5-Methylpyridine-2-carboxaldehyde

5 - Methylpyridine - 2 - carboxaldehyde is an organic compound containing a pyridine ring and an aldehyde group. Its methyl group is connected to the 5th position of the pyridine ring and the aldehyde group is connected to the 2nd position. This compound has special chemical properties.
First, the aldehyde group has typical reactivity. The aldehyde group can be oxidized. In case of weak oxidants such as Torun reagent (silver ammonia solution), a silver mirror reaction can occur. The aldehyde group is oxidized to a carboxyl group, and the silver element is precipitated, which is attached to the container wall like a mirror. In case of strong oxidants such as potassium permanganate, it is also oxidized to a carboxyl group. At the same time, aldehyde groups can be acetalized with alcohols under acid catalysis to form acetals. This reaction is often used to protect aldehyde groups from being unnecessarily oxidized in subsequent reactions or participating in other reactions.
Second, the pyridine ring affects its properties. The pyridine ring is weakly basic, because the nitrogen atom has a lone pair of electrons, it can accept protons. This alkalinity makes 5-Methylpyridine-2-carboxaldehyde form pyridine salts in acidic environments, changing its solubility and reactivity. The pyridine ring can undergo electrophilic substitution reaction. Because the pyridine ring is an electron-deficient aromatic ring, the electrophilic substitution reaction activity is lower than that of the benzene ring, and the substituent mainly enters the 3 position (β position). For example, under appropriate conditions, halogenation, nitrification, sulfonation and other electrophilic substitution reactions can occur.
Third, methyl can participate in the reaction. Methyl is affected by the pyridine ring and aldehyde group, and has a certain activity. Methyl can be oxidized, and under the action of specific oxidants, it can be gradually oxidized to carboxyl groups to increase molecular polarity and reaction diversity. In addition, methyl can participate in some alkylation reactions, changing molecular structures and properties.
5 - Methylpyridine - 2 - carboxaldehyde presents rich chemical properties due to the existence of aldehyde groups, pyridine rings and methyl groups. It has important application value in organic synthesis, medicinal chemistry and other fields. It can be used to construct complex organic molecular structures and prepare compounds with specific biological activities.

There are several common methods for the synthesis of 5-methylpyridine-2-formaldehyde.
First, 5-methylpyridine is used as the starting material. 5-methylpyridine can be oxidized first to convert the methyl group to a carboxyl group, and then the carboxyl group is converted to an aldehyde group by reduction. In this process, a strong oxidant can be used in the oxidation step, such as potassium permanganate, etc. Under suitable conditions, the methyl of 5-methylpyridine is oxidized to a carboxyl group to obtain 5-methylpyridine-2-carboxylic acid. Then with a specific reducing agent, such as lithium aluminum hydride, in an anhydrous and low temperature environment, the carboxyl group of 5-methylpyridine-2-carboxylic acid is reduced to an aldehyde group, and 5-methylpyridine-2-formaldehyde is finally obtained.
Second, by means of halogenation reaction. First, 5-methylpyridine is halogenated, and a halogen atom is introduced at the 2-position of the pyridine ring, and then reacted with the corresponding aldehyde through metal reagents, such as Grignard reagents. For example, 5-methylpyridine is halogenated to generate 5-methyl-2-halogenated pyridine, which is then reacted with magnesium to form Grignard reagent, and then reacted with formaldehyde to obtain 5-methylpyridine-2-formaldehyde by hydrolysis. This process needs to pay attention to the control of halogenation conditions to ensure the accurate introduction of halogen atoms into the 2-position, and the subsequent reaction with formaldehyde needs to be carefully controlled to improve the yield.
Third, through the rearrangement reaction of pyridine derivatives. The structure of 5-methylpyridine-2-formaldehyde was constructed by selecting suitable pyridine derivatives and rearranging them under specific catalysts and conditions. This method requires in-depth understanding of the rearrangement reaction mechanism and reasonable selection of catalysts and reaction conditions to achieve efficient synthesis. Due to the complexity of the rearrangement reaction, the regulation of the reaction conditions has a great impact on the selectivity and yield of the product, which needs to be carefully studied and optimized.

