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What is the chemical structure of 5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid, alpha-methyl-
This is the solution of the chemical formula "5H- [1] benzopyrane [2,3-b] pyridine-7-acetic acid, α-methyl-". I will use the ancient saying of "Tiangong Wuwu" to solve this doubt.
The formula of this transformation, 5H- [1] benzopyrane [2,3-b] pyridine-7-acetic acid, α-methyl-, which is the same, it is necessary to explain the order of each group. The benzopyrane is formed by fusing benzopyrane. Benzene has a six-element carbon solution, and pyran has an oxygen-containing six-element solution. When the two are fused, according to the order of [2,3-b], the position of the joint is determined, so that the two-element phase is dense.
As for pyridine, it also contains a six-element nitrogen. Its phenylpyran phase forms the core skeleton of this compound. For 7-acetic acid, it is in the seventh position of phenylpyran and pyridine, and the acetic acid group is formed. The acetic acid group is formed from a methyl carboxyl group, and the carboxyl group has the activity of transformation, which can be reversed.
And α-methyl -, which is represented on the α position of the acetic acid group, that is, on the carbon atom of the carboxyl phase, there is a methyl group. The alkyl group of the methyl group is also affected by the properties of the compound.
Of this, the chemical compound is composed of phenylpyran and pyridine, together with the acetic acid group α-methyl. Each group is bonded to each other to form its specific chemical group, which gives the compound its unique chemical properties and physical properties.
What are the physical properties of 5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid, alpha-methyl-
5 - [1] benzopyrano [2,3 - b] pyridine - 7 - acetic acid, α - methyl - The physical properties of this substance are as follows:
It is usually a crystalline solid with a specific melting point, but the exact value varies depending on the preparation and purity. In terms of solubility, it can have a certain solubility in organic solvents such as ethanol and dichloromethane. Because the molecular structure contains polar and non-polar parts, the polar part is conducive to its interaction with polar organic solvents, and the non-polar part also has a certain affinity in non-polar organic solvents. However, the solubility in water is relatively low, due to the strong hydrophobicity of the overall molecule.
From the appearance point of view, when pure, it may be white to off-white crystalline powder. If it contains impurities, the color may change. Its density is also an important physical property. Although the exact value is difficult to generalize, it can be estimated according to the relevant chemical structure and similar compounds, and it is probably similar to the density range of common organic compounds.
The stability of this compound also needs to be considered. Under normal environmental conditions, if it is properly preserved or has certain stability, when exposed to extreme conditions such as high temperature, strong acid, and strong base, the molecular structure may change, triggering decomposition or chemical reactions. Because its structure contains a variety of chemical bonds, the activities of each chemical bond are different under different conditions.
In terms of optical properties, due to its conjugate system or absorption under specific wavelengths of light, the absorption characteristics can be determined by spectroscopic analysis techniques such as ultraviolet-visible spectroscopy. This property not only helps qualitative identification, but also has important significance in quantitative analysis.
In summary, the physical properties of 5- [1] benzopyrano [2,3-b] pyridine-7-acetic acid, α-methyl - play a key role in its research, application and subsequent treatment.
What are the common uses of 5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid, alpha-methyl-
This is the name of a complex compound in organic chemistry, which is "α-methyl-5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid". In the field of organic synthesis, the preparation of this compound often follows a specific path.
In the past, at the beginning of organic synthesis, it was necessary to understand the structural characteristics of this compound. It has a fused ring system of benzopyran and pyridine, and is connected with acetic acid and methyl substituents at specific positions.
The first step in the preparation is often the construction of benzopyran rings. A suitable phenolic compound can be selected and an unsaturated carbonyl compound with an appropriate substituent can be condensed under acidic or basic catalysis. For example, resorcinol and α, β-unsaturated esters can be used under alkali catalysis to form an intermediate product first, and the prototype of the benzopyran ring can be constructed by intramolecular cyclization.
