6 Benzyloxy 3 Bromopyridine
pyridine pyrrole pyrazine piperidine piperazine

6-Benzyloxy-3-bromopyridine

    Specifications

    HS Code

    399948

    Chemical Formula C12H10BrNO
    Molecular Weight 264.12 g/mol
    Appearance Solid (usually white or off - white)
    Melting Point N/A (specific value needs experimental determination)
    Boiling Point N/A (specific value needs experimental determination)
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Pka N/A (specific value needs experimental determination)
    Density N/A (specific value needs experimental determination)
    Flash Point N/A (specific value needs experimental determination)

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    General Information
    Where to Buy 6-Benzyloxy-3-bromopyridine in China?
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    Frequently Asked Questions

    As a leading 6-Benzyloxy-3-bromopyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 6-Benzyloxy-3-bromopyridine?
    6-Benzyloxy-3-bromopyridine is a compound that has attracted much attention in the field of organic synthesis. Its main use, first as a key intermediate, is widely used in the field of medicinal chemistry. In the process of many drug research and development, it is often used as a starting material to construct complex molecular structures with specific biological activities through multiple delicate reactions. Due to its unique chemical structure, it can modify and modify molecules through various chemical reactions to meet the needs of combining drugs with targets.
    In the field of pesticide synthesis, it also has its important application. It can be used as an important cornerstone for the synthesis of new pesticides, helping to develop high-efficiency, low-toxicity and environmentally friendly pesticide varieties. Through the optimization and derivatization of its structure, pesticides are endowed with more excellent insecticidal, bactericidal or herbicidal properties.
    In addition, in the field of materials science, 6-benzyloxy-3-bromopyridine also shows potential application value. Or can participate in the preparation of functional materials, endowing materials with unique optical, electrical or other special properties, thereby meeting the needs of different fields for special materials. In short, because of its structural properties and chemical reactivity, it has important uses in many fields, providing a broad space and possibility for many research and applications.
    What are 6-Benzyloxy-3-bromopyridine synthesis methods?
    The synthesis method of 6-benzyloxy-3-bromopyridine is an important topic in the field of organic synthesis. Past books have reported that there are various synthesis paths. First, it can be started from 3-bromo-6-hydroxypyridine and reacted in an alkaline environment with benzyl halide as benzylation reagent. The base can be selected from potassium carbonate, sodium carbonate, etc., and the organic solvent can be selected from acetonitrile, N, N-dimethylformamide, etc. The reaction conditions are mild and the benzylation selectivity is good, but the activity of benzyl halide may vary, which affects the yield.
    Second, starting from 3-bromopyridine, the pyridine ring is first metallized to activate at a specific position, and then reacted with benzyloxy reagents. Metallizing reagents such as n-butyllithium, etc., are subsequently reacted with benzyloxy sources such as benzyl alcohol derivatives. This approach can precisely locate the introduction of benzyloxy groups, but the metallization reaction conditions are harsh, and an anhydrous and oxygen-free environment is required, which requires high operation requirements.
    Another method is to introduce bromine atoms through halogenation reaction using 6-benzyloxy pyridine as raw material. The halogenation reagent can be selected from N-bromosuccinimide (NBS), etc., and reacts in the presence of suitable solvents and initiators. The advantage of this method is that the raw materials are relatively easy to obtain, but the regional selectivity of the halogenation reaction needs to be carefully controlled, otherwise the purity and yield of the target product may be affected by the production of by-products. All synthesis methods have their own advantages and disadvantages, and the appropriate path should be carefully selected according to the actual demand, raw material availability, cost considerations and other factors, so as to achieve the purpose of efficient synthesis of 6-benzyloxy-3-bromopyridine.
    What are the physical properties of 6-Benzyloxy-3-bromopyridine?
    6-Benzyloxy-3-bromopyridine is an important compound in organic chemistry. Its physical properties are particularly critical and are related to many chemical applications.
    Looking at its appearance, it often takes the form of white to off-white crystalline powder, which is easy to store and operate. Its melting point is quite specific, about a certain temperature range, which can help chemists identify and purify it. The determination of the melting point of the cover is a common means to identify the purity and characteristics of compounds.
