6 Bromo 2 Chloro 3 Iodopyridine
pyridine pyrrole pyrazine piperidine piperazine

6-Bromo-2-chloro-3-iodopyridine

    Specifications

    HS Code

    576853

    Name 6-Bromo-2-chloro-3-iodopyridine
    Molecular Formula C5H2BrClIN
    Molecular Weight 328.34
    Appearance Solid (predicted)
    Solubility Soluble in organic solvents (predicted)
    Purity Typically high - purity for research use
    Stability Should be stored under inert gas, away from light and heat
    Application Used in organic synthesis, pharmaceutical research

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    General Information
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    Frequently Asked Questions

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    What are the main uses of 6-Bromo-2-chloro-3-iodopyridine?
    6-Bromo-2-chloro-3-iodopyridine, this is an organic compound with a wide range of main uses.
    In the field of organic synthesis, it is often used as a key intermediate. Due to the presence of bromine, chlorine and iodine halogen atoms in its molecular structure, it is endowed with unique reactivity. Halogen atoms can react with many nucleophilic reagents, such as alcohols and amines, through nucleophilic substitution reactions to form chemical bonds such as carbon-oxygen and carbon-nitrogen, which help to synthesize organic compounds with diverse structures. For example, in pharmaceutical chemistry, specific functional groups can be introduced through nucleophilic substitution to develop drug molecules with specific biological activities.
    In the field of materials science, it also has important uses. Through the reactions it participates in, materials with special photoelectric properties can be synthesized. For example, through polymerization, it is introduced into polymer as a structural unit, so that the material exhibits unique electrical or optical properties, or is applied to organic Light Emitting Diode (OLED), solar cells and other fields, providing a way for the creation of new materials.
    In terms of scientific research and exploration, as a research object, it helps researchers to deeply explore the reaction mechanism and chemical properties of pyridine compounds. Through the study of various reactions, the theoretical knowledge of organic chemistry can be expanded, providing theoretical support and practical experience for the development of organic synthesis methodologies.
    In summary, 6-bromo-2-chloro-3-iodopyridine plays an indispensable role in organic synthesis, materials science and scientific research, and is of great significance to promote the development of related fields.
    What are 6-Bromo-2-chloro-3-iodopyridine synthesis methods?
    The synthesis method of 6-bromo-2-chloro-3-iodopyridine has been recorded in many ancient books. One method is to take pyridine as the base first, and gradually introduce bromine, chlorine and iodine atoms by halogenation. Initially, at a specific position of pyridine, appropriate brominating reagents, such as bromine, are combined with suitable catalysts, and in a suitable temperature and solvent environment, bromine atoms are preferentially attached to the pyridine ring to obtain bromine-containing pyridine intermediates.
    Then, this intermediate is chlorinated. Select an appropriate chlorination reagent, such as thionyl chloride or other chlorine sources, under certain reaction conditions, so that the chlorine atom can be successfully connected to the position of the chlorine atom in the target molecule, and then obtain a pyridine derivative containing bromine and chlorine.
    Finally, the derivative is iodized. Select an appropriate iodizing reagent, such as potassium iodide, to cooperate with an oxidizing agent, in a specific reaction system, to promote the iodine atom to successfully replace the group at a specific position, and finally form 6-bromo-2-chloro-3-iodopyridine.
    There are other methods, or the prototype of the pyridine ring is constructed first, and then halogenated in sequence. First, the compound containing bromine and chlorine and the nitrogen-containing raw materials are cyclized to initially construct a pyridine ring, and then iodine atoms are added by iodization. This way requires fine regulation of the reaction conditions to ensure the selectivity and yield of each step of the reaction, so that the reaction proceeds smoothly to the target product.
    Or other heterocyclic compounds are used as starting materials, and the ring opening, rearrangement and other series of reactions are carried out, and then halogenation modification can also achieve the purpose of synthesizing 6-bromo-2-chloro-3-iodopyridine. However, each method has its own advantages and disadvantages, and it is necessary to choose carefully according to various factors such as the availability of raw materials, the difficulty of reaction, and the high cost, in order to synthesize this compound efficiently.
    What are the physical properties of 6-Bromo-2-chloro-3-iodopyridine?
    6-Bromo-2-chloro-3-iodopyridine, this is an organic compound. Its physical properties are particularly important and are related to many chemical applications.
    First, let's talk about the appearance, usually in a solid state. Its specific form may be crystalline, delicate and regular, just like the microscopic crystal landscape of nature, reflecting the wonders of the chemical world.
