5-(TRIFLUOROMETHYL)-3-AMINOPYRIDINE

Triethyl-3-hydroxypyridine has many main uses.
In the field of medicine, this compound is an important synthesis intermediate. The creation of many drugs relies on its help, which can be combined with other substances through specific chemical reactions to build molecular structures with specific pharmacological activities. For example, in the development of some cardiovascular disease treatment drugs, triethyl-3-hydroxypyridine participates in the key link. After modification and transformation, the drug can accurately act on specific targets in the cardiovascular system, or regulate blood pressure, or improve heart function, and help patients recover.
In the field of materials science, it also shows extraordinary value. Due to its unique chemical structure and properties, it can be used as a component of functional materials. For example, when preparing specific optoelectronic materials, adding this compound can effectively regulate the electrical and optical properties of the material, improve the absorption and emission efficiency of the material, and optimize the luminous performance of the device in the manufacture of organic Light Emitting Diode (OLED) devices, making the display picture clearer and more vivid.
In the field of organic synthetic chemistry, triethyl-3-hydroxypyridine is often used as a reaction reagent or catalyst. It can activate specific chemical bonds, reduce the energy barrier required for reactions, and promote the smooth progress of various organic reactions, such as nucleophilic substitution reactions, oxidation-reduction reactions, etc. With its unique electronic effect and steric hindrance effect, it guides the reaction in the expected direction, enhances the selectivity and yield of the reaction, and provides a powerful tool for organic synthesis chemists to prepare complex organic compounds, enabling the synthesis of more novel and unique organic molecules, promoting the continuous development and progress of the field of organic chemistry.

To prepare 5- (triethylamino) -3 -hydroxypyridine, the synthesis method is as follows:
First, pyridine is used as the starting material. First, pyridine undergoes nucleophilic substitution reaction with halogenated ethane under appropriate conditions. The nitrogen atom of pyridine is rich in electrons, which can attack the α-carbon of halogenated ethane and leave the halogen ions to form N-ethylpyridine salt. Subsequently, the salt is treated with a strong base to capture β-hydrogen, and the α-carbon of ethyl on nitrogen forms a double bond with the pyridine ring to obtain vinylpyridine. After that, the addition reaction of vinylpyridine and triethylamine is carried out in the presence of a specific catalyst, and the nitrogen atom of the triethylamine attacks the double bond of the vinylpyridine, thereby introducing the triethylamino group on the pyridine ring. Finally, the hydroxyl group is introduced at the 3-position of the pyridine ring by a suitable oxidation method, for example, under mild conditions with a specific oxidant, to obtain the target product 5- (triethylamino) -3-hydroxypyridine.
Second, starting from 3-hydroxypyridine. 3-hydroxypyridine is first reacted with a suitable protecting group to protect the hydroxyl group from interference in subsequent reactions. After that, the 3-hydroxypyridine of the protective hydroxyl group undergoes nucleophilic substitution reaction with the halogenated triethylamine, and the nitrogen atom of the pyridine ring attacks the α-carbon of the halogenated triethylamine to form the triethylamino-containing pyridine derivative. Finally, the protective group is removed to obtain 5- (triethylamino) -3-hydroxypyridine.
Third, a multi-step cyclization strategy is adopted. Using a suitable small molecule compound containing nitrogen, oxygen and unsaturated bonds as raw materials, through a multi-step reaction, the prototype of the pyridine ring is first constructed, and the corresponding precursor groups of triethylamino and hydroxyl are introduced at the same time. Subsequently, through cyclization reaction, the pyridine ring structure is formed, and then the precursor group is converted to finally obtain 5- (triethylamino) -3 -hydroxypyridine. This process requires precise control of the reaction conditions and reagent dosage to ensure the smooth progress and selectivity of each step of the reaction.

Trichloromethyl-3-hydroxypyridine is an organic compound. Its physical properties are quite unique.
Looking at its appearance, it is mostly white to light yellow crystalline powder under normal circumstances, with a fine texture, like fine sand made in heaven. It may have a slight luster and flicker in the sun, like a pearl dusty but difficult to hide the light.
Smell its smell, it has a weak and specific smell, not pungent and unpleasant, but also unique, just like a unique ink fragrance hidden in ancient books, which can only be detected after careful taste.
When it comes to the melting point, it is about 105-107 ° C, just like the critical point where the warm sun melts winter snow in spring. When the temperature is slightly higher, this thing quietly changes shape. It also has a unique performance in organic solvents. It has a certain solubility in common organic solvents such as methanol, ethanol, and acetone. It is like a fish entering water and naturally fuses, but the solubility in water is relatively small. It is like the relationship between oil and water, and it is difficult to be intimate.
Its density is also an important physical property, about 1.48 g/cm ³, which is not as heavy as lead and iron, but it also has its own unique weight. When you hold it in your hand, you can feel its heavy texture, as if it carries the secrets of the chemical world. These physical properties, like its unique imprint in the chemical world, help us accurately identify and use it in the complex chemical substances.

The price of commercial goods often varies depending on the type and quality of the product. As for the so-called 5- (triethyl) -3-hydroxypyridine product, the price range on the market is difficult to determine immediately.
The price of this product depends primarily on its purity. If the purity is extremely high and impurities are rare, the price will be high. However, if the purity is slightly inferior and contains some impurities, the price will be slightly reduced.
Furthermore, the supply and demand of the market is also the main reason. If there are many users, the demand will exceed the supply, and the price will increase; if there are few users, the supply will exceed the demand, and the price will drop.
The origin and production method also have an impact. < Br >
Roughly speaking, this 5- (triethyl) -3-hydroxypyridine, in ordinary times, if the purity reaches more than 90%, the price per gram may be between tens of gold and hundreds of gold; if the purity is slightly lower, about 80%, the price per gram may be around 20 gold to 50 gold. However, the market conditions change, and it is difficult to determine. Businesspeople should always observe it, and operate well by knowing the ups and downs of the price.

The storage conditions of (trihydroxymethyl) -3 -aminopyridine should be placed in a cool, dry and well-ventilated place. Due to its chemical properties, if it is exposed to high temperature and humidity, it is easy to deteriorate and damage its effectiveness.
High temperature can promote its chemical reaction rate to increase, or cause molecular structure changes, while humid gas can make the substance absorb moisture, which can lead to adverse reactions such as hydrolysis. And should avoid coexistence with strong oxidants, strong acids, strong bases and other substances to prevent violent chemical reactions and dangerous situations.
And it is necessary to keep away from fire and heat sources to ensure safety. When storing, it is also advisable to use a sealed container to prevent external moisture, air, etc. from affecting it, in order to maintain the stability of the substance and achieve the purpose of good storage.