6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde

6 - Bromo - 4 - methoxypyrazolo [1,5 - a] pyridine - 3 - carbalaldehyde is an organic compound with a wide range of main uses. In the field of organic synthesis, this compound is a key intermediate. Due to its unique structure, it contains bromine atoms, methoxy groups and aldehyde groups, which give it special reactivity.
In the field of pharmaceutical chemistry, this is used as a starting material to construct complex compounds through a series of chemical reactions, aiming to find lead compounds with biological activity, or to optimize the structure of existing drugs to improve efficacy and reduce side effects. For example, aldehyde groups can participate in condensation reactions and react with compounds containing amino groups to form Schiff bases. This structure is commonly found in many molecules with pharmacological activity.
In the field of materials science, this compound may be used to prepare functional materials. By modifying and assembling its structure, the material can be endowed with special optical and electrical properties. For example, bromine atoms can participate in subsequent halogenation reactions, introducing other functional groups, and then regulating the properties of the material.
At the level of scientific research and exploration, as a research object, it helps scientists to deeply explore the reaction mechanism and properties of heterocyclic compounds. Through the study of its reaction conditions and product structure, it can expand the knowledge boundary of organic chemistry and provide reference for the development of new synthesis methods.
In short, 6-Bromo-4-methoxypyrazolo [1,5-a] pyridine-3-carbalaldehyde has important uses in many fields such as organic synthesis, drug development, materials science and scientific research due to its unique structure, providing key support and opportunities for the development of various fields.

The synthesis of 6-bromo-4-methoxypyrazolo [1,5-a] pyridine-3-formaldehyde involves a variety of approaches. First, it can be started from a suitable pyridine derivative. First, the pyridine ring is brominated in a suitable brominating reagent, such as N-bromosuccinimide (NBS), in a suitable solvent, such as dichloromethane, under mild reaction conditions, so that the bromine atom is precisely introduced into the target position to form a bromine-containing pyridine intermediate.
Then, through the methoxylation step. A strong base such as sodium methoxide is selected to react with a halogenated pyridine intermediate in a methanol solvent to achieve methoxy substitution to obtain a pyridine derivative containing bromine and methoxy.
Subsequently, the structure of pyrazolo [1,5-a] pyridine is constructed. Nitrogen-containing heterocyclic synthesis reagents can be used to react with the aforementioned derivatives under acid or base catalysis to form a pyrazolo [1,5-a] pyridine skeleton through cyclization.
As for the introduction of aldehyde groups, the Vilsmeier-Haack reaction can be used. The active complex formed by N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl) interacts with the obtained pyrazolo [1,5-a] pyridine derivatives to introduce aldehyde groups at specific positions in the pyridine ring to obtain 6-bromo-4-methoxypyrazolo [1,5-a] pyridine-3-formaldehyde.
Another method can also start from pyrazole derivatives and gradually construct the target molecular structure through similar bromination, methoxylation and aldehyde-ylation steps. Fine regulation of reaction conditions, such as temperature, reaction time, and reagent dosage, is crucial to the purity and yield of the product, and researchers need to explore and optimize it in detail.

6-Bromo-4-methoxypyrazolo [1,5-a] pyridine-3-formaldehyde, this is an organic compound. Looking at its structure, bromine atoms, methoxy groups and aldehyde groups all have unique chemical activities, endowing this compound with diverse physical and chemical properties.
First of all, its solubility is mentioned. Due to the hydrophilic group containing methoxy, and the hydrophobic structure of pyridine and pyrazolo rings, it should have a certain solubility in organic solvents such as dichloromethane and N, N-dimethylformamide, but the solubility in water may be limited.
When it comes to the melting boiling point, the intermolecular due to aldehyde groups can form hydrogen bonds, resulting in enhanced intermolecular forces, and the boiling point is expected to be quite high; and the relative mass of atoms in the structure is relatively large, especially bromine atoms, which increases the intermolecular forces, so the melting point will not be low.
In terms of stability, the pyridine ring and the pyrazole ring form a conjugated system, which gives a certain stability. However, aldehyde groups are chemically active and are easily oxidized to carboxylic acids. In case of strong oxidants, this oxidation reaction is more likely to occur; bromine atoms can participate in nucleophilic substitution reactions. Under appropriate nucleophilic reagents and reaction conditions, bromine atoms can be replaced, causing molecular structure changes.
Spectral properties, in the infrared spectrum, the C = O bond of the aldehyde group will show a strong absorption peak at about 1700 cm. The C-O bond of the methoxy group has an absorption peak at about 1200-1300 cm. In the hydrogen nuclear magnetic resonance spectrum, the aldehyde hydrogen has a characteristic peak at the low field, and the methoxy hydrogen and the hydrogen on the ring show peaks at the corresponding chemical shifts according to their chemical environments. In short, the physicochemical properties of this compound are determined by its unique structure, which is extremely important for its research and application.

The chemical stability of 6-bromo-4-methoxypyrazolo [1,5-a] pyridine-3-formaldehyde needs to be investigated in detail. In ordinary chemical situations, bromine atoms in this compound are quite active, and because of their high electronegativity, they are prone to participate in many nucleophilic substitution reactions. When encountering nucleophilic reagents, bromine atoms may be replaced, causing molecular structure changes.
Furthermore, although methoxy groups are relatively stable, they may also participate in the reaction under severe conditions such as specific strong acids, strong bases or high temperatures. For example, in a strongly acidic environment, the oxygen atom or protonation of the methoxy group affects the electron cloud distribution and reactivity of the whole molecule.
The aldehyde group is an extremely active functional group. It is prone to oxidation reactions, and can be oxidized to carboxyl groups when encountering common oxidants, such as Torun reagent and Feilin reagent. It can also participate in reduction reactions to obtain alcohol products. And aldehyde groups can condensate with compounds containing active hydrogen, such as alcohols, amines, etc., to form derivatives such as hemiacetals, acetals, or Schiff bases.
In summary, the chemical properties of 6-bromo-4-methoxypyrazolo [1,5-a] pyridine-3-formaldehyde are not very stable. Under different chemical environments and reaction conditions, various functional groups in the molecule can participate in various chemical reactions, resulting in changes in their structure and properties.

I look at the market price of "6 - Bromo - 4 - methoxypyrazolo [1,5 - a] pyridine - 3 - carbalaldehyde" you are inquiring about. This is a specific compound in the field of fine chemicals. However, it is not easy to know its exact market price. Cover because its price is often affected by many factors.
First, the cost of production. The price of raw materials, the simplicity of the synthesis process, and the amount of energy consumption are all related to cost. If raw materials are scarce and expensive, or if synthesis requires complicated steps and harsh conditions, the cost will be high, and its price will also rise.
Second, the supply and demand of the market. If many industries such as pharmaceutical research and development, material science, etc. have strong demand for it, but the supply is limited, the price will rise; conversely, if the demand is low and the supply is sufficient, the price may decline.
Third, the difference between manufacturers and brands. Different manufacturers have different production processes and product purity, and well-known brands may have different pricing due to quality control and good reputation.
In the era of "Tiangong Kaiwu", although there were no such fine chemicals, it talked about all kinds of process products, and also talked about the impact of cost, supply and demand on price. The same is true for today's "6-Bromo-4-methoxypyrazolo [1,5-a] pyridine-3-carbalaldehyde". To obtain accurate market prices, it is recommended to consult chemical product suppliers, browse professional chemical trading platforms, or consult industry veterans to obtain more accurate price information.