5-(Trifluoromethyl)pyridine-2-acetic acid

The chemical properties of (trialkyl methyl) -2-acetic acid are as follows:
In this compound, due to the structure of the (trialkyl methyl) group, it is endowed with a certain steric hindrance effect. In the nucleophilic substitution reaction, the steric hindrance of the (trialkyl methyl) group will affect the reaction process. If the nucleophilic reagent approaches it, the large structure of the (trialkyl methyl) group may prevent the nucleophilic reagent from approaching the reaction center, resulting in a slow down of the reaction rate.
In terms of acidity, the compound has a certain acidity due to the presence of the carboxyl group (-COOH). However, the (trialkyl methyl) group has a power supply effect, which increases the electron cloud density on the oxygen atoms in the carboxyl group, thereby weakening the dissociation ability of the hydrogen atoms in the carboxyl group. Compared with simple carboxylic acids such as acetic acid, its acidity may be weakened.
In terms of redox reaction, the carboxyl group of this compound is relatively stable and is not easy to be oxidized by general weak oxidants. However, under the action of strong oxidants, the carboxyl group may be further oxidized to products such as carbon dioxide. However, if the (trialkyl methyl) group encounters strong oxidants and the reaction conditions are suitable, the carbon-carbon bonds and carbon-hydrogen bonds may also undergo oxidation reactions to generate corresponding alcohols, alters, ketones and other oxygen-containing compounds.
In addition, in the esterification reaction, the steric hindrance of (trialkyl methyl) groups also affects the reaction rate and equilibrium. When the alcohol is esterified with (trialkyl methyl) -2-acetic acid, the steric hindrance will make it difficult for the alcohol molecule to undergo nucleophilic addition-elimination reaction close to the carboxyl group, so more severe reaction conditions are usually required, such as raising the temperature, adding excess alcohol or using a high-efficiency catalyst, to promote the esterification reaction to proceed smoothly.

The common synthesis methods for preparing 5- (trifluoromethyl) pyridine-2-acetic acid are as follows:
First, 2-methyl-5- (trifluoromethyl) pyridine is used as the starting material. First, a halogenated reagent, such as N-bromosuccinimide (NBS), is used to bromide the methyl group in the presence of an initiator to generate 2-bromomethyl-5- (trifluoromethyl) pyridine. This step of the reaction needs to be carried out in a suitable solvent, such as carbon tetrachloride, under heating or light conditions, so that the bromine radical initiates the reaction. Then, the obtained product is reacted with cyanide reagents such as sodium cyanide or potassium cyanide to undergo nucleophilic substitution, and the bromine atom is replaced by cyanyl to generate 2-cyanomethyl-5- (trifluoromethyl) pyridine. Finally, the cyanyl group can be hydrolyzed under acidic or alkaline conditions. Dilute sulfuric acid can be used in acidic conditions, and sodium hydroxide solution can be used in alkaline conditions. After hydrolysis, 5- (trifluoromethyl) pyridine-2-acetic acid can be obtained.
Second, 5- (trifluoromethyl) pyridine-2-carboxylic acid is used as raw material. First, it is reacted with a reducing agent such as sodium borohydride in a suitable solvent such as ethanol to reduce the carboxyl group to an alcohol hydroxyl group to obtain 5- (trifluoromethyl) pyridine-2-methanol. Next, the alcohol is oxidized to an aldehyde using a suitable oxidizing agent such as manganese dioxide or potassium dichromate, which is 5- (trifluoromethyl) pyridine-2-formaldehyde. Finally, through the classic Knoevenagel condensation reaction, it is reacted with malonic acid under the catalysis of an organic base such as piperidine, and then through the decarboxylation step, 5- (trifluoromethyl) pyridine-2-acetic acid can be obtained.
Third, using suitable pyridine derivatives as raw materials, through a metal-catalyzed coupling reaction. For example, using a palladium-catalyzed cross-coupling reaction, a halogen containing trifluoromethyl is reacted with a pyridine derivative in the presence of a base and a ligand to construct a pyridine structure containing trifluoromethyl. Later, through an appropriate functional group conversion step, an acetic acid group is introduced to obtain the target product 5- (trifluoromethyl) pyridine-2-acetic acid.

For (trimethylmethyl) nonyl-2-acetic acid, its use is involved in the general field.
In the field of, this compound may have special physical activity. It is often investigated for its effect on certain diseases, or it can help research new ones. Its properties may make it act on specific biological targets, such as the physiological system of a certain person, or the disease of a specific disease, to cure or solve the effect.
In the chemical industry, (trimethylmethyl) nonyl-2-acetic acid may be used as a special additive. Because of some physicochemical properties, it may improve the quality of chemical products. For example, it can enhance the viscosity of the chemical product, make it smoother, and increase the user's perception; or increase its antioxidant properties, extend the shelf life of the chemical product, and guarantee the quality of the product.
In terms of workmanship, it may play an important role in some chemical synthesis. Chemical craftsmen can take advantage of its chemical activity to pass the reaction of various compounds. These compounds may be used in the manufacture of high-performance materials, such as special plastics, plastics, etc., to improve the mechanical properties, chemical corrosion resistance and other characteristics of the material, so as to meet the needs of different workplaces.
Furthermore, in the field, (trimethyl) nonyl-2-acetic acid may be used as a synergist. It can change the physical properties of the plant, increase the adhesion and permeability of the plant surface, improve the effects of the plant, weeding and other effects, reduce the amount of use, and reduce the impact of the environment.

I look at your question, but I am inquiring about the market price of (trihydroxymethyl) aminomethane-2-acetic acid. However, the price of such substances often varies for many reasons and is difficult to determine.
First, the supply and demand of the city are deeply affected. If there are many people who want it, but the supply is small, the price will increase; on the contrary, if the supply exceeds the demand, the price may drop. Second, the place of production is also related. Different origins have different prices due to differences in raw material costs, production processes, transportation costs, etc. Third, the quality is also related to the price. Those with high quality are often high; those with inferior quality are low or low.
According to today's normal situation, the price of (trimethylol) aminomethane-2-acetic acid is between hundreds and thousands of yuan per kilogram. However, this is only a rough figure, and it is not an exact value. For details, ask chemical product dealers, traders, or refer to the data of professional chemical product price information platforms, so that accurate prices can be obtained.

The storage of (trimethylmethyl) ketone-2-acetic acid is of paramount importance, and it should be done with caution.
The (trimethylmethyl) ketone-2-acetic acid has a special nature. Where it exists, it is suitable for a dry place. In the tidal environment, it is easy to cause its water phase to form, or change its chemical properties, or its degree. Therefore, it must be a cool place to avoid this.
And avoid direct light. Light, especially light, contains a lot of energy, and shines on (trimethylmethyl) ketone-2-acetic acid, or excites its molecules, promotes its reaction, and causes the damage of the product. It is appropriate to hide in the dark or use a shading device.
In addition, the degree should also be low. It should be stored in the dark, not high or low. High, the molecular activity increases, and it is easy to cause reactions; low, or there is a risk of condensation, and it may also affect its properties. Usually at a normal or slightly lower degree of good, with its precision.
In addition, the storage device, the quality of the material. It is better to phase (trimethyl) ketone-2-acetic acid. If it is not the phase of the device, it will increase the quality and endanger the integrity of the product.
In addition, the survival of (trimethylmethyl) ketone-2-acetic acid is indispensable for dryness, protection from light, protection from light, and good equipment.