5-METHYL-3-PYRIDINEBORONIC ACID

5-Methyl-3-valerynic acid, a key compound in organic synthesis, has many main uses.
First, it is used to synthesize organic materials with special structures. In the field of materials science, many organic materials with unique properties require the use of organic compounds with specific structures as basic raw materials. 5-Methyl-3-valerynic acid can participate in many reactions due to its special structure of alkynyl and carboxyl groups, resulting in the construction of organic materials with unique skeletons and properties. For example, through addition reactions with compounds containing active hydrogen, polymer materials with special optical and electrical properties can be generated, which may have applications in the field of optoelectronics, such as materials for making organic Light Emitting Diodes (OLEDs).
Second, it plays an important role in drug synthesis. The design and synthesis of drug molecules often require the introduction of specific functional groups to endow drugs with specific activities and pharmacological properties. The alkynyl and carboxyl groups of 5-methyl-3-valyne acid can be converted into other functional groups through various chemical reactions, or directly participate in cyclization and bonding reactions to construct molecular structures with biological activities. For example, using it as a raw material, drug molecules with antibacterial and anti-inflammatory activities can be synthesized through a series of reactions.
Third, it is used for the preparation of fine chemicals. In the synthesis of fine chemicals such as fragrances and dyes, 5-methyl-3-valerynic acid can be used as a key intermediate. Using it as a starting material, through carefully designed reaction routes, novel fragrances or dye molecules can be prepared. For example, by reacting with other compounds containing unsaturated bonds, compounds with unique aromas or colors can be generated, which are used in daily chemicals or printing and dyeing industries.
5-methyl-3-valerynic acid has important uses in many fields of organic synthesis due to its unique structure, and can provide basic raw materials and key intermediates for different industries.

5-Methyl-3-valerynic acid is an organic compound with unique physical properties. It is colorless to light yellow liquid and has a special smell, which is difficult for ordinary people to describe accurately. It is similar to the mixed smell of some organic reagents. It smells pungent at first, and then gets used to it. This smell is more obvious in laboratory or industrial environments, and good ventilation is required during operation.
The melting point of this substance is about -10 ° C, which means that it is liquid at room temperature and solidifies at low temperature. The boiling point is between 190 and 195 ° C. When heated to this temperature range, it will vaporize into a gas. The relative density is about 0.96 g/cm ³, which is lighter than water. If accidentally mixed with water, it will float on the water surface. 5-Methyl-3-valerynic acid is slightly soluble in water because its molecular structure contains hydrophobic methyl and alkynyl groups, and the proportion of hydrophilic carboxyl groups is limited, resulting in its low solubility in water. However, it is soluble in a variety of organic solvents, such as ethanol, ether, acetone, etc., because these organic solvents and the molecules of the substance can form similar intermolecular forces, following the principle of "similar miscibility".
In addition, 5-methyl-3-valerynic acid is volatile and will evaporate slowly at room temperature. Its steam and air can form explosive mixtures, which can cause combustion and explosion in case of open flames and high heat energy. Special attention should be paid when operating and storing. Keep away from fire and heat sources, store in a cool and ventilated place, and operate in accordance with relevant safety regulations to prevent accidents.

