6-Bromo-3-iodo-2-methylpyridine

6-Bromo-3-iodine-2-methylpyridine is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in the field of pharmaceutical chemistry, it can be used as a building block for biologically active molecules. Due to the structural characteristics of pyridine rings, it can interact with specific targets in organisms. The introduction of bromine and iodine atoms can modify the physical and chemical properties of molecules, such as lipophilicity, electron cloud distribution, etc., and then affect their biological activity. For example, it can be used to create new antimicrobial drugs. By combining pyridine and its substituents with specific enzymes or proteins of bacteria, it can inhibit the growth and reproduction of bacteria.
Second, in the field of materials science, it can participate in the preparation of functional materials. Because it contains halogen atoms, it can affect the electrical and optical properties of materials. For example, in the preparation of organic optoelectronic materials, it can be introduced into the polymer skeleton, or it can adjust the energy level structure of the material and improve the charge transport performance. It is expected to be applied to organic Light Emitting Diode (OLED), organic solar cells and other devices to improve their photoelectric conversion efficiency and stability.
Third, it also has potential value in the field of pesticide chemistry. It can be rationally designed and modified to create high-efficiency and low-toxicity pesticides. The combination of pyridine ring and halogen atoms may have specific effects on the nervous system and respiratory system of pests, achieving the purpose of pest control, and the impact on the environment is relatively small.
In summary, 6-bromo-3-iodine-2-methyl pyridine has shown important uses in many fields such as organic synthesis, medicine, materials, pesticides, etc., providing a key chemical basis for the development of related fields.

To prepare 6-bromo-3-iodine-2-methylpyridine, there are two common methods.
First, 2-methylpyridine is used as the starting material. Shilling 2-methylpyridine reacts with bromine under appropriate reaction conditions, such as in a suitable solvent and catalyzed by an appropriate catalyst, so that the bromine atom replaces the hydrogen atom at a specific position on the pyridine ring to obtain 6-bromo-2-methylpyridine. Afterwards, the obtained product is reacted with an iodine source, such as iodine elemental substance and an appropriate oxidant, and in a suitable reaction system, the iodine atom replaces the hydrogen atom at the corresponding position on the pyridine ring to obtain 6-bromo-3-iodine-2-methyl pyridine. In this approach, the control of the reaction conditions at each step is very critical, such as the reaction temperature, reaction time, and the proportion of reactants, which all affect the yield and selectivity of the reaction.
Second, other suitable compounds containing pyridine structures can be selected as starting materials. For example, a specific substituted pyridine derivative is prepared first, and some of the substituents required for the target product are already present in its structure, and then bromine and iodine atoms are gradually introduced through a series of reaction steps. Iodine atoms can be introduced first, followed by bromine atoms, or vice versa. The specific order depends on factors such as the structure of the starting material, the feasibility of the reaction conditions, and the selectivity of the reaction. During each reaction step, the reaction process needs to be monitored to adjust the reaction conditions in time to ensure that the reaction proceeds in the direction of generating the target product. And attention should be paid to the side reactions that may occur during the reaction process, and measures should be taken to suppress the occurrence of side reactions as much as possible to improve the purity and yield of the target product.

6-Bromo-3-iodine-2-methylpyridine is a kind of organic compound. Its physical properties are particularly important, and it is related to the properties of this compound in various chemical processes and practical applications.
First of all, on its appearance, under normal conditions, 6-bromo-3-iodine-2-methylpyridine is mostly in a solid state, or a powder, or a crystalline state. Its color is either colorless and transparent, or yellowish. The color varies depending on the purity and preparation method.
As for the melting point, the melting point of this compound is also fixed. It is difficult to obtain the exact experimental data, but it can be inferred that its melting point is closely related to the intermolecular forces. The van der Waals forces and hydrogen bonds between molecules cause the molecules to be arranged in an orderly manner, and a specific energy is required to cause their lattice to disintegrate, from solid to liquid. Generally speaking, the melting point of organic compounds is quite wide, 6-bromo-3-iodine-2-methylpyridine or within a certain range, which is determined by its molecular structure.
Boiling point, the temperature when the compound changes from liquid to gaseous state. The boiling point of 6-bromo-3-iodine-2-methylpyridine is also affected by the intermolecular forces. Because the molecule contains halogen atoms such as bromine and iodine, the molecular weight is large, and the intermolecular force is enhanced, so the boiling point may be higher. To make it boil, more energy is required to overcome the attractive force between molecules.
Solubility is also an important physical property. In organic solvents, such as common ethanol, ether, dichloromethane, etc., 6-bromo-3-iodine-2-methyl pyridine may have a certain solubility. Due to the "similar miscibility" principle, organic compounds are mostly soluble in organic solvents. However, in water, because its polarity is different from that of water molecules, and it contains hydrophobic methyl groups and other groups, its solubility may be poor.
In addition, density is also one of the physical properties. The density of 6-bromo-3-iodine-2-methylpyridine is due to the large atomic weight of bromine and iodine atoms, or greater than that of common organic solvents. Its density is smaller than that of separation, purification and other operations.
In summary, the physical properties of 6-bromo-3-iodine-2-methylpyridine, such as appearance, melting point, boiling point, solubility and density, are determined by its molecular structure, and are indispensable factors in chemical research and practical applications.

