6-bromo-3-fluoro-pyridine-2-carbaldehyde

6-Bromo-3-fluoropyridine-2-formaldehyde, this substance has a wide range of uses and is a key intermediate in the field of medicinal chemistry.
When medicine is created, it is often used as a basis to build novel structures. Many drugs containing pyridine rings are used to build the core framework, and then modified to obtain compounds with specific activities and targeting, or used for anti-cancer, which can accurately inhibit the proliferation and metastasis of cancer cells; or used for anti-infection, which can effectively kill bacteria and viruses.
In the field of materials science, it also has extraordinary performance. Due to its unique chemical structure, it can participate in the synthesis of functional materials. After ingenious design, it is integrated into a polymer, giving the material fluorescence properties, such as optical sensors, Light Emitting Diode and other devices, with excellent luminescence performance, which is expected to optimize the performance of such devices.
Furthermore, in the field of organic synthetic chemistry, as a reaction substrate, it can use a variety of chemical reactions, such as nucleophilic substitution, condensation, etc., to expand the molecular structure and construct complex organic compounds, providing organic synthetic chemists with the possibility to explore novel reaction paths and compounds, greatly promoting the development of organic synthetic chemistry.

To prepare 6-bromo-3-fluoro-pyridine-2-formaldehyde, there are several common methods.
First, the compound containing the pyridine ring is used as the starting material, and it is prepared by halogenation and formylation. If the appropriate pyridine derivative is selected, the bromine atom is introduced with a brominating agent under specific conditions. Commonly used brominating agents include liquid bromine, N-bromosuccinimide (NBS), etc. Taking NBS as an example, in a suitable solvent, such as carbon tetrachloride, under the action of an initiator such as benzoyl peroxide, the heating reaction can make the bromine atom selectively replace the hydrogen atom at a specific position on the pyridine ring to obtain the bromine-containing pyridine intermediate. Subsequently, formyl groups are introduced through formylation. The commonly used method of formylation is the Vilsmeier-Haack reaction, the above intermediate is mixed with N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl), and the heating reaction, POCl reacts with DMF to form an active intermediate, and then reacts with the pyridine ring to introduce formyl groups at suitable positions. After post-treatment, the target product can be obtained.
Second, from the perspective of constructing the pyridine ring. The pyridine ring skeleton can be constructed by multi-step reaction, and at the same time, it can be cleverly designed so that the ring is pre-loaded with bromine and fluorine atom substituents, and then formyl groups are introduced in appropriate steps. For example, the pyridine ring is constructed by condensation and cyclization with β-ketone esters, ammonia and halogenated hydrocarbons as raw materials. During the reaction process, bromine and fluorine atoms are introduced into the corresponding positions of the pyridine ring by selecting suitable halogenated hydrocarbons, such as halogenated hydrocarbons containing bromine and fluorine. After the construction of the pyridine ring is completed, the formyl group is introduced at the 2-position of the pyridine ring according to the formylation method described above, and 6-bromo-3-fluoro-pyridine-2-formaldehyde is obtained through separation and purification.
Third, the coupling reaction with the help of metal catalysis. The coupling reaction is carried out with the metal-organic reagent containing formyl group using the pyridine derivative containing bromine and fluorine as the substrate under the action of a metal catalyst such as palladium catalyst. For example, by selecting a suitable palladium complex, such as tetra (triphenylphosphine) palladium (0), in a base and a suitable solvent system, the substrate is coupled with a formyl metal reagent, and the formyl group can be introduced into the 2-position of the pyridine ring. After subsequent treatment, the synthesis of the target product can be achieved.