To prepare 5-methyl-3-valerynic acid, the following ancient methods can be used.
First, propane is used as the starting point, and it is first encountered with sodium metal to obtain sodium propane. This is because hydrogen propane is acidic and can be replaced with sodium. Sodium propane is combined with 1-bromopropane to undergo a nucleophilic substitution reaction. Sodium propane has strong nucleophilic anion, attacking alpha-carbon of 1-bromopropane, bromine ions leave to obtain 2-pentyne. After 2-pentyne is hydroborated and oxidized, borane is first added to alkyne to form alkenyl boron, and then hydrogen peroxide and sodium hydroxide are used to obtain 2-pentanone. 2-pentanone is haloformed with hypohalogenates (such as sodium hypochlorite), first halogenated to produce polyhalogenated ketones, and then the carbon-carbon bond is broken under the base to obtain carboxylic salts. After acidification, 5-methyl-3-pentynic acid is obtained.
Second, starting from acetylene, it is first combined with two equivalents of sodium metal to obtain disodium acetylene. Disodium acetylene is first combined with 1-bromopropane to obtain 1-pentyne. 1-Pentyne is then combined with sodium metal and liquid ammonia to obtain trans-1-pentene sodium intermediate, and then reacted with iodomethane to obtain 2-methyl-1-pentene. 2-methyl-1-pentene is oxidized with a hot basic potassium permanganate solution, the double bond is broken, and the carbon at both ends forms a carboxyl group. Once decarboxylated, 5-methyl-3-pentyne acid can be obtained.
Third, based on 3-pentanone, first with a strong base (such as sodium hydride), to obtain enol negative ions. The enol anion undergoes nucleophilic substitution with iodomethane, and the methyl group is at the carbonyl α-position to obtain 2-methyl-3-pentanone. 2-methyl-3-pentanone reacts with triphenylphosphine Yelide (prepared from triphenylphosphine and halogenated hydrocarbons) to obtain 5-methyl-3-pentene. 5-methyl-3-pentene is ozonated-reductive hydrolyzed, double bond broken, and then oxidized and decarboxylated to obtain 5-methyl-3-pentynic acid.
All kinds of production methods, each with its own advantages and disadvantages, must be based on the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, the high or low yield, etc., choose the best and follow it.

When storing and transporting 5-methyl-3-valerynic acid, many key matters need to be paid attention to.
When storing, the first environment should be selected. It should be placed in a cool and ventilated warehouse, away from fire and heat sources, because the substance is exposed to open flames, hot topics or the risk of combustion and explosion. The warehouse temperature should be strictly controlled, generally not exceeding 30 ° C, to prevent it from being chemically unstable due to excessive temperature. And it should be stored separately from oxidants and alkalis, and must not be mixed. It is easy to react with these substances, which will greatly increase the potential safety hazard. At the same time, the warehouse needs to be equipped with suitable materials to contain the leakage. If there is a leakage, it can be dealt with in a timely and effective manner to avoid greater harm.
When transporting, it is necessary to ensure that the packaging is complete and the loading is safe. The packaging should be in accordance with relevant standards, solid and reliable, and can withstand bumps and collisions during transportation to prevent material leakage. The transportation process should be far away from high temperature areas and densely populated places, and choose a safe route. The transportation vehicle should also be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. If there is an emergency situation on the way, it can be dealt with immediately. Drivers and escorts must undergo professional training, be familiar with the characteristics of the substance and emergency treatment methods, and pay close attention to the status of the goods during transportation. If any In addition, the transportation should also strictly follow the relevant national regulations and regulations on the transportation of hazardous chemicals to ensure the legal compliance of the whole process and ensure the safety of personnel and the environment.

Today there is 5-methyl-3-valerynic acid, what is the market price? I should carefully observe the situation to determine its price.
To observe the formation of this product, it requires a fine method, using specific materials, through multiple steps of reaction, the process is complicated, and the reagents and utensils used in the meantime are also exquisite, which all increase its cost.
Also consider its use. 5-methyl-3-valerynic acid is an important raw material in the field of pharmaceutical chemistry, making special drugs; in the genus of material science, it can be used in the manufacture of special materials. Because of its wide use and demand, many people are also seeking it.
Re-examine the state of supply and demand in the market. If there are few products, but many are required, the price will be high; if the production and supply of energy are required, the price may be stable. However, its preparation is not easy, the output is limited, and the supply is often insufficient, and the price remains high.
And the storage and transportation of this acid requires special methods according to its characteristics to prevent quality change and ensure safety, which also adds to its cost.
Overall, the price of 5-methyl-3-valerynic acid in the market is quite high, often in grams, or hundreds or even thousands of yuan per gram, which is not a cheap thing. Due to the difficulty in process, wide application, hanging supply and demand, and special storage and transportation.