6-bromo-2-cyanopyridine

6-Bromo-2-cyanopyridine is also an organic compound. It has a wide range of uses in the field of medicinal chemistry, and is mostly a key intermediate for the synthesis of various drugs. Taking anti-cancer drugs as an example, many anti-cancer drugs under development use 6-bromo-2-cyanopyridine as the starting material, through delicate chemical reactions, to build a specific molecular structure, giving the drug the ability to precisely attack cancer cells.
In the field of pesticide chemistry, it is also an indispensable ingredient for the synthesis of new pesticides. The creation of new insecticides and fungicides often relies on their unique chemical structures to achieve high efficiency, low toxicity and environmentally friendly effects. Due to the special activity of cyanyl and bromine atoms, it can participate in a variety of reaction pathways to build complex and biologically active molecules, thereby improving the control efficiency of pesticides against pests and diseases.
In the field of materials science, it has also made a name for itself. The synthesis of some functional materials, the introduction of 6-bromo-2-cyanopyridine, can optimize the electrical and optical properties of materials. For example, the preparation of organic optoelectronic materials can participate in the reaction to regulate the energy level structure of materials, improve charge transport performance, and contribute to the development of new optoelectronic devices.

6-Bromo-2-cyanopyridine is also an important compound in the field of organic synthesis. Its synthesis methods are diverse, and the details are as follows.
First, with 2-cyanopyridine as the starting material, 6-bromo-2-cyanopyridine can be obtained by bromination reaction. In appropriate reaction solvents, such as dichloromethane, chloroform and other halogenated hydrocarbon solvents, an appropriate amount of brominating reagents are added, such as bromine (\ (Br_ {2}\)), and Lewis acids such as iron tribromide (\ (FeBr_ {3}\)) or iron powder (\ (Fe\)) are used as catalysts. At the beginning of the reaction, bromine needs to be slowly added dropwise to a solution of 2-cyanopyridine and catalyst at low temperature, gradually heated to room temperature or moderately heated to promote the reaction. In this process, bromine atoms selectively replace hydrogen atoms at the 6-position of the pyridine ring. After post-treatment, such as extraction, washing, drying and column chromatography, pure 6-bromo-2-cyanopyridine can be obtained.
Second, starting from 6-bromo-pyridine-2-formic acid, it is prepared by amidation and dehydration. First, 6-bromopyridine-2-carboxylic acid is amidated with appropriate amine compounds (such as ammonia or methylamine, etc.) in the presence of a condensing agent (such as dicyclohexyl carbodiimide, DCC) and a catalyst (such as 4-dimethylaminopyridine, DMAP) in a suitable solvent (such as dichloromethane, N, N-dimethylformamide, DMF) to generate 6-bromopyridine-2-formamide. Subsequently, the amide intermediate is treated with a dehydrating agent (such as phosphorus pentoxide,\ (P_ {2} O_ {5}\)) or phosphorus oxychloride (\ (POCl_ {3}\)), and the dehydration reaction occurs under heating conditions to obtain 6-bromo-2-cyanopyridine. After the reaction is completed, the product is purified by distillation, recrystallization, etc.
Third, a halogenated aromatic hydrocarbon is prepared by a transition metal catalytic coupling reaction with a cyanylation reagent. For example, 2-bromo-6-halopyridine (the halogen atom can be chlorine, bromine, etc.) and cuprous cyanide (\ (CuCN\)) are heated in a polar aprotic solvent (such as N-methylpyrrolidone, NMP) in the presence of a divalent palladium catalyst (such as palladium acetate,\ (Pd (OAc) _ {2}\)) and a ligand (such as triphenylphosphine,\ (PPh_ {3}\)). This reaction is catalyzed by transition metals to achieve the coupling of halogen atoms and cyano groups to form 6-bromo-2-cyanopyridine. After the reaction is completed, the products are separated and purified by extraction, filtration, column chromatography and other operations.
All synthesis methods have their own advantages and disadvantages. In practical applications, when considering the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity, an appropriate method is selected to achieve the purpose of efficient synthesis of 6-bromo-2-cyanopyridine.

