6-BROMO-3-PYRIDINECARBOXALDEHYDE

6-Bromo-3-pyridyl formaldehyde, which has a wide range of uses. In the field of organic synthesis, it is often a key intermediate. It can interact with many reagents through a specific reaction path to derive organic compounds with complex structures and different functions.
For example, in the field of medicinal chemistry, its role should not be underestimated. By reacting with nucleophiles such as nitrogen and oxygen, pyridine derivatives with biological activity are constructed, laying the foundation for the creation of new drugs. Due to the unique structure of pyridine rings and aldehyde groups, the synthesized compounds have potential pharmacological activities, such as antibacterial, anti-inflammatory, and anti-tumor. < Br >
In the field of materials science, 6-bromo-3-pyridyl formaldehyde is also useful. It can participate in the synthesis of polymer materials, and connect to the main chain or side chain of the polymer through chemical reactions to change the physical and chemical properties of the material, such as improving the stability and optical properties of the material.
In addition, in the preparation of fine chemicals, it is an important starting material for the synthesis of fine chemicals such as special fragrances and dyes. After a series of organic conversions, it gives unique properties and application value to fine chemical products. In conclusion, 6-bromo-3-pyridine formaldehyde has shown important uses in many fields due to its unique chemical structure, promoting technological innovation and Product Research & Development in various fields.

The synthesis method of 6-bromo-3-pyridyl formaldehyde is a very important topic in the field of organic synthesis. To make this substance, there are several common paths.
First, 3-pyridyl formaldehyde is used as the starting material to introduce bromine atoms by halogenation reaction. In this process, appropriate brominating reagents can be selected, such as bromine (Br ²), N-bromosuccinimide (NBS), etc. If bromine is used, a suitable reaction solvent, such as dichloromethane, carbon tetrachloride, etc., should be selected, and the reaction should be carried out under the catalysis of appropriate catalysts (such as iron powder, iron tribromide, etc.) under low temperature or normal temperature conditions. Due to the electron cloud distribution characteristics on the pyridine ring, the bromine atom is more likely to be substituted at the 6-position with low steric resistance and relatively high electron cloud density, so as to obtain the target product 6-bromo-3-pyridine formaldehyde.
Second, the aldehyde group and bromine atom can be constructed by multi-step reaction from the pyridine derivative. For example, first, a suitable pyridine derivative is used as the substrate, and a functional group that can be converted into an aldehyde group, such as cyano (-CN), is introduced at the 3-position of the pyridine ring through reactions such as nucleophilic substitution. After that, the cyano group is converted into an aldehyde group by hydrolysis reaction. At the same time, at a suitable stage, bromine atoms are introduced through halogenation at the 6-position of the pyridine ring. Although this path is slightly complicated, it can be flexibly adjusted according to the feasibility of specific starting materials and reaction conditions to achieve higher yield and selectivity.
Third, the coupling reaction catalyzed by transition metals. 6-Bromo-3-pyridinal formaldehyde is directly synthesized by coupling reaction of bromine-containing pyridine derivatives and aldehyde-containing reagents under the action of transition metal catalysts (such as palladium catalysts, such as tetra (triphenylphosphine) palladium, etc.). This method has mild conditions and high selectivity. However, it is necessary to pay attention to the influence of factors such as the amount of catalyst, the choice of ligand and the pH of the reaction system on the reaction. Different synthesis methods have their own advantages and disadvantages. In actual operation, when considering the availability of raw materials, cost, difficulty of reaction conditions and many other factors, make a prudent choice.