6-Bromo-3-iodine-2-methylpyridine is one of the organic compounds. Its chemical properties are particularly important and it is widely used in the field of organic synthesis.
The first part of its substitution reaction. Because both bromine and iodine in this compound are halogen atoms, they have equivalent activities. Bromine and iodine atoms can be replaced by various nucleophiles. If alkoxides are used as nucleophiles, under appropriate reaction conditions, bromine or iodine atoms can be replaced by alkoxy groups to form corresponding ether compounds. The key to this reaction lies in the reaction temperature, the choice of solvent and the amount of base. The appropriate temperature can promote the smooth progress of the reaction. If the temperature is too high, side reactions may occur; and the appropriate solvent can dissolve the reactants and promote the mass transfer of the reaction. The role of the base is to activate the nucleophilic reagent and enhance its ability to attack halogen atoms.
Furthermore, its metallization reaction cannot be ignored. 6-Bromo-3-iodine-2-methyl pyridine can react with metal reagents, such as lithium reagents. Lithium atoms can replace bromine or iodine atoms to form organolithium compounds. This organolithium compound is extremely active and can react as a nucleophile with many electrophilic reagents, such as aldose and ketone, to form carbon-carbon bonds, providing an effective way for the synthesis of complex organic molecules. This reaction needs to be carried out at a low temperature and in an anhydrous and oxygen-free environment to ensure the stability of organolithium compounds.
In addition, the pyridine ring of this compound also has unique chemical properties. The nitrogen atom of the pyridine ring has lone pair electrons, which can coordinate with protons or other Lewis acids. This property allows 6-bromo-3-iodine-2-methylpyridine to act as a ligand in some catalytic reactions to form complexes with metal catalysts, which in turn affects the activity and selectivity of catalysts. At the same time, the electron cloud distribution of the pyridine ring is affected by bromine, iodine and methyl, which makes the reactivity of different positions on the pyridine ring different. In electrophilic substitution reactions, specific positions can be replaced according to this property, providing the possibility for precise control of organic synthesis. The chemical properties of 6-bromo-3-iodine-2-methylpyridine are rich and diverse, and it plays an important role in organic synthesis chemistry, providing many effective strategies and methods for the construction of organic compounds.

6-Bromo-3-iodine-2-methylpyridine is on the market, and its price range is difficult to determine. The price of this compound is often influenced by many factors.
The first to bear the brunt is its purity. If the purity is extremely high, it is almost flawless, and it is suitable for high-end scientific research or special industrial processes, its price will be high. On the contrary, the purity is slightly lower, and it is only for general experimental purposes, and the price should be low.
Furthermore, the difficulty of preparation also affects the price. The synthesis of this compound may require complicated steps, the raw materials are rare and difficult to obtain, or the reaction conditions are harsh and need to be carefully controlled, the production cost will increase greatly, and the price will also rise.
The state of market supply and demand is also the key. If there is a surge in demand for a while and the supply is limited, the merchant will raise the price; if the demand is low and the supply is full, the price may drop in order to destock.
In addition, the difference between suppliers also makes the price different. Well-known large factories have strict quality control, stable products, and high prices; emerging small factories may attract customers at low prices in order to compete for the market.
Overall, in the world of "Tiangong Kaiwu", although there is no exact comparable example of this compound, its price may fluctuate between a few and several hundred yuan per gram, depending on the above factors.