light yellow solid powder, with certain stability, but it is easy to react in strong oxidizing agents and strong alkali environments.
In terms of its chemical activity, boric acid groups are active and can participate in many classic organic reactions, such as the Suzuki coupling reaction. In this reaction, it can be coupled with halogenated aromatics or alkenes in the presence of palladium catalysis and bases, thereby forming carbon-carbon bonds, which are widely used in pharmaceutical synthesis and materials science to prepare complex organic molecules and functional materials.
Its bromine atom is also reactive, and can be replaced by other functional groups, such as amino groups and alkoxy groups, through nucleophilic substitution reactions, thereby expanding the structure and properties of the compound. In addition, the pyridine ring of the substance gives it a certain alkalinity, which can react with acids to form salts. At the same time, the presence of methyl groups affects the electron cloud distribution and spatial structure of the molecule, which affects its physical and chemical properties, such as solubility and melting point. Overall, 6-bromo-5-methylpyridine-3-boronic acid plays an important role in the field of organic synthesis due to its unique chemical properties.

6-Bromo-5-methylpyridine-3-boronic acid is widely used. It is often used as a key intermediate in the field of organic synthesis. Organic synthesis aims to build various complex organic molecules, and this boric acid compound can participate in many key reactions due to its unique structure.
In the construction of carbon-carbon bonds, 6-bromo-5-methylpyridine-3-boronic acid can be coupled with halogenated hydrocarbons, olefins, etc. under the action of suitable catalysts, and palladium catalysts can be used to efficiently generate new carbon-carbon bonds. The construction of specific structural organic compounds is of great significance in the fields of drug development and materials science.
In the field of drug development, the design and synthesis of many drug molecules require the introduction of specific pyridine structures. 6-Bromo-5-methylpyridine-3-boronic acid, as a pyridine derivative, can be modified by subsequent reactions to add specific active groups to drug molecules, optimize drug properties, such as improving solubility, enhancing affinity with targets, and helping to develop new and efficient drugs.
In the field of materials science, it also plays an important role. By participating in organic synthesis reactions, organic materials with special photoelectric properties can be prepared. For example, synthesized materials for organic Light Emitting Diodes (OLEDs) endow materials with unique luminescent properties, improving device luminescence efficiency and stability.
In addition, in the field of organometallic chemistry, the boric acid compound can react with metal-organic reagents to generate metal-containing organic complexes. Such complexes exhibit unique properties in catalysis, materials science, etc., providing new opportunities for the development of related fields.
In summary, 6-bromo-5-methylpyridine-3-boronic acid has unique uses in many fields such as organic synthesis, drug development, materials science, and organometallic chemistry.

There are several common methods for synthesizing 6-bromo-5-methylpyridine-3-boronic acid.
First, the halogenated pyridine derivative is used as the starting material. 6-bromo-5-methylpyridine-3-halide can be selected to react with metal reagents. For example, it is first reacted with magnesium chips in an inert solvent such as anhydrous ether or tetrahydrofuran to make a Grignard reagent. This process needs to be carried out at low temperature and in an oxygen-free environment. Due to the high activity of Grignard reagents, it is easy to decompose in contact with water and oxygen. After making Grignard reagents, it reacts with borate esters, such as trimethyl borate. After the reaction is completed, 6-bromo-5-methylpyridine-3-boronic acid can be obtained by hydrolysis of dilute acid. The hydrolysis step needs to control the concentration of the acid and the reaction temperature to avoid side reactions of the product.
Second, the palladium-catalyzed cross-coupling reaction strategy can be used. Using 6-bromo-5-methylpyridine-3-halide and organoboron reagents as raw materials, the reaction is carried out under the action of palladium catalyst such as tetra (triphenylphosphine) palladium (0). At the same time, appropriate bases such as potassium carbonate and sodium carbonate need to be added to promote the reaction. Dichloromethane, N, N-dimethylformamide, etc. are commonly used as reaction solvents. This method has good selectivity and high yield, but palladium catalysts are expensive and relatively expensive.
Furthermore, the construction of pyridine rings can also be combined with boration reactions. A pyridine ring containing an appropriate substituent is constructed first, and then a boron group is introduced. Although this method is slightly complicated in steps, it may have unique advantages for the synthesis of target products with specific structures. The reaction process needs to be fine-tuned according to different starting materials and reaction conditions to achieve good synthesis results.

6-Bromo-5-methylpyridine-3-boronic acid is a commonly used reagent in organic synthesis. When storing it, many things need to be paid attention to.
The first to bear the brunt, and the humidity of the storage environment must be strictly controlled. This compound is highly hygroscopic, and once it is damp, it may cause its purity to decrease, which in turn will have an adverse effect on the effect of subsequent reactions. Therefore, it should be stored in a dry place, such as a dryer, and a desiccant can be placed in the dryer to maintain the dryness of the internal environment.
Secondly, temperature is also a key factor. Generally speaking, it should be stored in a low temperature environment, generally 2-8 ° C. If the temperature is too high, it may accelerate its decomposition and deterioration, causing its chemical properties to change and affecting its performance in synthetic reactions.
In addition, it is necessary to pay attention to its isolation from other substances. 6-Bromo-5-methylpyridine-3-boronic acid should avoid contact with oxidants, acids, bases and other substances. Due to the characteristics of its chemical structure, encounters with these substances are very likely to trigger chemical reactions and cause their own failure. When storing, it should be stored separately, away from the above dangerous substances.
In addition, the integrity of the package cannot be ignored. After taking it, be sure to ensure that the package is well resealed to prevent air, moisture, etc. from entering. If the packaging is damaged, the packaging should be replaced in time to ensure the stability of its storage conditions.
Storage of 6-bromo-5-methylpyridine-3-boronic acid requires more attention to humidity, temperature, isolation from other substances and packaging, so as to ensure the quality and performance of the compound, so that it can play its due role in organic synthesis.

I don't know the exact market price range of 6-Bromo-5-methylpyridine-3-boronic acid. The price of this compound often varies due to many factors. First, the purity has a great impact, and the price of high purity is high. If it reaches more than 98% purity, its price must be higher than that of low purity. Second, the purchase quantity is also the key. When purchasing in bulk, the unit price may be reduced due to economies of scale; if purchased in small quantities, the price may be relatively high. Third, the relationship between supply and demand also affects its price. When market demand is strong and supply is tight, the price may rise; if supply exceeds demand, the price may drop. Fourth, different suppliers have different pricing strategies. Well-known and reputable suppliers have strict product quality control, excellent service, and high prices; while some small suppliers offer lower prices for competitive markets.
If you want to know the specific price range, you can go to the chemical trading platform, such as Sinopharm Network, search banner, etc., which often lists the prices of different specifications and purity products. Or contact the chemical supplier to inquire about the required product price. This is an effective way to get its real-time price range.