5 Trifluoromethyl Pyridine 2 Amine
pyridine pyrrole pyrazine piperidine piperazine

5-(trifluoromethyl)pyridine -2-amine

    Specifications

    HS Code

    432890

    Chemical Formula C6H5F3N2
    Molar Mass 162.11 g/mol
    Appearance Solid (predicted)
    Solubility In Water Insoluble (predicted)
    Logp 1.77 (predicted)

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    Frequently Asked Questions

    As a leading 5-(trifluoromethyl)pyridine -2-amine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 5- (trifluoromethyl) pyridine-2-amine?
    5- (trichloromethyl) pyridine-2-aldehyde, an important organic compound, has critical uses in many fields.
    In agriculture, it can be used as a nitrification inhibitor. In soil, it can inhibit the conversion process of ammonium nitrogen to nitrate nitrogen mediated by soil microorganisms. If the nitrification in soil is excessive, the ammonium nitrogen will be converted to nitrate nitrogen too quickly, which is easy to cause nitrogen leaching, and the second will enhance the denitrification effect, so that nitrogen escapes from the atmosphere in the form of nitrogen. The addition of 5- (trichloromethyl) pyridine-2-aldehyde can slow down the conversion rate, making ammonium nitrogen more persistent in the soil for crop absorption and utilization, thereby improving nitrogen fertilizer utilization efficiency, reducing nitrogen fertilizer application amount, and reducing environmental pollution caused by nitrogen loss, such as water eutrophication.
    In the field of organic synthesis, 5- (trichloromethyl) pyridine-2-naldehyde is a key intermediate. The structure of its pyridine ring and aldehyde group gives it unique reactivity. Pyridine ring is aromatic and can participate in many reactions such as electrophilic substitution and nucleophilic substitution; aldehyde group can undergo oxidation, reduction, condensation and other reactions. By means of organic synthesis, using 5- (trichloromethyl) pyridine-2-aldehyde as the starting material, a series of organic compounds with diverse structures can be constructed, such as nitrogen-containing heterocyclic compounds prepared by condensation with amine compounds. Such compounds may exhibit biological activity in the field of medicinal chemistry or be used as functional materials in the field of materials science.
    In addition, in the field of fine chemicals, 5- (trichloromethyl) pyridine-2-aldehyde can be used to synthesize specific dyes, fragrances and other fine chemicals. With its unique molecular structure, it can endow products with specific color, odor and other characteristics to meet the market demand for high-quality, differentiated fine chemicals.
    What are the physical properties of 5- (trifluoromethyl) pyridine-2-amine?
    (Sanxiang methyl) alkyne is a peculiar chemical substance. Its physical properties are unique and there are many remarkable things.
    When it comes to morphology, under normal temperature and pressure, (Sanxiang methyl) alkyne is mostly colorless and transparent liquid, which is as clear as water, but the chemical energy it contains cannot be underestimated. Although its smell is not a pungent and unpleasant smell, it also has a unique smell, with a slightly spicy taste, like a unique warning to remind the world of its high chemical activity.
    Furthermore, the density of (Sanxiang methyl) alkyne is slightly smaller than that of common water, and it can float on the surface in water, just like oil floating on water. The two are distinct. Its boiling point is also unusual. Under specific pressure conditions, it boils at a certain temperature and converts into a gaseous state. The characteristics of this boiling point make it necessary to carefully control the temperature and pressure parameters in chemical operations such as separation and purification.
    In terms of solubility, (Sanxiang methyl) alkylene has good solubility in organic solvents, such as ethanol, ether, etc., and can be mutually soluble with it to form a uniform mixed system. However, the solubility in water is extremely poor and almost insoluble. This property also brings specific effects and considerations in chemical applications and treatments.
    Its volatility is also considerable. When placed in an open environment, it can be seen gradually evaporating and disappearing from the air in a short time. In some application scenarios, this volatility can be both an advantage and a potential safety hazard, so it needs to be treated with caution.
    As for -2-alkyne in the same category as (Sanxiang methyl) alkyne, the physical properties are also similar and different. Its form is also often liquid, but its color may be slightly darker than (Sanxiang methyl) alkyne, showing a light color. In terms of smell, compared with the spicy (Sanxiang methyl) alkyne, the smell of -2-alkyne is more pungent, with strong irritation and discomfort.
    In terms of density, -2-alkyne is slightly larger than (Sanxiang methyl) alkyne, and sinks in water. The boiling point is also higher than that of (Sanxiangmethyl) alkyne, and a higher temperature is required to boil it into a gaseous state. In terms of solubility, -2-alkyne has good solubility in organic solvents, but it is also insoluble in water. The volatilization is slightly weaker than that of (Sanxiangmethyl) alkyne, and the volatilization rate is relatively slow in the open environment. Both have their own physical properties, and they need to be treated and utilized with caution according to their characteristics in chemical research and application.
    Is the chemical property of 5- (trifluoromethyl) pyridine-2-amine stable?
    (Trimethylmethyl) alkane, its value is 5 -, and then 2 is removed, and the chemical properties of this product are determined by the phase. Such a transformation is significant, let me explain.
