6-(1H-imidazol-1-yl)pyridine-3-carboxylic acid

This is the chemical structure analysis of 6- (1H-imidazole-1-yl) pyridine-3-carboxylic acid.
Looking at its name, it can be seen that this compound is composed of two parts of pyridine and imidazole. The pyridine ring is a six-membered nitrogen-containing heterocycle in which the nitrogen atom occupies a specific position. The 3-position of the pyridine ring is connected to the carboxyl group, which is a functional group formed by the connection of carbonyl and hydroxyl groups and is acidic. The 6-position of pyridine is connected to 1H-imidazole-1-group. 1H-imidazole is a five-membered heterocycle containing two nitrogen atoms, and the 1-position nitrogen atom is connected to the 6-position of pyridine, thus constructing this complex organic compound structure.
This structure makes the compound have the characteristics of both pyridine and imidazole. Due to the existence of different functional groups, it may have unique physical and chemical properties, and may have potential application value in organic synthesis, medicinal chemistry and other fields. For example, carboxyl groups can participate in reactions such as salt formation and esterification, while nitrogen atoms on the imidazole ring and the pyridine ring can provide electron pairs, participate in coordination and other functions, or affect their interaction with biological targets, which can be used in drug development or as active groups to design new drugs.

6- (1H-imidazole-1-yl) pyridine-3-carboxylic acid, this is an organic compound that has important uses in many fields.
First, in the field of medicinal chemistry, this compound is often used as a key intermediate. The structural unit of gemimidazole and pyridine is quite common in many drug molecules and can give drugs specific biological activities. By modifying and modifying its structure, chemists can create drugs with different pharmacological properties, such as the development of antibacterial, anti-inflammatory, anti-tumor and other drugs. This compound may play an important role in helping researchers build a molecular framework with potential medicinal value.
Second, in the field of materials science, 6- (1H-imidazole-1-yl) pyridine-3-carboxylic acids also have their uses. Due to its special structure, it may participate in material synthesis and construct new materials with specific properties. For example, it may be able to coordinate with metal ions to prepare metal-organic framework materials (MOFs). Such materials exhibit excellent properties in gas adsorption and separation, catalysis, etc., so this compound can be used as a basic raw material for the construction of such high-performance materials.
Furthermore, in the field of organic synthesis chemistry, this compound can be used as a multifunctional synthetic building block. The imidazolyl and pyridine-3-carboxylic acid parts in its structure can participate in various organic reactions, such as nucleophilic substitution, coupling reactions, etc. Chemists can use it as a starting material to design reaction routes to construct complex and diverse organic molecules, providing rich options for the development of organic synthetic chemistry.
In summary, 6- (1H-imidazole-1-yl) pyridine-3-carboxylic acids play an important role in drug research and development, material preparation and organic synthesis, and promote the continuous progress and development of related fields.

To prepare 6- (1H-imidazole-1-yl) pyridine-3-carboxylic acid, there are many methods, and the following are common synthesis paths.
First, it can be started from pyridine derivatives. Using suitable pyridine halides as raw materials, it undergoes nucleophilic substitution with imidazole in the presence of bases. For example, 3-halogenated pyridine is selected, and imidazole is added to potassium carbonate and other basic agents and suitable organic solvents (such as N, N-dimethylformamide), heated and stirred, the halogen atom can be replaced by imidazolyl, and then the precursor of the target product can be obtained. Subsequent carboxylation reaction, such as the use of carbon dioxide and metal-organic reagents (such as Grignard's reagent), the carboxyl group is introduced, and the final 6 - (1H-imidazole-1-yl) pyridine-3-carboxylic acid is obtained.
Second, starting from imidazole derivatives. Appropriately modify imidazole to have an active check point for linking to the pyridine ring. For example, imidazole derivatives containing leavable groups are prepared first, and then with pyridine boronic acid or its esters, according to the Suzuki coupling reaction method, under the catalysis of palladium catalyst and base, the connection of imidazole to the pyridine ring is realized. Then carboxyl groups are introduced through specific reactions, such as hydrolysis of ester groups or oxidized aldehyde groups, to achieve the synthesis target.
Third, a cyclization strategy is adopted. A linear compound containing pyridine and imidazole structural fragments is used as a substrate, and the target molecule is constructed by intramolecular cyclization reaction. For example, a chain compound containing suitable functional groups is designed. Under the action of acid, base or metal catalyst, a molecular inner ring is formed to form a pyridine-imidazole conjugate structure, and then the obtained product is carboxylated to obtain 6- (1H-imidazole-1-yl) pyridine-3-carboxylic acid.
All synthetic methods have their own advantages and disadvantages, and careful choices are required based on factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the target product.

6- (1H-imidazole-1-yl) pyridine-3-carboxylic acid, this is an organic compound. Its physical and chemical properties are as follows:
Looking at its appearance, under room temperature and pressure, it is mostly white to light yellow solid powder. This form is conducive to storage and transportation, and is also convenient for subsequent experimental operations.
On solubility, the compound exhibits good solubility in organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF). This property makes it easy to disperse in the reaction system in organic synthesis reactions, promoting the reaction to proceed fully. However, its solubility in water is poor, which also limits its application in some aqueous systems.
The melting point has been accurately determined to be between 200-220 ° C. As an important physical property, the melting point can be used to identify the purity of compounds. If the melting point deviates from this range, or the melting range becomes wider, it often indicates that the purity of the compound is questionable.
In terms of chemical stability, 6- (1H-imidazole-1-yl) pyridine-3-carboxylic acid is quite stable under conventional conditions and can be stored for a long time without significant deterioration. However, in the environment of strong acids and bases, the imidazolyl and pyridine rings in its structure may be affected, triggering chemical reactions and leading to structural changes. This property warns that when storing and using, it is necessary to avoid contact with strong acids and bases.
In addition, the compound has a certain acidity, because its structure contains carboxyl groups, it can release protons under appropriate conditions. This acidic property allows it to neutralize with bases. In the fields of organic synthesis and medicinal chemistry, new chemical bonds may be constructed with this property, which can be used to prepare compounds with specific functions.

There is a definite price of 6- (1H-imidazole-1-yl) pyridine-3-carboxylic acid in the market. However, if you want to know its price, you can explore it through various channels.
First, in the market of chemical raw materials trading, if there is a seller of this acid, you should ask all merchants. The prices of various merchants in the market vary, depending on the quality and quantity of the goods, and the needs of buyers. Second, those who entrust chemical materials brokers are familiar with the market, can inquire about the prices of various sources, and can compare the goods and prices in different places to obtain the best. Third, on chemical-related website platforms, such as chemical product trading networks, there may be quotations for this acid. Such platforms have multiple merchants, often showing product specifications and prices, but their prices may change from time to time.
Or this acid is not a large and common product, and it is difficult to find its price. If it is an acid for special purposes and rare production, the price must be high, or it is only available in specific channels, and its price varies due to supply, demand and preparation difficulties. In short, in order to determine the market price of 6- (1H-imidazole-1-yl) pyridine-3-carboxylic acid, it is necessary to explore many parties and compare the quotations to get a near-real price.