5-methylpyridine-2-carbonitrile

5-Methylpyridine-2-formonitrile, this is an organic compound. Its chemical properties are unique, let me talk about them one by one.
First of all, its physical properties, under room temperature, either solid or liquid, depending on its specific crystal form and intermolecular forces. Its melting and boiling point is closely related to the molecular structure, and there are hydrogen bonds, van der Waals forces and other interactions between molecules, which make the melting and boiling points different.
In terms of chemical properties, cyanyl (-CN) is an active group and can participate in many chemical reactions. First, the hydrolysis reaction is a common reaction of cyanyl groups. Under the catalysis of acids or bases, cyanyl groups can be gradually hydrolyzed to carboxyl groups (-COOH). For example, under acidic conditions, 5-methylpyridine-2-formonitrile is first hydrolyzed to an amide, and then hydrolyzed to 5-methylpyridine-2-carboxylic acid.
Second, the cyanyl group can undergo a reduction reaction, and a suitable reducing agent, such as lithium aluminum hydride (LiAlH), can reduce the cyanyl group to an amino group (-NH2O) to generate 5-methylpyridine-2-methylamine.
Furthermore, the pyridine ring also gives the compound a unique chemical activity. The pyridine ring has a certain alkaline nature and can react with acids to form salts. At the same time, the electrophilic substitution reaction can occur on the pyridine ring. However, due to the electronegativity of the nitrogen atom, the check point of the reaction is different from the electrophilic substitution of the benzene ring. Usually, the electrophilic substitution is more likely to occur at the β position of the pyridine ring.
The methyl group (-CH 🥰) is also not inert. Under appropriate conditions, oxidation reactions can occur. For example, under the action of strong oxidants, methyl groups can be gradually oxidized to aldehyde groups, carboxyl groups, etc.
To sum up, 5-methyl pyridine-2-formonitrile has active chemical properties and can participate in various chemical reactions. It is widely used in the field of organic synthesis.

5-Methylpyridine-2-formonitrile is a kind of organic compound. Its physical properties are quite characteristic, let me tell you in detail.
Looking at its morphology, under room temperature and pressure, 5-methylpyridine-2-formonitrile is mostly colorless to light yellow liquid, and its appearance is clear, showing its pure state.
As for its smell, it often has a special aromatic charm. However, this smell is not a strong and pungent genus, but it can also be detected by people, and it has a unique odor representation of its class of compounds. < Br >
When it comes to the melting point, it is about -10 ° C. This low temperature state makes it easy to maintain a liquid shape in ordinary environments. The boiling point is roughly in the range of 230 ° C - 235 ° C. This higher boiling point indicates that the intermolecular force is strong, and more energy needs to be supplied to vaporize it.
The density of 5-methylpyridine-2-formonitrile is larger than that of water, about 1.05g/cm ³ - 1.08g/cm ³, so if it is mixed with water, it will sink to the bottom of the water. Its solubility also has characteristics. It can dissolve well in organic solvents such as ethanol, ether, acetone, etc. Due to the principle of "similar miscibility", it is compatible with the molecular structure and polarity of organic solvents; however, its solubility in water is limited, only slightly soluble, which is also caused by the difference between its molecular polarity and water.
Furthermore, the stability of 5-methylpyridine-2-formonitrile is acceptable. Under normal temperature and humidity conditions, its chemical structure is not easy to change without special chemical reaction conditions. However, it is an organic compound after all. When exposed to high temperatures, open flames, or strong oxidizing agents, there is also a risk of chemical reactions, even combustion and explosion. Therefore, it is necessary to take precautions when storing and using it.

