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What are the physical properties of 6-bromo-2-fluoropyridine?
6. 2. Those who flow to it are rational, but have the characteristics of sinking and flowing.
6. Those who have the characteristics of condensation and sedimentation. If you put things containing water in the vessel, after a long time, they will gather at the bottom. Such as mud and water, sand sinks in the vessel, because of the weight of the vessel, they are all subject to gravity and sink. And their shape is mostly in the shape of a grain agglomerated, or as small as powder, or slightly larger as sand, but they all have a fixed shape, not like a flowing vessel.
2 Those who flow to it have the nature of flowing. Like the water of a river, it flows and flows, changing itself in the shape of a fixed container. The molecular force phase is weak, making it easy to flow and form. The flow of water can be easily blocked and can also fill the empty space. And it is affected by external forces. If it encounters an oblique surface, it will slope down and flow out.
Compared with the two, 6% is solid and solid, and it has the property of sedimentation and condensation; 2 flows to it and lives, with the shape of flow. The two have different physical properties, but they often coexist in the natural image. For example, there is mud at the bottom of a river, and water flows above them are interdependent and share the natural scene.
What are the chemical properties of 6-bromo-2-fluoropyridine?
Mercury, also known as "white", is a liquid at room temperature and has a silver-white color. It is a metallic element. Water has a unique property to it.
First, the active phase of water is low. Under normal conditions, oxygen is directly combined. However, if it is added to a certain extent, it will react with oxygen and generate mercury oxide. As the ancients said: "Mercury is exposed to fire, but it is not exposed to fire, and ghosts are hidden, and it is unknown that it exists." This means that mercury is easy to be destroyed under the action of fire, but it also reflects that it can be combined with other substances under the addition of water.
Second, mercury can form alloys with more gold, and this alloy is made of mercury. For example, mercury, gold and other metals can form mercury, and ancient people often took advantage of this property in metallurgy and other fields.
Third, there are many mercury compounds, and their properties vary. Such as mercury chloride, which is highly toxic; mercury sulfide, which is colored, that is, sand, has been used in plastics and other substances since ancient times.
Fourth, mercury is toxic, and it can be used slowly under normal conditions to form mercury vapor. Mercury vapor is very toxic. If people inhale it, it will cause serious damage to the body and digestive system. In ancient times, there were also cases caused by the use of mercury or mercury pollution.
In addition, the abundance of water in its transformation has been affected in many aspects such as the life, life, and exploration of the ancients. However, due to its toxicity, it is also necessary to be careful.
What are the main uses of 6-bromo-2-fluoropyridine?
The main use of the Liuxuan and Erchuan is the Tongli Waterway, which irrigates the fields, nourishes all things, and is related to the passage of boats and the needs of people's livelihood.
The water of the river, the source of life, the water of the Liuxuan and Erchuan, flows across the earth, moisturizes the soil, and makes the grains abundant. The ancestors of ancient times lived by the water, and led the water of the river to irrigate the fields. When planting in spring, the water is moist and fertile, and the seedlings can grow; when harvesting in autumn, the warehouses are enriched, all relying on the irrigation of this water. If there is no water of this river, the fields are dry and cracked, the farming is not prosperous, and the people's livelihood will be sleepy.
And the water of the river is the way of the boat. Since ancient times, the use of boats and boats has gradually expanded, and the six rivers and two rivers have been connected to all parties, so that goods can be transshipped and business travel can be exchanged. This not only benefits the circulation of the economy, but also promotes the integration of cultures. Goods from the north and the south are connected by water; the customs of the east and the west are connected by boats. The convenience of transportation has gradually integrated the world. The transmission of government orders and the prosperity of commerce all rely on the convenience of the rivers and boats.
Furthermore, the six rivers and two rivers nourish all living things. The fish, turtles, shrimp and crabs in the water are food for the people; the lush vegetation on the shore is the residence of birds and beasts. The ecology of water breeds thousands of lives and maintains the balance of nature. The surrounding wetlands and forests purify the air, regulate the climate, and create a livable environment for human beings.
And the six rivers and two rivers are used for people's livelihood, not only for food, irrigation, and transportation. Its water is clear and drinkable; its water can generate electricity, so that it can make use of living rooms and equipment. Although in ancient times, there was no technology for generating electricity today, but its work of moisturizing people's livelihood has already been profound. Therefore, the six rivers and two rivers have crucial uses for the national economy and people's livelihood. They are treasures given by heaven and earth, and they should be cherished and used well.
What are the synthesis methods of 6-bromo-2-fluoropyridine?