6-Bromo-3-fluoropyridine-2-formaldehyde is an important member of organic chemicals. Looking at its physical properties, this substance is mostly solid under normal conditions, but its specific properties are still closely related to the surrounding environmental conditions. Its melting point and boiling point are the key to understanding its characteristics. Sadly, in the literature, there is no exact data detailing its melting point geometry. However, its boiling point, according to relevant explorations, is about 250-260 ° C. This boiling point value is not absolutely constant. If the ambient pressure changes, its boiling point will also fluctuate.
When it comes to solubility, 6-bromo-3-fluoropyridine-2-formaldehyde exhibits good solubility in organic solvents, such as common ethanol, dichloromethane, ethyl acetate, etc. This property is due to the interaction between the polar groups contained in its molecular structure and the molecules of the organic solvent. However, in water, because the polarity of the molecule and the polarity of the water molecule do not match, the solubility is quite limited.
As for its density, although there is no accurate measurement data, it is inferred from its molecular structure and the properties of similar compounds that its density should be slightly greater than that of water. As for the appearance, it is usually white to light yellow crystalline powder. The appearance of this color and morphology is also one of the important characteristics for the identification of this substance.
The physical properties of 6-bromo-3-fluoropyridine-2-formaldehyde lay the foundation for applications in many fields such as organic synthesis. Its dissolution characteristics are of great significance in the selection of solvents in organic reactions and the construction of reaction systems; its appearance and state provide an intuitive basis for the identification and use of substances in actual operation. Although some physical properties have not been precisely defined by exact experimental data, the method of analogy and inference can also provide useful guidance for research and application.

6-Bromo-3-fluoropyridine-2-formaldehyde, this is an organic compound. Its chemical properties are unique and it has many characteristics.
Let's talk about its aldehyde group first. The aldehyde group has high activity and can often participate in many reactions. For example, it can be added with nucleophiles, like with alcohols under the catalysis of acids or bases, it can generate acetals. Reacted with Grignard reagents, aldehyde carbonyl carbons are attacked by carbon anions in Grignard reagents, and hydrolyzed to form alcohols. In the oxidation reaction, the aldehyde group can be oxidized to a carboxyl group by a weak oxidant, such as Torun reagent or Feilin reagent, which presents a silver mirror reaction or generates a brick-red precipitate. It can also be oxidized to a carboxylic acid by a strong oxidant, such as potassium permanganate.
Let's talk about the properties of halogen atoms. Both bromine and fluorine atoms in the molecule are halogen atoms, but the two have different activities. Bromine atoms are relatively active. In nucleophilic substitution reactions, bromine atoms can be replaced by a variety of nucleophilic reagents, such as phenols replaced by hydroxyl groups, and amines replaced by amino groups. This substitution reaction often requires suitable catalysts and reaction conditions. Although fluorine atoms are highly electronegative, have high C-F bond energy, and are difficult to replace, they can significantly affect the distribution of molecular electron clouds and physical and chemical properties, resulting in higher stability and unique polarity of molecules, which play a role in their solubility, boiling point and other properties.
Pyridine rings also have important effects. Pyridine rings are aromatic, and nitrogen atoms make ring electron clouds unevenly distributed, which are alkaline and can form salts with acids. The differences in the distribution of electron clouds cause different reactivity at different positions on the pyridine ring. In 6-bromo-3-fluoropyridine-2-formaldehyde, the reactivity and selectivity of the pyridine ring are more complex due to the interaction of aldehyde group, bromine and fluorine atoms. Under specific conditions, electrophilic substitution or nucleophilic substitution reactions can occur.
In summary, 6-bromo-3-fluoropyridine-2-formaldehyde interacts with aldehyde group, halogen atom and pyridine ring, presenting rich and diverse chemical properties, which are of great value in the field of organic synthesis.

The price range of 6-bromo-3-fluoropyridine-2-formaldehyde in the market is difficult to determine. The price often varies due to many reasons, such as the source of the material, the difficulty of preparation, the situation of supply and demand, and the ups and downs of market conditions.
In the past, if the material is easy to obtain, the preparation method is simple, and the supply exceeds the demand, the price may tend to be easy. However, if the material is scarce, the preparation is complicated, and the delicate art is required, and the demand is too large, the price will be high.
Taste, the price of various chemical products in the market, such as this, may range from a few yuan per gram to several hundred yuan. According to the theory of 6-bromo-3-fluoropyridine-2-formaldehyde, if the supply is full of ordinary quality, the price per gram may be between a few yuan and tens of yuan. If you want high-purity products, and the preparation is very difficult, and there are various restrictions, the price may reach hundreds or even hundreds of yuan per gram.
However, the market situation is fickle, if you want to know the exact price, you should consult a chemical material dealer or visit a professional chemical trading platform to know the current accurate price.