    (trimethylmethyl) alkane is a corner of the research. Its value of 5 -, or a certain quantification table, or the inverse proportion, or the composition content, depends on the situation and research. If you go to 2 again, this calculation is not the release vector, or the reduction amount of the reduction process, or the law of the transformation of the revealed product.
    As for the scale, the determination of its chemical properties depends on many factors. Contains steroids, pigments and other components, and the weak and functional characteristics of the molecule are all affected by its characterization. If the molecule is firm, and the functional phase is inert, the chemical resistance is determined; on the contrary, if the co-cracking is easy, the functional activity is not active, and it is easy to be transformed and reversed, and the property is not good.
    And (trimethyl) alkane is not good, or in the transformation of its phase, or for the inverse mediation, the qualitative influence of the component. Or the 5-2 transformation of (trimethyl) alkane, the change of the proportion of components in a certain chemical environment, and the inverse direction of the introduction, affect the degree of its transformation. However, in order to understand the relationship between the two, more detailed and rational analysis is needed to extract and clarify their secrets.
    What are the synthesis methods of 5- (trifluoromethyl) pyridine-2-amine?
    To prepare 5- (triethylamino) pentyl-2-alkyne, there are various ways to synthesize it.
    First, a nucleophilic substitution reaction can be used. First, take a halogenated hydrocarbon containing a suitable leaving group, such as 5-halogenated pentyl-2-alkyne, and react with triethylamine. The halogen atom of halogenated hydrocarbons has good activity. The nitrogen atom in triethylamine has a lone pair electron and has good nucleophilicity. When the two meet, the nitrogen atom nucleophilic attacks the α-carbon of halogenated hydrocarbons, and the halogen atom leaves to form 5- (triethylamino) pentyl-2-alkyne. This reaction condition is relatively mild, but the choice of halogenated hydrocarbons and the adaptation of the reaction solvent are very critical. Choose halogenated hydrocarbons with moderate activity. If the activity is too high, side reactions are prone to occur; if it is too low, the reaction rate will be delayed. The solvent also needs to be considered. Its polarity and solubility to the reactants will affect the reaction process.
    Second, the nucleophilic addition reaction of alkynes is used. First, pente-2-yne is prepared. The alkyne bond is nucleophilic and can react with suitable halogenated alkane derivatives to introduce triethylamino-containing groups. This process requires the selection of suitable catalysts and reaction conditions. For example, an appropriate amount of metal catalyst can be added to catalyze the nucleophilic addition of alkyne bonds to haloalkane derivatives, so that the reaction can occur smoothly and the target product can be formed. However, attention should be paid to controlling the reaction temperature and catalyst dosage in the reaction. Excessive temperature or excessive catalyst may lead to excessive reactions or increased side reactions.
    Third, the reaction with organometallic reagents. Prepare specific organometallic reagents to react with triethylamino and alkynyl-related precursors. Organometallic reagents have high activity and can effectively realize the construction of carbon-carbon bonds or carbon-heteroatomic bonds. However, organometallic reagents are highly reactive and require severe reaction environments. They must be operated under specific conditions such as anhydrous and anaerobic conditions to ensure the reagent's activity and controllability of the reaction.
    What is the market price of 5- (trifluoromethyl) pyridine-2-amine?
    Today, you are inquiring about the market price of (trihydroxymethyl) propane-2-naphthalene. Both are commonly used in chemical industry.
    (trihydroxymethyl) propane has a wide range of uses and is indispensable in the preparation of polyester, polyurethane, and lubricating oil additives. Its price often fluctuates due to changes in raw material costs, production processes, and market supply and demand. The price of raw materials may rise, or the cost of production processes is complicated, or the market demand is greatly increased and the supply is insufficient. On the contrary, if the raw materials are sufficient and cheap, the process is refined to reduce costs, and the market demand is flat, the price may stabilize or decline. In the past few years, the price of (trihydroxymethyl) propane fluctuated frequently. Under the interaction of market supply and demand and cost factors, the price per ton may hover between several thousand yuan and more than ten thousand yuan.
    As for naphthalene, it is also an important organic chemical raw material, which can be used to make dyes, resins, solvents, etc. The price of naphthalene is also affected by many factors. The price of related raw materials such as coal fluctuates, and the production cost of naphthalene changes. The overall rise and fall of the chemical industry also increases or decreases the demand for naphthalene, which affects the price. In the past market conditions, the price of naphthalene may range from several thousand yuan to ten thousand yuan per ton, depending on different quality and market environment.
    However, it is difficult to determine the exact price The market is constantly changing, so it is necessary to check the chemical product information platform or consult the industry merchants to obtain the latest and accurate price information.