6-Bromo-3-hydroxy-5-iodopyridine

6 - Bromo - 3 - hydroxy - 5 - iodopyridine is an organic compound with unique chemical properties. In its structure, bromine (Br), iodine (I) and hydroxyl (-OH) coexist in the pyridine ring, which endows the compound with various chemical activities.
First of all, the hydroxyl group is nucleophilic and easily participates in the substitution reaction. When encountering electrophilic reagents, the hydroxyl oxygen atom will attack with its lone pair electrons to form a new covalent bond, or dehydrate under appropriate conditions to form a double bond structure.
The electron cloud density distribution of the pyridine ring changes due to the strong electronegativity of bromine and iodine atoms. In the nucleophilic substitution reaction, bromine and iodine atoms can be used as leaving groups, which can be replaced by other nucleophilic reagents to form new derivatives. Due to the large radius of iodine atoms and the relatively small bond energy of C-I bonds, iodine atoms are more likely to leave, and the reactivity is slightly higher than that of bromine atoms.
In addition, the pyridine ring itself is aromatic and can undergo electrophilic substitution reaction. Because bromine and iodine are electron-withdrawing groups, the electron cloud density of the pyridine ring will decrease, and the electrophilic substitution reaction activity is lower than that of the benzene ring, and the substitution reaction mainly occurs at the position where the electron cloud density is relatively high.
At the same time, the compound can participate in a variety of metal-catalyzed reactions, such as palladium-catalyzed coupling reactions, to construct complex organic molecular structures, and is widely used in the field of organic synthesis. Its chemical properties provide many possibilities for organic synthetic chemistry research and new drug development, and can be used as a key intermediate to create compounds with specific biological activities or material properties.

To prepare 6-bromo-3-hydroxy-5-iodopyridine, there are many methods, and the common ones are as follows.
First, pyridine is used as the starting material. First, pyridine is brominated. Under appropriate conditions, bromine atoms can be introduced at specific positions in the pyridine ring by using brominating reagents, such as liquid bromine, in suitable catalysts (such as iron powder, etc.). After that, the obtained bromine-containing pyridine derivatives can be introduced into hydroxyl groups by means of nucleophilic substitution. Finally, the iodization reaction is carried out, and a suitable iodization reagent is selected, such as iodine in combination with an appropriate oxidant, to achieve the introduction of iodine atoms at the target position, so as to obtain 6-bromo-3-hydroxy-5-iodine pyridine.
Second, we can start from other suitable pyridine derivatives. For example, first prepare pyridine derivatives with bromine, hydroxy, and iodine groups that can be converted into bromine, hydroxy, and iodine groups, such as pyridine compounds containing halogen atoms, hydroxyl precursors, etc. Then, through a series of reactions such as substitution, oxidation, and reduction, each group is gradually converted into the target bromine, hydroxy, and iodine atoms. This process requires fine control of the reaction conditions to ensure the selectivity and yield of each step of the
Third, the coupling reaction strategy catalyzed by transition metals is used. Pyridine derivatives containing one or two of bromine, hydroxyl and iodine are selected, and the remaining required groups are introduced through the coupling reaction catalyzed by transition metal catalysts such as palladium and copper. This method requires precise selection of catalysts, ligands and reaction solvents to optimize the reaction effect and achieve effective synthesis of 6-bromo-3-hydroxy-5-iodine.

6-Bromo-3-hydroxy-5-iodopyridine, which is useful in many fields such as medicine and materials.
In the field of medicine, it is an important organic synthesis intermediate. Compounds with specific biological activities can be prepared through a series of chemical reactions. For example, when developing new antibacterial drugs, this is used as the starting material and ingeniously chemically modified to construct structures that fit the key targets of bacteria, interfere with the normal physiological activities of bacteria, and thus exert antibacterial effect. Another example is in the development of anti-tumor drugs, using it as the basis to build a molecular framework, introduce different functional groups, and regulate the interaction between drugs and tumor cell targets, which is expected to obtain high-efficiency and low-toxicity anti-cancer drugs.
In the field of materials, 6-bromo-3-hydroxy-5-iodopyridine also has unique value. In organic optoelectronic materials, it can be introduced into polymers or small molecule systems as a structural unit. Due to its special electronic structure and spatial configuration, it can adjust the photoelectric properties of the material, such as changing the luminous wavelength of the material and improving the charge transfer efficiency. When preparing organic Light Emitting Diodes (OLEDs), the materials containing this structure can optimize the luminous performance of the device and achieve better display effect. In addition, in sensor materials, using their selective interactions with specific substances, sensors with high sensitivity and selectivity to certain ions or molecules can be designed for environmental monitoring, biological detection, and the like.

6 - Bromo - 3 - hydroxy - 5 - iodopyridine is an organic compound with important uses in chemical industry, pharmaceutical research and development and other fields. Its market price often fluctuates due to a variety of factors.
The first to bear the brunt, the purity has a significant impact on the price. 6 - Bromo - 3 - hydroxy - 5 - iodopyridine of high purity is expensive because it is difficult to prepare and requires more delicate and complex purification processes. If used in pharmaceutical research and development, the impurity content requirements are strict, and the purity is more than 99%. The price may be several thousand yuan per gram. The purity is slightly lower, such as about 95%. Although it can meet some chemical production needs, the price may drop to several hundred yuan per gram.
Furthermore, the market supply and demand relationship also affects its price. If a certain period of pharmaceutical companies' enthusiasm for the research and development of new drugs containing this compound increases sharply, and the supplier's production capacity is limited, the supply is in short supply, and the price is bound to rise. On the contrary, if the market demand is weak and the supply is sufficient, the price will stabilize or decline.
In addition, production costs are also key. The price of raw materials and the complexity of the preparation process will affect the final cost. If the starting materials for preparing the compound are scarce or the price rises, the production cost will increase, and the selling price will also increase accordingly. Complex synthesis processes require special reaction conditions, expensive catalysts or multi-step reactions, which will undoubtedly increase costs and push up prices.
Due to the complexity and variability of the above factors, the market price of 6-Bromo-3-hydroxy-5-iodopyridine is difficult to generalize. It is necessary to monitor market dynamics in real time and communicate closely with suppliers to grasp accurate price information.

6-Bromo-3-hydroxy-5-iodopyridine is also an organic compound. If you want to keep this thing well, you should pay attention to all kinds of storage.
Bear the brunt of it, and it should be placed in a cool place. Cover a cool place to slow down its reaction due to heat. If exposed to high temperature, the molecular movement will intensify, or its structure will mutate, which will damage its inherent nature. It is quite important to choose a cool place to keep the temperature constant in a lower area.
Second, it is necessary to keep it dry. Water vapor is also a medium for many chemical reactions. If 6-bromo-3-hydroxy-5-iodopyridine encounters water vapor or hydrolysis, its purity and quality will be damaged. Therefore, the storage place should be protected from moisture and can be supplemented by desiccant to absorb the surrounding water vapor to protect its quality.
Furthermore, sealing is also a priority. The purpose of sealing is to prevent it from contacting gases such as oxygen and carbon dioxide in the air. Oxygen can cause it to oxidize, and carbon dioxide or salt with it can change its chemical properties. Second, it can prevent external impurities from mixing and keep it pure.
In addition, the storage place should also be kept away from fire sources and oxidants. Although 6-bromo-3-hydroxy-5-iodopyridine is not flammable and frying, it may be exposed to fire or oxidants, or react violently, endangering safety.
In short, 6-bromo-3-hydroxy-5-iodopyridine needs to be stored in a cool, dry, sealed place, and away from fire and oxidants to maintain its purity and stability for a long time.