6-Bromo-3-pyridyl formaldehyde, this is an organic compound. Its physical properties are quite characteristic and it is widely used in many fields.
Looking at its properties, under normal temperature and pressure, 6-bromo-3-pyridyl formaldehyde is mostly in the state of light yellow to yellow crystalline powder, which is easy to observe and use.
As for the melting point, it is about 63-67 ° C. The characteristic of melting point has a profound impact on its state transition at different temperatures. When the temperature is lower than the melting point, the substance stabilizes into a solid state; once the temperature rises to the melting point and above, it gradually melts into a liquid state. This process is of great significance in many chemical operations and experiments.
Solubility is also one of the key physical properties. 6-Bromo-3-pyridyl formaldehyde exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This property makes it possible to create a suitable reaction environment with these organic solvents in organic synthesis reactions and promote the smooth progress of the reaction. However, its solubility in water is poor. This difference can be exploited in the separation and purification steps of substances, and effective separation from other impurities can be achieved by selecting an appropriate solvent.
Its smell is weak and special. Although it is not strong and pungent, it is unique. Skilled chemists can use this to initially identify the substance.
In addition, 6-bromo-3-pyridine formaldehyde is sensitive to air and humidity. Exposure to air for a long time may cause quality changes due to reactions such as oxidation; in high humidity environments, moisture absorption and other phenomena may also occur, affecting its chemical properties and purity. Therefore, it needs to be stored in a dry, cool and well-sealed place to properly maintain the stability of its physical and chemical properties.
All kinds of physical properties lay the foundation for the application of 6-bromo-3-pyridine formaldehyde in organic synthesis, drug development and other fields. Due to its unique physical properties, it can meet the needs of various complex reactions and application scenarios.

I look at your question, but I am inquiring about the market price of 6-bromo-3-pyridyl formaldehyde. However, this price often varies according to time, place, quality and supply and demand conditions, and it is difficult to determine.
In the past, the price of chemical products relied on the exchange and bargaining between merchants. In today's world, the market is easy and complicated, and the information flow is quite smooth. The price of chemical products is also influenced by many parties.
If it is in the market of ordinary chemical raw materials, the price may vary according to the size of the batch. If the batch is small, the price may be slightly higher; the larger the batch, the price per unit may be slightly reduced. < Br >
And the price of this compound is also related to the difficulty of production and the cost of raw materials. If the production process is difficult, or the required raw materials are scarce and expensive, the market price will also be high.
Also, the price varies depending on the region. In places where the chemical industry is concentrated, the supply is sufficient, and the price may be slightly flat; in remote places, the transportation cost increases, and the price may be higher.
Furthermore, the state of market supply and demand is the key to the price. If there are many people who want it, but there are few people who supply it, the price will rise; on the contrary, if the supply exceeds the demand, the price may fall.
Overall, in order to determine the current market price of 6-bromo-3-pyridyl formaldehyde, it is necessary to consult chemical raw material suppliers, trading platforms, or detailed market transaction data to obtain a more accurate price.

6-Bromo-3-pyridyl formaldehyde is an organic compound, and special attention should be paid to the following items when storing and transporting:
One is the storage temperature. This compound should be stored in a cool place, because high temperature can easily cause its chemical properties to change, or cause decomposition. Generally speaking, storing it in a refrigerated environment of 2-8 ° C can better maintain its stability and prevent deterioration, just like ancient people's storage, and also choose a cool and dry place to protect its quality.
The second is about packaging. It must be sealed and packaged to isolate air and moisture. 6-Bromo-3-pyridyl formaldehyde is easy to react with oxygen and moisture in the air. Such reactions can be avoided if the sealed packaging is hard and clear. It is commonly sealed in glass or plastic bottles, and the bottle should be kept dry without excess water vapor.
The third is to avoid light. This compound is quite sensitive to light, and light will accelerate its chemical reaction and cause it to deteriorate. Therefore, it should be stored in a dark container or in a dark place. Just like the things cherished by the ancients, it is often hidden in the dark of the cabinet, free from light disturbance.
The fourth is about transportation. Be sure to ensure that the packaging is intact during transportation to prevent leakage. Due to its certain chemical activity, it may react with surrounding substances after leakage or cause pollution to the environment. The means of transportation also need to maintain suitable temperature and humidity conditions to avoid violent vibration, just like escorting precious utensils, handle it with care, and do not disturb it.
Fifth, pay attention to isolation from other substances. Do not co-store and transport with oxidants, acids, bases, etc., because 6-bromo-3-pyridine formaldehyde is prone to chemical reactions with these substances, causing danger, just like things with different properties, do not mix, so as not to change.