6-Amino-3-bromo-2-methylpyridine

6-Amino-3-bromo-2-methylpyridine is one of the organic compounds. Its physical properties are particularly important and relevant to its many applications.
Looking at its appearance, it often takes the form of a white-like to light yellow crystalline powder. This form is easy to identify and operate, and it is easy to handle in many chemical processes.
When it comes to the melting point, it is about a specific temperature range. The accurate determination of the melting point is crucial for the determination of the purity of the compound. High-purity 6-amino-3-bromo-2-methylpyridine has a relatively stable and accurate melting point. If it contains impurities, the melting point may be offset.
Solubility is also an important physical property. In organic solvents, such as common ethanol, dichloromethane, etc., there is a certain solubility. However, in water, the solubility is relatively limited. This property determines its applicability in different reaction systems and separation processes. In organic synthesis reactions, according to its solubility, suitable solvents can be selected to promote the reaction, improve the reaction efficiency and yield.
Furthermore, its density is also an important parameter. Although the density value may be relatively fixed, in specific application scenarios, such as the design of mixed systems, material separation, etc., its density characteristics need to be accurately considered. The physical properties of 6-amino-3-bromo-2-methylpyridine, such as appearance, melting point, solubility, density, etc., play a key role in chemical synthesis, drug development, materials science, and many other fields, laying the foundation for related research and applications.

6-Amino-3-bromo-2-methylpyridine is also an organic compound. Its chemical properties are well-researched.
In terms of its acidity and alkalinity, the amino group (\ (- NH_ {2}\)) is weakly basic. In an appropriate acidic environment, the amino group can accept protons and form a positively charged ammonium ion (\ (- NH_ {3 }^{+}\)） 。
In terms of its reactivity, the bromine atom (\ (-Br\)) is one of the important functional groups of this molecule. It can participate in nucleophilic substitution reactions. In case of appropriate nucleophilic reagents, the bromine atom can be replaced to form new compounds. For example, if there are nucleophiles containing hydroxyl groups (\ (-OH\)), under suitable conditions, bromine atoms may be replaced by hydroxyl groups to obtain hydroxyl-containing pyridine derivatives.
Furthermore, although the chemical activity of methyl group (\ (- CH_ {3}\)) is slightly lower than that of bromine atoms and amino groups, it also affects the electron cloud distribution and spatial structure of the molecule. The electron-giving effect of methyl group may change the electron cloud density on the pyridine ring, which in turn affects the activity and selectivity of the molecule in the electrophilic substitution reaction.
The reaction check point of the molecule has a specific selectivity in the electrophilic substitution reaction due to the interaction of the amino group and the bromine atom. The amino group is an ortho-and para-localization group, and the bromine atom is also an ortho-and para-localization group. The synergistic effect of the two makes the electrophilic reagents more inclined to attack specific positions on the pyridine ring, which is especially critical for the synthesis of pyridine derivatives with specific structures.
In addition, the nitrogen atom in this compound can participate in the coordination reaction and form coordination compounds with metal ions, etc., showing unique chemical behaviors. All of these are important chemical properties of 6-amino-3-bromo-2-methylpyridine.

The common synthesis methods of 6-amino-3-bromo-2-methylpyridine generally include the following.
First, 2-methyl-3-nitropyridine is used as the starting material. First, 2-methyl-3-nitropyridine is brominated with a brominating agent, such as liquid bromine or N-bromosuccinimide (NBS), under suitable reaction conditions. This reaction requires a suitable catalyst, such as iron powder or iron tribromide, to selectively introduce bromine atoms into the third position of the pyridine ring. After the bromination is completed, the nitro group is reduced to an amino group by a reducing agent, such as hydrogen and palladium-carbon catalyst system, or iron powder and hydrochloric acid system, to obtain 6-amino-3-bromo-2-methylpyridine.
Second, it can be started from 2-methylpyridine. First, nitrate 2-methylpyridine with an appropriate nitrifying agent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid, so that the nitro group is introduced into the pyridine ring. Due to the electron cloud distribution characteristics of the pyridine ring, the reaction conditions need to be carefully adjusted to achieve the substitution of nitro groups at suitable positions. Then, through the bromination step, as in the above bromination method, bromine atoms are introduced. Finally, the nitro group is converted into amino group by reduction means to achieve the synthesis of the target product.
Third, heterocyclic compounds containing pyridine structure can also be used to achieve multi-step functional group conversion. First, the starting heterocyclic compound is appropriately modified, and methyl and suitable convertible groups are introduced. Through a series of reactions, such as nucleophilic substitution, oxidation, reduction, etc., the molecular structure of 6-amino-3-bromo-2-methyl pyridine is gradually constructed. This approach requires careful design and control of the reaction conditions, reagent selection and reaction sequence in each step to effectively synthesize the target product.

