6-(1-Pyrrolidinyl)pyridine-3-carboxaldehyde

6 - (1-pyrrolidinyl) pyridine-3-formaldehyde, this compound has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate and can be used to create a variety of drugs. The coexistence of Gain pyrrolidinyl and pyridine structures endows molecules with unique physicochemical and biological activities, and can interact with specific targets in organisms. For example, in the development of some anti-cancer drugs, the design of their structural characteristics can optimize the affinity and selectivity of drugs to cancer cells, improve efficacy and reduce damage to normal cells.
In the field of materials science, it may participate in the synthesis of new organic materials. The rigidity of the pyridine ring and the flexibility of the pyrrolidinyl group combine to give the material special electrical, optical or mechanical properties. For example, when preparing organic Light Emitting Diode (OLED) materials, the use of this compound can adjust the luminous efficiency and color purity of the material, and improve the display performance.
In organic synthetic chemistry, it is used as a multifunctional synthetic block. With the reactivity of aldehyde groups with pyrrolidinyl and pyridine rings, complex compound structures can be constructed by many organic reactions, and the diversity of organic molecules can be expanded, laying the foundation for the synthesis of new natural product analogs or functional molecules, and promoting the progress and development of organic synthetic chemistry.

6 - (1-pyrrolidinyl) pyridine-3-formaldehyde is one of the organic compounds. Its physical properties are quite impressive.
First of all, its appearance, under normal temperature and pressure, is mostly solid state, its shape or crystalline, the texture is relatively fine, and it looks shiny, like fine crystal jade.
As for the melting point, the value of the melting point, under specific conditions, has its own fixed number. The level of this melting point depends on the strength of the intermolecular force. In its molecular structure, the interaction between the pyridine ring and the pyrrolidinyl group, together with the characteristics of the aldehyde group, jointly affect its melting point. The boiling point state needs to reach a certain temperature, so that the molecules can break free from each other and change from liquid to gaseous state. The boiling point of this compound is also affected by the structure and intermolecular forces.
In terms of solubility, in organic solvents, it exhibits certain solubility characteristics. Such as common organic solvents such as ethanol and ether, it has good solubility with them. Because of its molecular structure, there are both non-polar parts of pyridine ring and pyrrolidine group, and polar parts of aldehyde group, so it can be moderately dissolved in both polar and non-polar organic solvents. In water, because of its limited polarity, the degree of solubility is relatively small.
Density is also one of the physical properties. The density of this compound may be different from that of water. The size of its density is determined by the mass and density of the molecules. The compactness of the molecular structure, the variety and number of atoms all affect the density.
In addition, its refractive index is also an important physical property. The refractive index reflects the degree of refraction of light when passing through the substance, which is related to the molecular structure and the distribution of electron clouds. The unique structure of this compound gives its refractive index a specific value, which can be an important basis for the identification and analysis of this substance.
In summary, the physical properties of 6 - (1 - pyrrolidinyl) pyridine - 3 - formaldehyde, derived from its molecular structure, are related to each other, and are of great significance in chemical research and application fields.

There are three ways to prepare 6- (1-pyrrolidinyl) pyridine-3-formaldehyde. First, pyridine-3-formaldehyde is used as the beginning, halogenated pyridine-3-formaldehyde is obtained, and then nucleophilic substitution with pyrrolidine is obtained. This reaction requires a temperature-controlled reaction in a suitable base and solvent, but the selectivity of the halogenation reaction is poor or the side reaction is unfavorable. Second, with 6-halopyridine-3-formaldehyde and pyrrolidine nucleophilic substitution, 6-halopyridine-3-formaldehyde can be prepared from pyridine through multiple steps, first halogenated at a specific position of pyridine, and then introduced into the aldehyde group at the 3-position. This route is long, the steps are cumbersome, and the total yield may be affected. Third, through palladium-catalyzed coupling reaction, suitable pyridine borate or halopyridine is reacted with pyrrolidine-containing halides or borates in the presence of palladium catalyst, ligand and base. The method has mild conditions, good selectivity, and high yield. Only the cost of palladium catalyst is high, and the post-reaction treatment may be complicated. In summary, each method has advantages and disadvantages, and the appropriate method should be selected according to the availability of raw materials, cost, yield and purity.

6 - (1-pyrrolidinyl) pyridine-3-formaldehyde, when storing, be sure to pay attention to many matters. This is an organic compound with unique properties, and the method of preservation is related to its quality and safety.
First, when protected from light. Under light, this compound may undergo photochemical reactions, causing its structure to mutate and damaging its original characteristics. Therefore, it should be stored in a dark room or in a light-shielding container.
Second, temperature is also critical. High temperature can accelerate its reaction rate and accelerate decomposition and deterioration; low temperature or cause it to crystallize, affecting access and properties. Generally speaking, it is better to store in a cool place, at 15 ° C - 25 ° C.
Third, the humidity should not be underestimated. Humid environment can easily make the compound absorb moisture, or cause reactions such as hydrolysis. It is necessary to ensure that the storage place is dry, and a desiccant can be placed in the storage place to maintain a dry environment.
Fourth, storage containers are also exquisite. Containers with good corrosion resistance and sealing must be used. Because the compound may react with certain materials, containers made of glass or specific plastic materials are more suitable, and are well sealed to prevent its volatilization and contact with external substances.
Fifth, this compound may be toxic and irritating. The storage place should be kept away from areas with frequent human activities, and it should be clearly marked to prevent accidental touch and misuse, endangering personal safety. Overall, proper storage of 6- (1-pyrrolidinyl) pyridine-3-formaldehyde requires comprehensive consideration of factors such as light, temperature, humidity, container, and safety to ensure its quality and stability.

There is a question today, what is the market price of 6- (1-pyrrolidinyl) pyridine-3-formaldehyde. However, it is not easy to figure out its price. The market price often changes due to many factors.
First, the price of raw materials has a great impact. If the raw materials required for the production of this compound are scarce, or the price of the finished product will rise due to the weather, geographical location, personnel, etc., the price of the finished product will also rise. On the contrary, if the raw materials are sufficient and cheap, the price of the finished product may drop slightly.
Second, the difficulty of the production method is also the key. If the preparation method requires exquisite skills, expensive equipment, or multiple complicated processes, it is time-consuming and laborious, the cost is high, and the price is not cheap. If there is a simple method, it can save labor and time, and the price may be close to the people.
Third, the market supply and demand will determine the price. If the demand for this product in the fields of medicine, chemical industry, etc., and the supply is limited, the price will be high. If the demand is sluggish and the supply is excessive, the price may be lower.
Fourth, manufacturers and brands are different, and the price is also different. Well-known large factories, with their exquisite craftsmanship and high quality, may have high prices. And small factories produce, although the price may be low, the quality may vary.
To sum up, in order to determine the market price of 6- (1-pyrrolidinyl) pyridine-3-formaldehyde, it is necessary to widely investigate the raw material market, the advantages and disadvantages of production methods, changes in supply and demand, and differences in manufacturers. Only by studying in detail can we obtain a more accurate price.