5-(trifluoromethyl)pyridine-2(1H)-thione

The main use of (triethylamino) -2 (1H) -pyrazocarboxylic acid is in the fields of medicine, pesticides and materials science, and has significant applications.
In the field of medicine, this compound has shown a crucial effect. Due to its unique chemical structure, it is endowed with specific biological activities. Numerous studies have revealed that it can be used as an intermediate in pharmaceutical synthesis. For example, when developing anti-cancer drugs with specific targeting, (triethylamino) -2 (1H) -pyrazocarboxylic acid can act as an important starting material. After a series of fine chemical reactions, a molecular structure with precise anti-cancer activity can be constructed, which helps to overcome the major disease problem of cancer and brings hope for human health and well-being.
In the field of pesticides, this compound also occupies an important position. With its special mechanism of action against certain pests or pathogens, it can be used to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. For example, for common pests and diseases of crops, pesticides developed based on (triethylamino) -2 (1H) -pyrazocarboxylic acid can precisely act on the nervous system of pests or the cell wall synthesis process of pathogens, effectively inhibit the growth and spread of pests and diseases, ensure the healthy growth of crops, and then improve food production and stabilize the foundation of agriculture.
In the field of materials science, (triethylamino) -2 (1H) -pyrazocarboxylic acid also shows unique application value. Due to its active group that can participate in specific polymerization reactions, it can be used as a functional monomer to copolymerize with other polymers to prepare polymer materials with special properties. Such materials may have excellent thermal stability or unique optical properties, and have a wide range of application prospects in high-end fields such as aerospace and electronic devices. It promotes materials science to new heights and provides solid material support for technological innovation in various industries.

To prepare 5- (trifluoromethyl) pyridine-2 (1H) -boronic acid, there are three methods.
One is the halogenated pyridine method. First, take halogenated pyridine, such as 2-bromo-5- (trifluoromethyl) pyridine, and make it react with metal reagents, such as n-butyllithium, at low temperature to form a lithium reagent intermediate. This intermediate has high activity, and then interacts with borate esters, such as trimethyl borate, and hydrolyzes to obtain the target product 5- (trifluoromethyl) pyridine-2 (1H) -boronic acid. In this process, the low-temperature reaction can precisely control the reaction process and avoid side reactions. The selection and dosage of metal reagents and borate esters have a great impact on the yield and purity of the product.
The second is the pyridine nitrogen oxide method. Taking 5- (trifluoromethyl) pyridine nitrogen oxide as the starting material, it is first reacted with a halogenating agent and introduced into a halogen atom to obtain halogenated pyridine nitrogen oxide. Then, through a reduction reaction, the oxygen atoms on the nitrogen oxide are removed, and the halogen atoms are in a suitable position. Subsequently, as in the halogenated pyridine method, it is reacted with metal reagents and borate esters to obtain the product after hydrolysis. The multi-step reaction of this path requires fine regulation, and the reaction conditions of each step are quite different, so the target molecular structure can be effectively constructed.
The third is the palladium catalytic coupling method. Using 5- (trifluoromethyl) pyridine derivatives and boric acid derivatives as raw materials, in the presence of palladium catalyst, ligand and base are added to react in a suitable solvent. The palladium catalyst can efficiently promote the formation of carbon-boron bonds, the ligand can adjust the activity and selectivity of the catalyst, and the base participates in the regulation of the reaction process. This method has relatively mild reaction conditions and has certain particularity for the substrate. If the substrate is selected properly, the target product 5- (trifluoromethyl) pyridine-2 (1H) -boronic acid can be obtained in a higher yield.

(Trichloromethyl) benzene-2 (1H) -boronic acid, also known as m-trifluoromethylphenylboronic acid, is an important intermediate in organic synthesis. Its physical properties are as follows:
In terms of appearance, this substance is usually in the form of a white to off-white crystalline powder, which is stable at room temperature and pressure, and is easy to store and use. This property makes it easy to handle in many synthetic reactions.
When it comes to the melting point, it is about 118-122 ° C. This melting point characteristic is of great significance for the identification of its purity and the control of related reaction conditions. Because at a specific temperature, the substance changes from a solid state to a liquid state, it can be judged whether its purity is good or bad. If the purity is high, the melting point range is relatively narrow; if it contains impurities, the melting point will be reduced and the melting range will become wider.
In terms of solubility, it is slightly soluble in water, but soluble in common organic solvents, such as dichloromethane, chloroform, toluene, tetrahydrofuran, etc. This solubility allows it to choose a suitable organic solvent as the reaction medium according to the reaction requirements in the organic synthesis reaction, so as to promote the smooth progress of the reaction. For example, in some homogeneous reaction systems, organic solvents that are compatible with it can be used to ensure that the reactants are fully contacted and the reaction efficiency is improved.

(Trichloromethyl) benzene-2 (1H) -boronic acid, its chemical properties are as follows:
In this compound, the boron atom has the characteristic of electron deficiency, so that the boric acid can exhibit Lewis acidity under specific conditions. It can coordinate with electron-rich substances, such as heteroatom compounds containing nitrogen and oxygen with lone pairs of electrons, and then form stable complexes.
(trichloromethyl) benzene-2 (1H) -boric acid, as a boric acid compound, is of great significance in the field of organic synthesis. It is often used as a key intermediate and participates in the Suzuki-Miyaura coupling reaction. In this reaction, boric acid and organohalide, under the joint action of transition metal catalysts such as palladium and bases, can efficiently form carbon-carbon bonds and synthesize many organic compounds with complex structures, which are widely used in pharmaceutical chemistry, materials science and many other fields.
Because of the special group (trichloromethyl) in its structure, this compound has certain unique properties. The strong electron-absorbing effect of trichloromethyl affects the electron cloud density distribution on the benzene ring, which affects the reactivity of boric acid groups. For example, compared with ordinary alkyl-substituted boric acid, (trichloromethyl) benzene-2 (1H) -boric acid may exhibit different reaction rates and selectivity in nucleophilic substitution reactions and other processes. At the same time, the existence of trichloromethyl also makes the physical properties of the compound in some organic solvents different. In practical operation and application, appropriate reaction conditions and separation and purification methods need to be selected according to these characteristics.

There is (trichloromethyl) pyridine-2 (1H) -phosphoric acid in the market today, what is the price?
I heard that this (trichloromethyl) pyridine-2 (1H) -phosphoric acid, the market median price state, varies depending on quality, quantity and market conditions. If it is of ordinary quality, the price per gram is about ten dollars; if the quantity is large, in terms of catty, it may be hundreds of dollars per catty. However, if it is a refined high-quality product, and there are many applicants, its price will be high, or more than 100 dollars per gram, which is also unknown.
There are changes in market conditions, and the balance between supply and demand affects its price. If there are many producers and few are seeking, the price will decline; if there are few producers and many are seeking, the price will rise. Therefore, if you want to know the exact price, you must consult the merchants in the cities, depending on the supply and demand at the time, to obtain an accurate number.