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6-Bromo-1H-Pyrazolo [4,3-C] What is the main use of Pyridine?
6-Bromo-1H-Pyrazolo [4,3-c] pyridine, Chinese name 6-bromo-1H-pyrazolo [4,3-c] pyridine, this substance has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry.
The development of Guanfu Medicine, the research and development of many antimalarial drugs, 6-bromo-1H-pyrazolo [4,3-c] pyridine all play an important role. Malaria has been raging for a long time and is a disaster to the common people. The research of this agent can effectively curb the reproduction of malaria parasites, reduce diseases and save lives. It has a unique activity check point in molecular structure, which can interact with specific proteins of Plasmodium, block key physiological processes, and make it difficult for Plasmodium to survive.
In the exploration of anti-tumor drugs, it is also indispensable. The disease of tumors, the world talks about the color change. This compound can participate in the construction of a new molecular framework of anti-cancer drugs. With its special structure, it may be able to precisely act on key targets of tumor cells, inhibit tumor cell proliferation, induce apoptosis, and bring new hope for solving cancer problems.
In addition to medicine, it has also emerged in the field of materials science. Organic optoelectronic materials are booming. 6-bromo-1H-pyrazolo [4,3-c] pyridine has been cleverly modified and integrated to optimize the optoelectronic properties of materials. If applied to organic Light Emitting Diode (OLED), it may improve its luminous efficiency and stability, make the display picture clearer and brighter, and contribute to the innovation process of display technology.
In short, 6-bromo-1H-pyrazolo [4,3-c] pyridine, with its unique structure, has shown important uses in many fields such as medicine and materials science, contributing to human health and technological progress.
What are the synthesis methods of 6-Bromo-1H-Pyrazolo [4,3-C] Pyridine
6 - Bromo - 1H - Pyrazolo [4,3 - c] pyridine is an important organic compound, and there are many synthesis methods. The following are commonly seen:
First, the method of using nitrogen-containing heterocyclic compounds as starting materials. Pyridine derivatives with suitable substituents are often taken to introduce the pyrazole ring structure through specific reactions. For example, under the action of strong bases, pyridine derivatives are first condensed with hydrazine-containing reagents to construct a pyrazole ring frame, and then brominated to introduce bromine atoms at designated positions. The reaction conditions need to be carefully regulated. Because the selectivity of the bromination reaction is quite critical, temperature and the proportion of reagents used will affect the yield and purity of the product.
Second, synthesize by cyclization reaction. Select chain-like compounds containing appropriate functional groups and make them cyclize within molecules under suitable catalyst and reaction conditions. For example, a chain-like precursor compound containing nitrogen and double bonds is catalyzed by a metal catalyst, and the target pyrazolopyridine structure is formed by cyclization reaction, and then brominated. In this approach, the mechanism of cyclization is complex, and the choice and dosage of catalysts have a significant impact on the reaction process, and attention should be paid to possible side reactions during the reaction process.
Third, with the help of a multi-step reaction strategy. The target molecule is gradually constructed from simple raw materials. First, the intermediate containing part of the structure is synthesized, and then the multi-step functional group conversion and cyclization reaction is carried out. For example, the intermediate containing pyridine fragment is prepared first, through a series of substitution and addition reactions, and then reacts with the related reagents of pyrazole ring synthesis, and finally completes the synthesis of 6-Bromo-1H-Pyrazolo [4,3-c] pyridine. This process is complicated, and each step of the reaction needs to be strictly controlled to ensure the purity and yield of the intermediate, so as to smoothly promote the subsequent reaction.
Each synthesis method has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, cost and product purity, and carefully select the appropriate synthesis route to obtain the target compound efficiently.
What is the market price of 6-Bromo-1H-Pyrazolo [4,3-C] Pyridine
6 - Bromo - 1H - Pyrazolo [4,3 - c] Pyridine is an organic compound. Its market price fluctuates for a variety of reasons.
The first to bear the brunt is the cost of raw materials. The synthesis of this compound requires specific starting materials. If the raw materials are scarce or the production cost is high, the price of 6 - Bromo - 1H - Pyrazolo [4,3 - c] Pyridine will also be affected by it. For example, if the key raw materials required are limited in supply, the purchase price will rise, which will inevitably be passed on to the price of the finished product.
Furthermore, the difficulty of the synthesis process has a profound impact on the price. If the synthesis of this compound requires complicated steps, special reaction conditions, such as high temperature, high pressure, or the use of expensive catalysts, and the reaction yield is not good, this will push up production costs, which in turn will lead to higher market prices.
The balance between supply and demand in the market is also an important factor. If the market demand for 6 - Bromo - 1H - Pyrazolo [4,3 - c] Pyridine is strong, but the supply is relatively insufficient, the price will rise due to the shortage of supply; conversely, if the market demand is low and the supply is excessive, the price will face downward pressure.
