6-Bromo-3-methylpyridine-2-amine

6-Bromo-3-methylpyridine-2-amine, an organic compound, has important uses in many fields.
First, in the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of drug molecules with specific biological activities. For example, by chemically modifying its pyridine ring and substituents, compounds that exhibit high affinity and selectivity for specific disease targets can be constructed. Medical research has found that some compounds containing pyridine amines have inhibitory effects on the growth of some tumor cells, and 6-bromo-3-methyl pyridine-2-amine may provide novel starting materials and structural templates for the development of anti-cancer drugs.
Second, in the field of materials science, it can be used to prepare functional materials. The presence of pyridine rings and amine groups endows the compound with unique electronic properties and coordination ability, and can form stable complexes with metal ions, which can be used to prepare materials with special optical and electrical properties, such as luminescent materials, conductive polymers, etc. For example, in the development of organic electroluminescent light emitting diode (OLED) materials, such compounds may become key components to improve the luminous efficiency and stability of devices after appropriate modification.
Third, in the field of pesticide chemistry, 6-bromo-3-methylpyridine-2-amine also has potential application value. It can be used as an important raw material for the synthesis of new pesticides. By introducing different substituents to regulate their biological activities, pesticide products with efficient control effect on specific pests or bacteria and environmentally friendly can be developed, providing new solutions for pest control in agricultural production.

The synthesis of 6-bromo-3-methylpyridine-2-amine is an important topic in the field of organic synthesis. According to past literature, there are probably several ways to synthesize it.
One method can also be started from an appropriate pyridine derivative. Introduce methyl at a specific position before the pyridine ring, which can be achieved by alkylation reaction. Commonly used alkylation reagents, such as halomethane, can successfully methylate the pyridine ring under suitable bases and reaction conditions. Then, bromine atoms are introduced at a specific check point. In this step, brominating reagents, such as N-bromosuccinimide (NBS), are often used to achieve selective substitution of bromine atoms under the action of light or initiators, and then Pyridine derivatives containing bromine and methyl are obtained. Finally, after amination, the halogen atom or other substituted groups of the pyridine ring ortho-position are replaced with amine groups. Commonly used amination reagents, such as ammonia derivatives, etc., can be synthesized with the help of metal catalysts or specific reaction conditions to achieve the synthesis of 6-bromo-3-methylpyridine-2-amine.
The second method also uses other heterocyclic compounds as starting materials and is converted through a multi-step reaction. First, the heterocyclic compound is converted through a series of reactions, such as ring opening, rearrangement, etc., to construct the basic skeleton of the pyridine ring. At the same time, methyl and bromide atoms are introduced in appropriate steps, and finally modified by amination. The target product 6-bromo-3-methyl pyridine-2-amine is successfully prepared. These methods have their own advantages and disadvantages. The reaction conditions, yield and selectivity need to be carefully considered before the most suitable synthetic path can be selected.

6-Bromo-3-methylpyridine-2-amine is one of the organic compounds. It has many physical properties, which are described as follows:
Looking at its properties, it mostly shows a white-like to light yellow crystalline powder under normal conditions, which is easy to observe and handle.
When it comes to the melting point, it is about 142-146 ° C. The melting point is an important physical property of the substance. At this temperature, 6-bromo-3-methylpyridine-2-amine melts from a solid state to a liquid state. This property is of great significance for the identification and purity judgment of compounds. If the melting point of the sample is consistent with the literature values and the melting range is narrow, it indicates that the purity is quite high; conversely, if the melting range is wide or the melting point is deviated, it may contain impurities.
In terms of solubility, 6-bromo-3-methylpyridine-2-amine is slightly soluble in water. Water is a common solvent, and its solubility in water is poor. In the molecular structure of this compound, although there are amino groups that can form hydrogen bonds with water, the presence of bromine atoms and methyl groups increases the hydrophobicity of the molecule, making it insoluble in water. However, it is soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. In dichloromethane, it can be well dissolved by virtue of the principle of similar miscibility between halogenated hydrocarbons and compounds; in DMF, due to the strong polarity of DMF, it can form intermolecular forces with compounds to promote dissolution. This solubility characteristic is widely used in organic synthesis, separation and purification.
As for the boiling point, under specific pressure conditions, it can reach a certain value. The boiling point is affected by external pressure, usually the pressure decreases, and the boiling point also decreases. Knowing the boiling point helps to separate and purify it by means of distillation and other means.
In addition, 6-bromo-3-methylpyridine-2-amine has certain stability, but under specific conditions, such as high temperature, strong acid, strong base environment, or chemical reaction, resulting in structural changes. Because its molecules contain bromine atoms, amino groups and pyridine rings, these functional groups endow compounds with unique chemical activities and provide diverse reaction check points for organic synthesis.

6-Bromo-3-methylpyridine-2-amine, this is an organic compound with many unique chemical properties.
It is basic because of its amino group. The nitrogen atom in the amino group has lone pairs of electrons, which can accept protons and can form salts in acidic solutions. For example, in the case of strong acids, the amino nitrogen atom will combine with the proton to form a positively charged ion, exhibiting its basic characteristics.
6-bromo-3-methylpyridine-2-amine is also nucleophilic. The lone pair of electrons of the amino group makes it a nucleophilic reagent and participates in nucleophilic substitution reactions. For example, when encountering halogenated hydrocarbons, the amino group will attack the carbon atom of the halogenated hydrocarbon, and the halogen atom will leave to form a new compound, which is an important way to build a carbon-nitrogen bond.
The bromine atom in this compound is electrophilic and can participate in the electrophilic substitution reaction. Due to the large electronegativity of the bromine atom, when connected to the pyridine ring, the electron cloud density distribution of the pyridine ring changes. Under suitable conditions, other nucleophiles can attack the location of the bromine atom and cause a substitution reaction.
In addition, 6-bromo-3-methylpyridine-2-amine can participate in many organic synthesis reactions because it contains a variety of active functional groups, which can be used to construct more complex organic molecular structures. It has potential applications in pharmaceutical chemistry, materials science and other fields. For example, it can be modified into a drug molecule with specific biological activities through a series of reactions, or as a structural unit of functional materials, giving the material unique properties.

6-Bromo-3-methylpyridine-2-amine is in the market, and its price range is difficult to determine. The price of the cap often varies due to many reasons, such as the manufacturer, quantity, quality, and supply and demand in the market.
In the past, in the market of chemical products, the price of similar products often varied due to the simplicity of the process and the wide and narrow sources of materials. If the process is easy and the materials are easy to obtain, the price may be flat; conversely, if the process is complex and the materials are thin, the price will be high.
In today's market, when the amount of 6-bromo-3-methylpyridine-2-amine is small and the buyer is thin, the price per gram may be tens of yuan; if the quantity is large and the supply and demand are strong, if purchased in bulk, the price per gram may be reduced to a few yuan. However, this is only an approximate estimate, and the actual price must be subject to the current market conditions. Producers are different, and their prices are also different. Products from famous factories may be expensive because of their high quality; new factories may be close to the people because of market competition.
In addition, the chemical market has been volatile recently, and the price of raw materials and transportation costs are all factors. If the price of raw materials increases, the price of 6-bromo-3-methylpyridine-2-amine will also increase; if the transportation cost increases, the price sold in the distant place will also be affected by it. Therefore, to determine the price, we must carefully consider the current situation and consult various merchants to obtain a close and accurate number.