6-(4-Morpholinyl)pyridine-3-boronic acid pinacol ester

6 - (4-morpholinyl) pyridine-3-boronic acid pinacol ester, its chemical structure can be as follows. This compound contains a pyridine ring, which is connected with a 4-morpholinyl group at the 6th position of the pyridine ring, and a boric acid pinacol ester group at the 3rd position.
The pyridine ring is a six-membered nitrogen-containing heterocycle and has aromatic properties. The nitrogen atom is hybridized with sp ² and forms a planar ring structure together with the remaining five carbon atoms. At the 6th position of the pyridine ring, the nitrogen atom is connected to a 4-morpholinyl group. The 4-morpholinyl group is a six-membered heterocyclic ring containing one oxygen atom and one nitrogen atom. The nitrogen atom is connected to the 6-position nitrogen atom of the pyridine ring and is maintained by a covalent bond.
As for the boric acid pinacol ester group connected to the 3-position of the pyridine ring, the boron atom in the boric acid part is connected to three oxygen atoms, and two of the oxygen atoms are connected to the two hydroxyl oxygen atoms of the pinacol to form a five-membered ring structure. The five-membered ring is connected to the 3-position pyridine ring by a covalent bond. In this way, the parts are connected to each other through covalent bonds to construct the overall chemical structure of the 6- (4-morpholinyl) pyridine-3-bor The properties of this structure determine that the compound may exhibit specific reactivity and properties in fields such as organic synthesis.

6- (4-morpholinyl) pyridine-3-boronic acid pinacol esters have a wide range of uses in the field of organic synthesis.
One of them is often used as a key intermediate in the construction of complex pyridine compounds. Due to its structure, the combination of pyridine ring with borate ester and morpholinyl gives it unique reactivity. The borate ester part can participate in the coupling reaction of Suzuki, which is a classic method for constructing carbon-carbon bonds. By combining with halogenated aromatics or halogenated alkenes and other substrates, under the action of palladium catalysts and bases, biaryl or alkenylated pyridine products can be efficiently generated, which is of great significance for the synthesis of molecules with specific structures and functions in medicinal chemistry and materials science.
Second, in the field of drug research and development, the compound can regulate the lipophilicity, water solubility and interaction with biological targets due to the presence of morpholine groups. Pyridine derivatives constructed on this basis may have potential biological activities, such as kinase inhibitors, receptor antagonists, etc., laying the foundation for the creation of new drugs.
Third, in the field of material synthesis, materials with specific photoelectric properties can be prepared through the organic synthesis reaction in which it participates. The conjugated system constructed by the Suzuki coupling reaction may make the obtained materials exhibit good fluorescence, electrical conductivity and other characteristics, and play a role in the development of organic Light Emitting Diodes, solar cells and other materials.
Fourth, in the study of organic synthesis methodologies, 6- (4-morpholinyl) pyridine-3-boronic acid pinacol esters are often used as model substrates to explore new reaction conditions and new catalyst systems, and to promote the development of organic synthesis chemistry. Due to its structural characteristics, it can provide a lot of information for the study of reaction mechanism, helping researchers to deeply understand the reaction process and optimize the reaction path.

The method for synthesizing 6- (4-morpholino) pyridine-3-boronic acid pinacol ester is as follows:
The starting material is selected from 6-halogenated pyridine-3-boronic acid pinacol ester and morpholine, and the two are reacted in a suitable reaction system.
First, the reaction vessel is fully replaced with nitrogen gas to remove the air in it to prevent the reactants and intermediates from being oxidized. Add 6-halopyridine-3-boronic acid pinacol ester, morpholine and an appropriate amount of organic solvents, such as N, N-dimethylformamide (DMF), toluene or dioxane, to the reaction vessel according to a certain proportion. Such organic solvents have good solubility to the reactants and can make the reaction proceed homogeneously.
Add an appropriate amount of alkali, such as potassium carbonate, sodium carbonate or potassium tert-butoxide, etc. The alkali can promote the reaction and plays a key role in the system. The amount of alkali needs to be precisely controlled. If it is too small, the reaction will be slow, and if it is too much or side reactions will occur. < Br >
The reaction system is stirred at a suitable temperature. The temperature varies depending on the selected starting material and reaction conditions, usually between 80-120 ° C. If the temperature is too low, the reaction rate is slow, and the yield of the product is low; if the temperature is too high, the side reactions will increase, which also affects the purity and yield of the product.
The reaction process is monitored by thin layer chromatography (TLC) or high performance liquid chromatography (HPLC). When the raw material point disappears or reaches the expected reaction degree, the reaction is terminated. The reaction liquid is cooled to room temperature and then post-treated.
When post-processing, the reaction liquid is first poured into an appropriate amount of water and the product is extracted with an organic solvent, such as ethyl acetate or dichloromethane. The organic phase is dried with anhydrous sodium sulfate or magnesium sulfate to remove the water in it. Then the organic solvent is removed by distillation under reduced pressure to obtain a crude product.
The crude product is purified by column chromatography or recrystallization, and pure 6- (4-morpholino) pyridine-3-boronic acid pinacol ester can be obtained. During column chromatography, the appropriate eluent is selected, which is determined according to the polarity of the product; for recrystallization, the solvent with large differences in the solubility of the product with temperature is selected.