In addition, the price may vary depending on the manufacturer. Large and scale-effective manufacturers have high production efficiency, good cost control, and relatively close prices; while small manufacturers have high costs due to lack of scale advantages, and their pricing may be relatively high.
In summary, the market price of 6-Bromo-1H-Pyrazolo [4,3-c] Pyridine does not have a fixed value, but changes dynamically according to the above factors. To know its exact price, when you check the relevant chemical product trading platform in real time and consult a professional chemical raw material supplier, you can get an accurate quotation.
What are the physicochemical properties of 6-Bromo-1H-Pyrazolo [4,3-C] Pyridine?
6-Bromo-1H-pyrazolo [4,3-c] pyridine is one of the organic compounds. Its physical and chemical properties are particularly important, which are related to the use and reaction characteristics of this compound.
In terms of its physical properties, under normal conditions, 6-bromo-1H-pyrazolo [4,3-c] pyridine is mostly in a solid state. The melting point of this compound is a key parameter for distinguishing its purity and characteristics. However, its exact melting point varies depending on the preparation method and purity, and is generally within a certain temperature range. Its appearance may be white to light yellow crystalline powder. This color and morphology can be changed by the synthesis process and the presence or absence of impurities.
As for chemical properties, the presence of bromine atoms in 6-bromo-1H-pyrazolo [4,3-c] pyridine gives it significant reactivity. Bromine atoms are prone to substitution reactions and can interact with many nucleophiles. For example, under appropriate reaction conditions, nucleophiles can attack the carbon atoms attached to the bromine atoms, causing the bromine atoms to leave, and then generate new organic compounds. This substitution reaction has a wide range of uses in the field of organic synthesis and can be used to construct more complex organic molecular structures.
Furthermore, the heterocyclic structure of pyrazolopyridine also endows the compound with unique electronic properties and chemical stability. The nitrogen atom in this heterocyclic structure can participate in a variety of chemical reactions, such as coordination reactions. Because of its lone pair of electrons, nitrogen atoms can coordinate with metal ions to form metal complexes, which may have potential applications in the fields of materials science and catalysis.
In addition, the solubility of 6-bromo-1H-pyrazolo [4,3-c] pyridine in different solvents is also an important physical and chemical property. It may have a certain solubility in polar organic solvents, but may have low solubility in non-polar solvents. This difference in solubility has important guiding significance in the separation, purification and choice of reaction medium.
6-Bromo-1H-Pyrazolo [4,3-C] In which areas is Pyridine used?
6 - Bromo - 1H - Pyrazolo [4,3 - c] pyridine is an organic compound. It has applications in many fields, as detailed below.
In the field of medicinal chemistry, this compound has great potential. Due to its unique chemical structure, it can be used as a key intermediate for the synthesis of a variety of drugs. Organic molecules with specific structures, which cover drug development, are modified and transformed to obtain substances with specific pharmacological activities. The structural characteristics of 6 - Bromo - 1H - Pyrazolo [4,3 - c] pyridine enable it to interact with targets in organisms, or can be used to develop new therapeutic drugs, such as anti-cancer drugs, antiviral agents, etc. For example, by chemically modifying it, it can adjust its affinity with specific cancer cell receptors, thereby precisely targeting cancer cells and inhibiting their growth and spread.
In the field of materials science, it also has outstanding performance. The development of organic materials is changing rapidly, and this compound may participate in the construction of new organic optoelectronic materials. In the study of organic light emitting diodes (OLEDs) and organic solar cells, organic molecules with specific electronic structures and optical properties are crucial. 6 - Bromo - 1H - Pyrazolo [4,3 - c] pyridine can be introduced into larger molecular systems or polymers by appropriate chemical means, giving the material unique photoelectric properties, such as changing the luminous color of the material, improving the photoelectric conversion efficiency, etc., providing the possibility for the creation of new optoelectronic devices.
Furthermore, in the field of organic synthetic chemistry, 6 - Bromo - 1H - Pyrazolo [4,3 - c] pyridine is an important synthetic building block. Chemists can use its bromine atom activity to introduce different functional groups into molecules through many classic organic reactions, such as nucleophilic substitution reactions, metal-catalyzed coupling reactions, etc., to construct complex and diverse organic compounds. This helps to expand the boundaries of organic synthesis, create novel organic molecular structures, and contribute to the development of organic chemistry theory and practice.
In summary, 6-Bromo-1H-Pyrazolo [4,3-c] pyridine has shown broad application prospects in the fields of medicine, materials, and organic synthesis, and is of great significance to the progress and innovation in related fields.