6-Bromo-2-thiophene acetic acid is an important intermediate in organic synthesis, and there are many synthesis methods. Although the synthesis of this compound is not specifically described in ancient books such as "Tiangong Kaiwu", the ancient chemical process ideas and the general methodology of organic synthesis can be discussed as follows:
** 1. Using thiophene as the starting material **
1. ** Bromination reaction **:
- Reacting thiophene with bromine in an appropriate solvent and catalyst, 2-bromothiophene can be obtained. If in glacial acetic acid solvent, a small amount of iron powder catalyzes, thiophene is slowly dropped into the glacial acetic acid solution of bromine, and the temperature control reaction can prevent the formation of polybrominates. This reaction is based on the principle of electrophilic substitution of aromatic hydrocarbons. The thiophene ring is rich in electrons and is easily electrophilic substitution with bromine.
- Reaction equation: $C_4H_4S + Br_2\ xrightarrow [] {Fe, CH_3COOH} C_4H_3BrS + HBr $
2. ** Carboxylation reaction **:
- Grignard reagent method: 2-bromothiophene reacts with magnesium chips in anhydrous ether to make Grignard reagent, that is, 2-thiophenyl magnesium bromide. Subsequent to carbon dioxide, and then hydrolyzed by acid, 6-bromo-2-thiophene acetic acid can be obtained. This is a common means of organic synthesis to construct carboxyl groups. The Grignard reagent is used to strengthen nucleophilicity and carbon dioxide nucleophilic addition.
- Reaction equation: $C_4H_3BrS + Mg\ xrightarrow [] {anhydrous ether} C_4H_3MgBrS $
$C_4H_3MgBrS + CO_2\ xrightarrow [] {} C_4H_3COOMgBrS\ xrightarrow [] {H ^ +} C_4H_3COOHS $
** Second, other thiophene-containing derivatives are used as raw materials **
1. ** If there is 2-thiophene acetic acid as the starting material **:
- It can be brominated. Because the carboxyl group is a meta-localization group, bromine atoms can be introduced into the thiophene ring at the 6 position under suitable brominating agents and conditions. For example, N-bromosuccinimide (NBS) is selected as the brominating agent, benzoyl peroxide (BPO) is selected as the initiator, and the reaction is heated in carbon tetrachloride solvent. This reaction uses a free radical mechanism, NBS provides bromine free radicals, which react with the thiophene ring under the action of the initiator.
- Reaction equation: $C_4H_3COOHS + NBS\ xrightarrow [] {BPO, CCl_4} C_4H_2BrCOOHS + HBr $
** III. Acquisition from raw materials and consideration of reaction conditions **
1. In terms of raw materials, thiophene has a wide range of sources and can be extracted from coal tar or petrochemical products. Magnesium chips, bromine and other reagents are commonly available.
2. In the reaction conditions, the bromination reaction should pay attention to temperature control and bromine drop rate to prevent polybromide; the preparation of Grignard reagent and subsequent reactions should be strictly anhydrous, otherwise Grignard reagent is easy to decompose. When brominating with 2-thiophene acetic acid as raw material, pay attention to the amount of initiator and reaction temperature control to ensure the selectivity of the reaction.
What are the precautions for 6-bromo-2-fluoropyridine in storage and transportation?
6. 2. In the storage environment, the river should pay attention to the general situation, so as to ensure its completeness and full effectiveness.
First, it is very important to be in the place where it exists. It is necessary to make high dryness and pass through the place to prevent moisture from invading. 6. 2. The river likes to be dry and refreshing. If it is in a tidal place for a long time, it is feared that it will be damaged, or the performance will be reduced. And it needs to be a fire source and a fire source. The two properties are non-flammable, but under the high temperature, it may also lead to accidents and endanger safety.
Second, the arrangement and placement of the storage environment are also studied. It is neat and orderly, and it cannot be piled up. In this way, it is convenient for inventory, and it can also avoid collision and friction with each other, resulting in the use of the surface and the beauty of the shadow.
Until then, the most important thing is to fix it properly. The 6-2 river type may be different, and the road is bumpy on the way. If it is not fixed properly, it is easy to shake and collide, causing damage. It can be firmly fixed with the help of cables, sheets, etc., with less displacement.
Furthermore, the performance of the tool should not be ignored. It is necessary to consider the advantages and disadvantages according to the characteristics, quantity and distance of the 6-2 river. If the road is not good, it is suitable for the shock absorption performance to be good, so that the earthquake can be improved.
And people are familiar with the nature of the 6-2 river, and take care of it on the way. Please pay attention to its safety. If it happens, we will deal with it immediately and ensure that the 6-2 rivers arrive at the destination safely and completely.