6 - (4 -morpholinyl) pyridine-3 -boronic acid pinacol ester is a very important compound in the field of organic synthesis. Its physical properties are unique and are hereby described in detail by you.
Looking at its properties, it is mostly white to white solid powder under normal conditions. This form is conducive to storage and use, and in many chemical reaction systems, the powdered substance is more easily dispersed, thereby promoting the reaction.
When it comes to the melting point, the melting point of this compound is within a certain range (the specific value varies slightly due to the synthesis method and purity). The determination of the melting point can provide an important basis for the identification of its purity, and it is also helpful for the prediction of its behavior under heating reaction conditions. If the melting point is consistent with the theoretical value and the melting range is narrow, it indicates that the compound has high purity.
In terms of solubility, 6- (4-morpholino) pyridine-3-boronic acid pinacol ester exhibits different solubility characteristics in common organic solvents. It has good solubility in halogenated hydrocarbon solvents such as dichloromethane and chloroform. This is because the molecular structure of the compound is compatible with the intermolecular forces of halogenated hydrocarbons, which can achieve good mutual solubility. It can also be dissolved to a certain extent in organic solvents such as tetrahydrofuran, N, N-dimethylformamide. In water, its solubility is relatively poor, due to the large proportion of hydrophobic groups in its molecular structure, which makes it difficult to form effective interactions with water molecules.
In addition, the stability of this compound is also one of the important physical properties. In a normal temperature, dry and dark environment, it can maintain a relatively stable state. However, if exposed to humid air or strong light, it may decompose or deteriorate to a certain extent. Therefore, it should be properly sealed and placed in a cool and dry place when storing.
The density also has a certain value. Although in general chemical operations, the consideration of density may not be as frequent as melting point and solubility, but in specific chemical production or precise experimental design, density data also plays an indispensable role, which can provide parameter support for the accurate construction of material ratio and reaction system.
In summary, the physical properties of 6- (4-morpholino) pyridine-3-boronic acid pinacol esters are of great significance for their application in organic synthesis and related fields. Synthesizers need to be familiar with and make good use of them in order to achieve twice the result with half the effort.

The market price of 6 - (4 -morpholinyl) pyridine-3 -boronic acid pinacol ester is difficult to determine. The price often varies due to various reasons, such as the place of origin, the quality of the product, the situation of demand and supply, and the amount of purchase.
Looking at the market conditions in the past, the price fluctuates quite a lot. When there are many producers and supply exceeds demand, the price may decline; when raw materials are rare, the manufacturing process is complicated, and the demand is booming, the price is easy to rise.
If the purchase quantity is small, it is only for experimental research, and the price per gram may reach tens to hundreds of gold. Due to small transactions, the cost of a single product is high, including packaging and shipping costs. However, if it is required for industrial mass production and the batch is large, the price per gram may be reduced to several gold to tens of gold. Due to the large quantity, the unit cost can be reduced, and the home is competing for the market, and the price is often favorable.
In addition, the price of goods from different origins is also different. Famous factories are refined, with strict quality control, and the quality is high and the price is high; small factories offer slightly cheaper prices, but the quality may vary. In order to know the exact price, you need to consult the supplier in detail, compare the offer, and review the quality, quantity, and after-sales matters before you can get the right price.