5-Methylpyridine-2-formaldehyde, which is used in many fields.
In the field of pharmaceutical synthesis, it is a key intermediate. It can be cleverly combined with other compounds through specific chemical reactions to prepare a variety of drugs. For example, in the creation process of some anti-tumor drugs, 5-methylpyridine-2-formaldehyde can participate in the construction of the core structure of drug molecules. With its unique chemical activity, it gives the drug the ability to precisely act on tumor cells and help solve cancer problems.
In the field of materials science, it also has important value. When synthesizing specific functional materials, it can be used as a starting material. After a series of complex reactions, materials with special optical, electrical or mechanical properties are generated. For example, when developing new optoelectronic materials, the introduction of 5-methylpyridine-2-formaldehyde can optimize the electronic transport properties of the materials, so that the materials can exhibit excellent performance in optoelectronic devices such as Light Emitting Diodes, solar cells, etc., and promote the progress of energy and display technology.
In the field of organic synthetic chemistry, it plays an indispensable role. Due to the unique combination of aldehyde and methyl pyridine in its structure, it is endowed with rich reactivity. Chemists can skillfully use it to perform various organic reactions, such as condensation reactions, addition reactions, etc., according to different reaction conditions and substrates, to synthesize organic compounds with diverse structures and functions, thus contributing to the development of organic chemistry and expanding the variety and application range of organic compounds.

5-Methylpyridine-2-formaldehyde is one of the organic compounds. Its physical properties are unique and it has important application value.
Looking at its properties, it is a colorless to light yellow liquid under normal conditions, with a special odor. Although it is not strong, it has a certain irritation. This compound is soluble in many organic solvents, such as ethanol, ether, chloroform, etc., but its solubility in water is quite low.
In terms of boiling point, it is about 190-192 ° C. This boiling point value shows that the substance needs to be relatively high temperature before it can change from liquid to gaseous state. The melting point is about - 20 ° C, which means that when the temperature is lower than this value, 5-methylpyridine-2-formaldehyde will solidify into a solid state.
The density is about 1.07 g/cm ³, which is slightly higher than that of water. This density characteristic is quite critical when it comes to mixing or separating the substance with other substances.
The refractive index is about 1.539 - 1.541, and this optical property can be used to identify and analyze the compound. Due to its relatively fixed refractive index, under certain conditions, by measuring the refractive index, the purity of the substance can be determined or whether it is 5-methylpyridine-2-formaldehyde. The physical properties of 5-methylpyridine-2-formaldehyde have a profound impact on its application in organic synthesis, medicine and chemical industry. For example, because of its solubility, it can be used as a reaction solvent or participate in organic synthesis reactions; boiling point, melting point and other properties provide a key basis for its separation and purification process.

5-Methylpyridine-2-formaldehyde, the price of this product in the market varies from time to time, and also varies with the quality and quantity and the place of sale. The difficulty of making it, the price of the materials used, and the amount of sales are all variables in the price.
Looking at the past, if the technology of making this product is simple and the materials are easy to obtain, the price may be slightly flat. However, if the process is complex and the materials are rare, the price must be raised. And its use in various industries, medicine, and chemical industry, also affects its price. The research and development of medicine, the price may be high; the need for chemical industry is flat, the price may be stable.
It has a lot to do with the supply and demand of the market. If supply exceeds demand, merchants will reduce prices to promote sales; if demand exceeds supply, prices will surge. And regional differences also have an impact. Prosperous places need more and the price is high; remote places need less and the price is low.
As for the exact number, it is difficult to determine it. For the current price, ask the merchants and chemical companies in the city, or you can get a near-real number. However, the market is ever-changing, and it may be different in an instant. Therefore, if you want to know its market price, you should ask in real time to get the current value.