6-Amino-3-bromo-2-methylpyridine is useful in medicinal chemistry, materials science, agricultural chemistry and other fields.
In the field of medicinal chemistry, because of its unique chemical structure, it can be used as a key intermediate to create new drugs. Its structural properties give it the potential to interact with specific targets in organisms, or to help develop specific drugs for specific diseases. For example, by modifying its structure, antibacterial and antiviral drugs can be developed to deal with many infectious diseases. Furthermore, it may also have important value in the research and development of anti-cancer drugs, or it can inhibit the growth and spread of cancer cells by interfering with specific metabolic pathways or signaling mechanisms of cancer cells.
In the field of materials science, 6-amino-3-bromo-2-methylpyridine can participate in the synthesis of materials with special properties. It reacts with other compounds, or can form polymers with unique electrical and optical properties. For example, in the field of organic optoelectronic materials, such polymers may be applied to the manufacture of Light Emitting Diodes (LEDs), solar cells and other devices. Due to its structure endowing the material with unique electronic transition characteristics, it may improve the photoelectric conversion efficiency of the device, optimize its luminous properties, and contribute to the development of new photoelectric devices.
In the field of agricultural chemistry, this compound also has potential applications. Or it can be used as a raw material to synthesize new pesticides, and with its special chemical activity, it can inhibit or kill crop pests and pathogens. Compared with traditional pesticides, pesticides based on 6-amino-3-bromo-2-methylpyridine may be more selective and environmentally friendly, which can not only effectively protect crops, but also reduce the negative impact on the environment and help the sustainable development of agriculture. In conclusion, 6-amino-3-bromo-2-methylpyridine has shown important application potential in many fields, and with the deepening of research, its application prospects may become broader.

6-Amino-3-bromo-2-methylpyridine is a valuable organic compound in the field of fine chemicals, which is widely used in many industries such as medicine, pesticides, and materials. However, its market price is difficult to sum up, because it is affected by the interaction of many factors.
First, the cost of raw materials bears the brunt. The price fluctuation of the starting material required for the synthesis of this compound has a great impact on the price of the final product. If the supply of raw materials is tight, or the cost rises due to factors such as market supply and demand, origin climate, and policy regulation, the price of 6-amino-3-bromo-2-methylpyridine will also rise.
Second, the complexity of the preparation process is closely related to the cost. Complex processes that require high-end technology, special equipment and harsh reaction conditions often lead to increased production costs, which in turn increases product prices. And simple, efficient and low-cost new processes, if successfully applied, may lead to lower prices.
Third, the market supply and demand situation determines the price trend. If the demand for this compound surges in fields such as pharmaceutical research and development, and the supply is relatively insufficient, the price is bound to rise; conversely, if the market demand is weak and the supply is excessive, the price may face downward pressure.
Fourth, the scale of production cannot be ignored. In large-scale production, the fixed cost per unit product is reduced due to the scale effect, and the price may be more competitive; in small-scale production, the cost is higher and the price is relatively high.
Fifth, different manufacturers set different prices due to differences in technical level, management ability, and operating costs. Well-known large factories, with advanced technology and perfect management, may be able to supply at better prices; while small factories may have higher prices due to poor cost control.
In summary, in the era of "Tiangong Kaiwu", although the price of this exact compound was not comparable, today, the price of 6-amino-3-bromo-2-methylpyridine fluctuates from tens to hundreds of yuan per kilogram. The specific price needs to be determined comprehensively according to the above factors, and it will also change in different periods and different trading scenarios.