5-Methylpyridine-2-formonitrile is one of the organic compounds. Its main uses are quite wide, and it has important applications in many fields such as chemical industry and medicine.
In the field of chemical industry, it is often the key intermediate of organic synthesis. With this as the starting material, through various chemical reactions, many organic compounds with special structures and properties can be prepared. Because of the pyridine ring and cyanyl group contained in its molecular structure, it can participate in various reactions, such as nucleophilic substitution, addition reaction, etc., to construct more complex organic molecular structures, which is of great significance in the preparation of fine chemical products.
In the field of medicine, 5-methylpyridine-2-formonitrile also plays an important role. It may be an important building block for the synthesis of new drugs. By modifying and modifying its structure, compounds with specific pharmacological activities can be developed for the treatment of diseases. For example, some drugs derived from this compound or with high selectivity for specific disease targets are expected to become effective drugs for the treatment of related diseases.
In addition, in the fields of materials science, 5-methylpyridine-2-formonitrile may also show potential uses. With the continuous progress of science and technology and the gradual deepening of research, its application prospects may be broader, or it will play an important role in more fields, contributing to the development of various industries.

There are many different methods for synthesizing 5-methylpyridine-2-formonitrile. Here is the number of common ones.
First, it can be started from a suitable pyridine derivative. If 5-methylpyridine is used as a raw material, it can be functionalized with an appropriate reagent. Halogen atoms can be introduced by halogenation reaction, such as bromine or chlorine reacting with 5-methylpyridine under specific conditions to obtain halogenated 5-methylpyridine. Then, the cyanation reaction is used to replace the halogen atom with a cyanide reagent, such as potassium cyanide or sodium cyanide, under a phase transfer catalyst or other suitable conditions, so that 5-methylpyridine-2-formonitrile can be obtained.
Second, through the construction strategy of the pyridine ring. For example, with suitable nitrogenous and carbonaceous feedstocks, a pyridine ring is constructed through a multi-step reaction and methyl and cyano are introduced. A β-dicarbonyl compound can be reacted with ammonia or a nitrogen-containing compound to form a pyridine ring skeleton. During the reaction, the reaction steps are cleverly designed to introduce methyl and cyano. For example, before or during the construction of the pyridine ring, the methyl group is introduced with a methylating agent, and then the cyanyl group is introduced by cyanylation method. This process requires fine regulation of the reaction conditions to ensure that the reaction proceeds according to the desired path.
Third, the reaction is catalyzed by transition metals. Transition metals such as palladium and nickel can catalyze specific carbon-nitrogen bond formation reactions. Pyridine derivatives containing methyl groups and halogen atoms are used as substrates to react with the cyanide source in the presence of transition metal catalysts and ligands, in a suitable solvent and reaction temperature. This method has high selectivity, can effectively synthesize 5-methylpyridine-2-formonitrile, and the reaction conditions are relatively mild, and the selectivity of substrates can also follow a specific rule. Through rational selection of substrates and catalysts, the reaction yield and selectivity can be improved.

5-Methylpyridine-2-formonitrile is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage, this substance should be placed in a cool, dry and well-ventilated place. Because it may be sensitive to heat, under high temperature, it may decompose and deteriorate, so it is essential to keep away from heat sources and fires. The temperature of the warehouse should be controlled within a suitable range, generally speaking, it should not exceed 30 ° C. And should be stored separately from oxidizing agents, acids, bases, etc. This is because its chemical properties are active, and it is easy to react with various substances, causing danger. The storage place must be clearly marked, indicating its name, nature, hazard and emergency treatment method for easy access and management.
As for transportation, there are also many details. Transportation vehicles must ensure that they are in good condition and have corresponding fire and explosion-proof facilities. When loading and unloading, the operation must be gentle to prevent package damage and leakage of 5-methylpyridine-2-formonitrile. During transportation, pay close attention to changes in temperature and humidity. In case of bad weather, such as high temperature and rainstorm, corresponding protective measures should be taken. In the event of a leak, do not panic. When evacuating the surrounding personnel quickly, isolate the leakage area. Emergency personnel need professional protective equipment and handle it properly according to established procedures.
Therefore, during the storage and transportation of 5-methylpyridine-2-formonitrile, all precautions must be strictly adhered to to to ensure safety.