    Solubility is also an important physical property. In organic solvents such as dichloromethane and chloroform, 6-benzyloxy-3-bromopyridine has good solubility and can be uniformly dispersed, which is conducive to participating in various organic reactions. However, in water, its solubility is very small, because the molecular structure of the compound has a large proportion of hydrophobic groups and weak interaction with water molecules.
    Furthermore, its boiling point is also of characterization significance. Under specific pressure conditions, at a certain temperature, 6-benzyloxy-3-bromopyridine will change from liquid to gaseous state. The data of boiling point is indispensable in operations such as distillation separation, which can help chemists to achieve effective separation of the compound from other substances.
    In addition, the density of 6-benzyloxy-3-bromopyridine is also a physical parameter. Its density determines the mass of the substance in the same volume. In terms of experimental preparation and reaction measurement, this parameter needs to be accurately considered to ensure the accuracy and reproducibility of the experiment.
    In summary, the physical properties of 6-benzyloxy-3-bromopyridine, such as appearance, melting point, solubility, boiling point and density, are all indispensable elements in the research and application of organic chemistry. Chemists can design experiments based on these characteristics to achieve effective utilization and control of the compound.
    What are the chemical properties of 6-Benzyloxy-3-bromopyridine?
    6-Benzyloxy-3-bromopyridine, this is an organic compound with unique chemical properties. In its structure, the bromine atom is connected to the pyridine ring, and the benzyloxy group is also connected to the specific position of the pyridine ring, and the structure determines the properties.
    From the theory of reactivity, bromine atoms are quite active, and due to their electronegativity differences, they are prone to nucleophilic substitution reactions. Under suitable conditions, nucleophiles can attack the carbon atoms attached to the bromine atom, and the bromine ions leave to form new compounds. For example, by reacting with sodium alcohol, ether products can be formed; by reacting with amines, nitrogen-containing derivatives can be prepared, which is a common strategy for constructing complex organic molecules. The
    pyridine ring is aromatic, and its electron cloud distribution is special, so that the carbon atoms on the ring have a certain electrophilicity, which can occur electrophilic substitution reaction. However, due to the existence of bromine atoms and benzyloxy groups, the substitution position is affected by the localization effect of the two. Benzyloxy is a power supply group, which belongs to the ortho and para-localization groups; although bromine atoms absorb electrons, they have lone pairs of electrons, and also have ortho and para-localization effects. Combining the two, the electrophilic substitution reaction is more likely to occur at a specific position of the pyridine ring. In the
    benzyloxy group, the benzyl group has a certain stability and can be removed under specific conditions to release hydroxyl groups. This property can be used to protect hydroxyl groups in organic synthesis. After the reaction is completed, the protective group is sel
    In addition, the solubility of 6-benzyloxy-3-bromopyridine is also worthy of attention. Due to the presence of polar pyridine rings and non-polar benzyl groups, it has better solubility in organic solvents such as dichloromethane and chloroform, and relatively poor solubility in water. This solubility characteristic is crucial in the separation, purification and reaction medium selection of compounds. In short, 6-benzyloxy-3-bromopyridine is rich in chemical properties and has a wide range of uses in the field of organic synthesis.
    What is the price range of 6-Benzyloxy-3-bromopyridine in the market?
    6-Benzyloxy-3-bromopyridine is on the market, and its price is uncertain, due to many factors.
    First, the amount has a great impact. If the quantity is huge, the merchant may give a discount due to economies of scale, and the price may decrease; if the quantity is small, the supplier may increase the price due to cost considerations.
    Second, the quality is also the key. High quality, after strict purification and testing, those who meet high standards will be expensive; if the quality is lacking, there are many impurities, and they do not meet the required standards, the price will drop.
    Third, the state of supply and demand will affect the price. < Br >
    Fourth, the cost of production is related to the process. Preparation requires difficult processes and high-priced raw materials, and the cost is high, and the market price is also high; if the process is simple and the raw materials are cheap, the price is low.
    Also, different regions have different prices due to differences in taxes, transportation costs, market competition, etc. Prosperous cities, high operating costs, or higher prices than remote areas.
    In summary, the price of 6-benzyloxy-3-bromopyridine on the market ranges from a few yuan to tens of yuan per gram. The actual price must be determined by consulting the supplier in detail according to the specific transaction conditions.