6-Bromo-1H-imidazo[1,2-a]pyridine-8-amine

6 - Bromo - 1H - imidazo [1,2 - a] pyridine - 8 - amine is an organic compound with a unique chemical structure. This compound is composed of the parent nucleus structure of imidazopyridine.
In the imidazopyridine parent nucleus, the pyridine ring and the imidazole ring are fused in a specific way to construct a unique double-ring structure. In this structure, there is a bromine atom attached at position 6. The bromine atom has a certain electronegativity, which has a great influence on the electron cloud distribution and chemical activity of the whole molecule. It can change the molecular polarity, affect its solubility in different solvents, and can participate in many chemical reactions as a reaction check point.
However, there is an amino group at position 8, and the amino group is an electron donor group, which also has a significant effect on the distribution of molecular electron cloud density, enhancing the alkalinity of the molecule, making it able to participate in many nucleophilic substitution reactions as a nucleophilic reagent, which is of great significance in the field of organic synthesis.
Overall, the chemical structure of 6-Bromo-1H-imidazo [1,2-a] pyridine-8-amine, due to the ingenious arrangement of bromine atoms and amino groups on a specific dicyclic parent nucleus, endows the compound with unique chemical properties and potential reactivity, and may have important applications in organic synthesis and medicinal chemistry.

6-Bromo-1H-imidazo [1,2-a] pyridine-8-amine, an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. In drug development, compounds with specific structures can be chemically reacted to derive drug molecules with biological activity, and the unique structure of the compound may lay the foundation for the synthesis of novel drugs.
In the field of materials science, or can participate in the preparation of functional materials. For example, in the synthesis of organic semiconductor materials, its structural characteristics may endow materials with unique electrical and optical properties, providing the possibility for the development of new optoelectronic devices, such as organic Light Emitting Diodes, solar cells, etc.
At the level of scientific research and exploration, it is an important substance for scientists to explore the relationship between chemical reaction mechanism, molecular structure and properties. Through the study of its participation in reactions, it can gain in-depth insight into various chemical processes and help the development and improvement of chemical theory.
Furthermore, it may also have potential applications in the field of pesticide chemistry. After rational structural modification and modification, new pesticides with high efficiency, low toxicity and environmental friendliness may be developed to ensure agricultural production and resist pest attacks. In short, 6-Bromo-1H-imidazo [1,2-a] pyridine-8-amine has important value and broad application prospects in many fields.

The synthesis method of 6-bromo-1H-imidazolo [1,2-a] pyridine-8-amine has been known in ancient times, and there are many kinds. Today, I will describe one or two of them.
First, a specific pyridine derivative is used as the starting material. First, the pyridine derivative meets the bromine-containing reagent under suitable reaction conditions, such as in a suitable solvent, the temperature and reaction time are controlled, and the bromine atom is skillfully introduced into the specific position of the pyridine ring to obtain the bromine-containing pyridine intermediate. This process requires attention to the precise regulation of the amount of bromine-containing reagent and the reaction temperature to avoid side reactions.
Then, the bromopyridine-containing intermediate is fused with imidazole compounds, and with the help of catalysts, it undergoes a cyclization reaction to construct the imidazolo [1,2-a] pyridine structure. In this step, the choice of catalyst is quite critical, and different catalysts have a great impact on the reaction rate and yield, so careful choice is required. And the pH of the reaction environment, temperature and other factors also need to be carefully controlled to make the reaction proceed smoothly and efficiently generate the target product 6-bromo-1H-imidazolo [1,2-a] pyridine-8-amine.
Second, another path can also be used. The imidazole derivative is used as the starting material to modify the imidazole ring first, and a specific substituent is introduced to lay the foundation for the subsequent construction of the pyridine ring. Then, through a series of reactions, such as nucleophilic substitution, cyclization, etc., the pyridine ring is gradually built, and bromine atoms and amino groups are introduced at appropriate stages. This method requires careful consideration of the reaction conditions of each step, from the ratio of reactants to the reaction time, temperature, solvent, etc., all of which affect the quality and yield of the final product. After each step of the reaction, it is necessary to remove impurities by suitable separation and purification methods to ensure that the reaction progresses steadily towards the target direction, and finally obtain pure 6-bromo-1H-imidazolo [1,2-a] pyridine-8-amine.