6-Bromo-2-cyanopyridine is an organic compound, and its physical properties are quite important. This compound is usually in a solid state at room temperature and pressure. Looking at its color, it is usually white to off-white powder or crystalline, with a clean appearance and uniform texture.
When it comes to melting point, 6-bromo-2-cyanopyridine has a specific value, which is about a certain range (the specific value depends on accurate determination). The characteristics of melting point are of great significance for identifying the compound and controlling its purity. When heated to this temperature, the substance gradually converts from a solid state to a liquid state, and this transformation process follows the laws of physical changes.
Its solubility is also one of the key physical properties. In organic solvents, 6-bromo-2-cyanopyridine exhibits a certain solubility. For example, in common organic solvents such as dichloromethane and chloroform, it can have moderate solubility. This property makes it possible to select a suitable solvent system in organic synthesis reactions to promote the smooth development of related reactions. However, in water, its solubility is relatively low, mainly due to the molecular structure of the compound, whose polarity is different from that of water molecules, making it difficult to form a good interaction with water. The density of
6-bromo-2-cyanopyridine is also an inherent physical property. Although the exact value needs to be determined experimentally and accurately, in general, its density reflects the compactness of the molecules of the substance. This physical property has indispensable reference value in practical operations involving material measurement and reaction system proportioning.
In addition, the stability of this compound is also a consideration of physical properties under specific conditions. In a normal temperature, dry and dark environment, 6-bromo-2-cyanopyridine can maintain a relatively stable state. However, if exposed to extreme conditions such as high temperature, humidity or strong light, it may undergo physical or chemical changes, which may affect its quality and performance.

6-Bromo-2-cyanopyridine is also an organic compound. The price of its market is difficult to determine. The change in its price is limited by many reasons.
Looking at the "Tiangong Kaiwu", the ancient theory of the value of the material is often related to the place, time, and amount of demand. In this world, the price of 6-bromo-2-cyanopyridine also follows this principle. The amount of production is one of the main reasons. If there are many producers, the supply exceeds the demand, and the price may drop; conversely, those who produce thin and seek to proliferate will increase in price. < Br >
The difficulty of its preparation also involves the price. The difficulty of making it requires labor and materials, and its price will increase; the ease of making it, the cost will decrease, and the price will follow.
Furthermore, the market demand has a great impact. If an industry is booming and needs 6-bromo-2-cyanopyridine as a material, its demand will increase, and the price will increase; if there is less demand, the price may stabilize and decrease.
And its purity is different, and the price is also different. High purity, more effort to make, the price is expensive; if the purity is slightly lower, the price may be slightly cheaper.
In summary, in order to determine the market value of 6-bromo-2-cyanopyridine, it is necessary to observe its production status, difficulty in preparation, market demand and purity.

6-Bromo-2-cyanopyridine is an organic compound, and many things need to be paid attention to when storing and transporting.
When storing, choose the first environment. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is quite sensitive to heat, high temperature can easily cause decomposition or other chemical reactions, which endangers safety. This compound needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed. The chemical properties of 6-bromo-2-cyanopyridine are active, and contact with these substances is very likely to cause violent reactions or generate harmful substances. Appropriate packaging materials, such as sealed glass bottles or plastic drums, are required to prevent leakage, and the packaging should be clearly marked with chemical labels and hazard warnings.
When transporting, make sure that the packaging is complete and safely loaded. Avoid bumps, vibrations and collisions during transportation to prevent leakage due to damaged packaging. Transportation vehicles should be equipped with corresponding types and quantities of fire fighting equipment and leakage emergency treatment equipment. Transport personnel should also be professionally trained to be familiar with the nature of the chemical and emergency treatment methods. If a leak occurs during transportation, emergency measures should be taken immediately, evacuate the surrounding people, strictly prohibit fire from approaching, and use appropriate methods for cleaning and disposal according to the leakage situation.
In conclusion, when storing and transporting 6-bromo-2-cyanopyridine, it is necessary to fully control environmental, packaging, personnel and other factors, and strictly follow relevant regulations and operating procedures to ensure safety and prevent accidents.