Then, the introduction of the pyridine ring is also the key. Or it can be reacted with the constructed benzopyran derivative by means of a nitrogen-containing heterocyclic synthesis reagent. Pyridine derivatives with suitable substituents are often used as raw materials, and nucleophilic substitution, cyclization and other reaction steps are taken to fuse the pyridine ring with the benzopyran ring.
As for the addition of the α-methyl-7-acetic acid part, it can be achieved through a carbon-carbon bond formation reaction after the construction of the benzopyrano-pyridine ring is completed. For example, the halogenated acetate is reacted with a metal-organic reagent (such as Grignard's reagent or lithium reagent), the acetate group is introduced, and then hydrolyzed and acidified to obtain the α-methyl-7-acetic acid substituent.
Each step of the reaction requires fine regulation of the reaction conditions, such as temperature, pH, reaction time, etc., to ensure that the reaction proceeds in the desired direction and improve the yield and purity of the product. And after each step of the reaction is completed, it often needs to be separated and purified, such as column chromatography, recrystallization, etc., to remove impurities and obtain a purified target product "α-methyl-5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid".
What are the synthesis methods of 5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid, alpha-methyl-
To prepare α-methyl-5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid, there are many methods, which can be obtained by combining well-known organic synthesis reactions.
The choice of starting materials is related to the difficulty and yield of the reaction. Benzopyran and pyridine derivatives with suitable substituents are often selected, because their structures are similar to the target molecules, which can reduce the reaction steps.
Nucleophilic substitution reactions can be used to introduce specific groups on benzopyran or pyridine derivatives to build the basic structure of the molecule. In this step, a suitable nucleophilic reagent and reaction conditions need to be selected. For example, under the catalysis of a base, the reaction is carried out in a suitable solvent, so that the nucleophilic reagent attacks the specific check point of the substrate and forms a new chemical bond.
Then, through oxidation or reduction reaction, the oxidation state of some functional groups in the molecule is adjusted. For example, if the hydroxyl group needs to be oxidized to a carbonyl group, a suitable oxidizing agent, such as Jones reagent, can be selected to control the reaction temperature and time, so that the reaction can be carried out accurately.
Furthermore, methyl groups are introduced through alkylation reaction. In this step, an alkylating reagent with suitable activity, such as halogenated methane, needs to be selected. Under basic conditions, the methyl group is connected to the specific position of the target molecule to form an < Br >
In the synthesis process, the control of reaction conditions is crucial. Temperature, solvent, catalyst and other factors can affect the rate and selectivity of the reaction. If the temperature is too high, side reactions may occur; the polarity of the solvent will also affect the stability of the reaction intermediates.
And after each step of the reaction, it needs to be separated and purified to remove impurities and obtain a pure product. Column chromatography, recrystallization and other methods can be used to achieve separation according to the physical and chemical properties of the product and impurities. In conclusion, the synthesis of α-methyl-5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid requires comprehensive consideration of many factors such as starting materials, reaction steps, condition control, separation and purification, and careful design of reaction routes to efficiently obtain the target product.
In which fields is 5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid, alpha-methyl-used?
I think this "5H - [1] benzopyrano [2,3 - b] pyridine - 7 - acetic acid, alpha - methyl -" is the name of the chemical substance. This substance is important in the fields of pharmaceutical research and development, organic synthesis and other fields.
In the field of pharmaceutical research and development, such compounds containing special heterocyclic structures often have unique biological activities. Or they can be used as lead compounds for researchers to deeply explore their interactions with biological targets. After structural modification and optimization, it is expected to develop new drugs to treat diseases such as inflammation and tumors. Due to its specific chemical structure, it can precisely act on specific proteins or enzymes in the body and regulate physiological and pathological processes.
In the field of organic synthesis, it is also a key intermediate. Chemists can use various organic reactions to construct more complex molecular structures. Because its structure contains multiple reaction check points, it can carry out reactions such as substitution reactions and addition reactions, thus enriching the types of organic compounds and providing a material basis for the development of materials science, medicinal chemistry and other disciplines.
In short, this substance has important value in many fields of scientific research and has made great contributions to promoting scientific progress and technological innovation.