    When it comes to the melting point, this substance has a high melting point, and it takes a certain amount of heat to disintegrate its lattice structure and convert it from solid to liquid. Just like ice, it takes a long time to warm the sun to melt. The exact value of its melting point is the key to the precise grasp of many chemical experiments and industrial production, and it is related to the reaction process and product purity.
    In terms of boiling point, it is also a considerable value. When enough energy is applied to overcome the intermolecular forces, it will boil and vaporize. This process is like a phoenix nirvana, sublimating from liquid to gaseous state, participating in a wider chemical reaction space. The accurate determination of boiling point is of great significance for chemical operations such as distillation and separation, which can ensure that the components are separated in sequence and realize the purification and enrichment of substances.
    Solubility is also an important property. In organic solvents, such as common ethanol, ether, etc., its solubility is acceptable. The intermolecular forces match each other, so that they can be evenly dispersed in the solvent to form a uniform and stable system, like a fish getting water, freely shuttling through the molecular gap of the solvent. However, the solubility in water is not good, because of the large difference between the molecular structure and the polarity of the water molecule, it is difficult to form an effective interaction, just like oil and water, distinct.
    Density is a specific value, reflecting the mass of the substance per unit volume. This property provides an important basis for determining the dosage of substances and container specifications during preparation, storage and transportation, just like a measure of the "weight" of substances, indispensable.
    The above physical properties are like a cornerstone for the synthesis and application of 6-bromo-2-chloro-3-iodopyridine in high-rise buildings, laying a solid foundation for in-depth exploration of its chemical nature and wide application.
    What are the chemical properties of 6-Bromo-2-chloro-3-iodopyridine?
    6-Bromo-2-chloro-3-iodopyridine is one of the organic compounds. Its chemical properties are well-researched.
    The activity of its halogen atom is the first. This compound contains three halogen atoms: bromine, chlorine and iodine. The activity of bromine atom is quite high. In the nucleophilic substitution reaction, it is easy to be attacked by nucleophilic reagents and leave to combine with nucleophilic reagents. Although the activity of chlorine atom is slightly less than that of bromine, it can also participate in nucleophilic substitution under suitable conditions. The activity of iodine atom is between the two.
    Furthermore, its pyridine ring has electronic effect. The pyridine ring is an electron-deficient aromatic ring, and the nitrogen atom has an electron-sucking induction effect and a conjugation effect, resulting in a decrease in the electron cloud density on the ring. In the electrophilic substitution reaction, the reactivity is lower than that of the benzene ring, and the substituent is mostly introduced into the pyridine ring nitrogen atom.
    Also, 6-bromo-2-chloro-3-iodopyridine contains polyhalogen atoms, which can be used as a synthesis intermediate and has a wide range of uses in the field of organic synthesis. For example, it can be used for a series of reactions to construct complex organic molecular structures, or to prepare materials and drugs with specific functions.
    At the same time, the stability of the compound is also concerned Halogen atoms exist or affect their stability. Under high temperature, light and other conditions, reactions such as removal of halogen atoms may be triggered, resulting in structural changes.
    The chemical properties of 6-bromo-2-chloro-3-iodopyridine are determined by the synergistic effect of halogen atoms and pyridine rings in its structure. It is of great significance in organic synthesis, materials science and other fields, and is worthy of in-depth investigation.
    What is the price range of 6-Bromo-2-chloro-3-iodopyridine in the market?
    6-Bromo-2-chloro-3-iodopyridine is in the market, and its price range is difficult to determine. The price of this substance often varies for many reasons. First, the difficulty of preparation is different. If the synthesis path is complicated, different raw materials and harsh reaction conditions are required, such as specific catalysts, precise temperature and pressure control, and there are many steps and low yield, the cost will be high, and the price will also rise. Second, the state of supply and demand determines its price. If the demand for this substance increases sharply in the fields of pharmaceutical research and development, chemical synthesis, etc., and the supply is limited, the price will rise; conversely, if the demand is weak and the supply is abundant, the price will decline. Third, the price of raw materials is also the main factor. If the price of bromide, chloride, iodide and other raw materials required for its preparation fluctuates, the price of 6-bromo-2-chloro-3-iodopyridine will also be affected by it.
    Looking at the past market, the price of these fine chemicals may vary from time to time. Sometimes in some regions, due to the rise of specific industries, the demand rises sharply, and the price may reach tens of yuan per gram; and when the supply is sufficient and the demand is sluggish, the number of yuan per gram is also possible. However, in order to obtain an accurate price, it is necessary to carefully observe the current market dynamics and consult the chemical raw material suppliers and relevant trade platforms to obtain a more accurate price.