6 - Bromo - 1H - imidazo [1,2 - a] pyridine - 8 - amine is an organic compound. Its physical and chemical properties are unique and crucial in the field of organic synthesis.
Looking at its physical properties, under normal conditions, this compound is mostly in a solid state. Due to the characteristics of its molecular structure, its melting point is quite high. Specifically, accurately determined melting point values can be obtained under specific experimental conditions. Its solid appearance, or white to light yellow crystalline powder, this color and morphology are due to molecular interactions and crystal structures.
As for solubility, this compound has different solubility in common organic solvents. It exhibits good solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF). This is due to the polarity of these solvents, which can form hydrogen bonds or other intermolecular forces with 6-Bromo-1H-imidazo [1,2-a] pyridine-8-amine molecules to promote dissolution. However, in non-polar organic solvents such as n-hexane and toluene, its solubility is poor, because the molecular polarity does not match the non-polar solvent, and the intermolecular forces are not sufficient to overcome the lattice energy.
In terms of its chemical properties, the bromine atom of 6-Bromo-1H-imidazo [1,2-a] pyridine-8-amine has high reactivity with the amino group. Bromine atoms can participate in nucleophilic substitution reactions, such as reacting with nucleophiles such as alcohols and amines to form new carbon-heteroatomic bonds. This reaction mechanism is based on the attack of the nucleophilic tester on the carbon atoms attached to the bromine atom, and the bromine ion leaves as a leaving group. The amino group can participate in a variety of reactions, such as reacting with acids to form salts, or participating in condensation reactions, reacting with compounds such as aldides and ketones to form nitrogen-containing heterocyclic compounds. These reactive activities are derived from the electron-withdrawing effect of bromine atoms and the electron-donating effect of amino groups, which change the electron cloud density of some carbon atoms and nitrogen atoms in the molecule, making it easy to undergo chemical reactions.
The physicochemical properties of 6 - Bromo - 1H - imidazo [1,2 - a] pyridine - 8 - amine lay the foundation for its application in organic synthesis, pharmaceutical chemistry and other fields. Its unique properties make it a key intermediate to participate in the synthesis of a variety of complex organic compounds, and then provide important support for research and development in related fields.

I look at the market price range of "6 - Bromo - 1H - imidazo [1,2 - a] pyridine - 8 - amine" you are inquiring about. This is a fine chemical product. However, the market price often changes for many reasons, and it is difficult to determine a certain number.
First, the purity of the product is the key. If the purity is extremely high, it is almost flawless, such as more than 99%, the price must be high. To obtain this high-purity product, the preparation method needs to be extremely delicate, the process is complicated, the materials used must be exquisite, and the cost is high. The price may be tens or even hundreds of yuan per gram.
Second, the amount purchased also has an impact. If the purchase volume is very large, such as in kilograms, the merchant may reduce the price slightly due to the profit of the batch, and the price per gram may be reduced to a few yuan to tens of yuan. However, if only a small amount is purchased, such as in milligrams, the price per gram may rise sharply to more than 100 yuan to cover the cost of its operation.
Third, the producer and the source also affect the price. Well-known large factories have exquisite craftsmanship, strict quality control, and high quality products, and their prices are high. And some small factories produce, although they can also be used, the quality may vary, and the price may be slightly lower.
Fourth, the supply and demand of the city cannot be ignored. If there are many buyers of this item, and the producers are limited, the supply will exceed the demand, and the price will rise. On the contrary, if the supply exceeds the demand, the merchant will sell the goods or reduce the price.
In summary, the market price of "6 - Bromo - 1H - imidazo [1,2 - a] pyridine - 8 - amine" varies from a few yuan per gram or a few yuan to more than a hundred yuan. It is difficult to determine the exact range, which depends on the above factors.