5-methyl-3-hydroxypyridine

5-Methyl-3-hydroxypyridine is one of the organic compounds. It has a wide range of uses and has important applications in many fields.
First, in the field of medicine, this compound is often a key intermediate in drug synthesis. Due to its unique chemical structure, it can be converted into pharmaceutical ingredients with specific pharmacological activities through a series of chemical reactions and exquisite processes. Because the efficacy of drugs depends on the precise combination of their molecular structure and target, the chemical properties of 5-methyl-3-hydroxypyridine enable it to lay the foundation for the synthesis of drug molecules with specific structures and help develop therapeutic drugs for specific diseases.
Second, in the field of materials science, 5-methyl-3-hydroxypyridine has also attracted much attention. It can be used as an important raw material for the construction of new functional materials. For example, when preparing some materials with special optical and electrical properties, it can be introduced into the molecular structure of the material to adjust the properties of the material. This combination of different atoms and groups will endow the material with different physical and chemical properties. Through the clever use of 5-methyl-3-hydroxypyridine, the material properties can be precisely regulated to meet the special requirements of different application scenarios.
Furthermore, in the field of organic synthetic chemistry, as an important synthetic building block, it provides convenience for the construction of many complex organic molecules. Organic chemists can design and implement various synthetic routes according to their structural characteristics, and react them with other organic compounds to construct more complex and diverse organic molecular structures. This not only enriches the variety of organic compounds, but also expands the broad space for subsequent applications in various fields.
To sum up, 5-methyl-3-hydroxypyridine, with its unique chemical structure, plays an indispensable role in many important fields such as medicine, materials science, and organic synthetic chemistry, promoting research and development in various fields.

5-Methyl-3-hydroxypyridine is a kind of organic compound. Its physical properties are quite unique, let me tell them one by one.
When it comes to appearance, this compound is often in the form of a white to light yellow crystalline powder, just like finely crushed jade chips, delicate and uniform. Looking at it, the color is pure, without variegated patches, showing its pure state.
As for the melting point, the melting point of 5-methyl-3-hydroxypyridine is in a specific range, about [X] ° C. When the temperature gradually rises, the originally solid substance, like ice and snow in the warm sun, slowly melts into a liquid state, which is of great significance in the identification and purification of this substance.
Solubility is also one of its important physical properties. In common organic solvents, such as ethanol, methanol, etc., 5-methyl-3-hydroxypyridine exhibits good solubility, just like fish entering water, quickly dispersing and dissolving to form a uniform solution. However, in water, its solubility is relatively weak, only slightly soluble, just like panning for gold in sand, only a small amount can be integrated into it.
In addition, 5-methyl-3-hydroxypyridine still has a certain stability. Under conventional environmental conditions, it can be stored for a long time without significant chemical changes. However, when it encounters strong oxidizing agents, strong acids or strong bases, the stability will be affected, just like when a delicate flower encounters a violent wind and rain, it is prone to chemical reactions, resulting in changes in its own structure and properties.
In addition, its smell also has characteristics, with a weak special smell, not pungent and unpleasant smell, but a unique smell, just like the subtle aroma quietly emitted in the air, it needs to be smelled carefully to be detectable.
These are the main physical properties of 5-methyl-3-hydroxypyridine, which play a key role in many fields such as organic synthesis and medicinal chemistry, affecting its application and research.

5-Methyl-3-hydroxypyridine is also an organic compound. It has unique chemical properties and has attracted much attention in the field of organic synthesis.
On its acidity, due to the presence of hydroxyl groups, phenolic hydroxyl groups can dissociate protons, showing a certain acidity. However, compared with common inorganic strong acids, its acidity is weaker. This is because the conjugate system of the pyridine ring disperses the electron cloud density on the hydroxyl oxygen atom, weakening the binding force of oxygen on hydrogen, making it easier to release protons, but not as easy to dissociate as strong acids.
As far as alkalinity is concerned, the nitrogen atom on the pyridine ring has lone pairs of electrons and can accept protons, so it is alkaline. However, the substitution of methyl and hydroxyl groups has an impact on the electron cloud density of the pyridine ring. Methyl as a power supply group can increase the electron cloud density on the ring and enhance the alkalinity to a certain extent; while hydroxyl as an electron-absorbing group will reduce the electron cloud density of the ring and weaken the alkalinity. The interaction between the two makes the basicity of 5-methyl-3-hydroxypyridine change compared with pyridine itself.
Its nucleophilicity and electrophilicity are also worthy of investigation. The electron cloud distribution on the pyridine ring is uneven, and the electron cloud density near the nitrogen atom is high, which has a certain nucleophilicity and can react with electrophilic reagents. At the same time, due to the presence of electron-withdrawing or electron-donating groups on the ring, the electron cloud density at different positions on the ring changes, resulting in different nucleophilic or electrophilic reactivity at each position.
In addition, 5-methyl-3-hydroxypyridine can participate in a variety of organic reactions, such as substitution reactions, where hydroxyl or methyl groups can be replaced by other functional groups; it can also participate in redox reactions, where hydroxyl groups can be oxidized, or pyridine rings can be reduced under specific conditions. Its diverse chemical properties provide many possibilities for organic synthesis, and can be used to prepare various organic compounds with biological activity or special functions.

The synthesis method of 5-methyl-3-hydroxypyridine, although the ancient book "Tiangong Kaiwu" does not directly describe the synthesis of this specific compound, it contains many chemical process ideas, or can be inspired by it.
First, analogous to the method of making alkali from plant ash. Find raw materials containing pyridine structure in natural materials, or 5-methyl-3-hydroxypyridine can be obtained through specific treatment. For example, in "Tiangong Kaiwu", ash is obtained by burning plants and trees, and then lye is extracted by water. This is the idea of extracting useful ingredients from natural materials. Or plants and minerals with similar pyridine ring structures can be found in nature, and the target products can be derived from their structural skeletons through roasting, extraction and other steps. < Br >
Second, the method of imitating metal smelting. Metal smelting often goes through ore treatment, reduction and other processes to obtain pure metals. Synthesis of 5-methyl-3-hydroxypyridine or from compounds containing corresponding groups, through chemical transformation, such as substitution, oxidation, reduction and other reactions. First prepare compounds containing methyl groups and pyridine rings, and then introduce hydroxyl groups at appropriate check points. The idea of controlling reaction conditions mentioned in "Tiangong Kaiwu" can be used to precisely control temperature, time and other factors to promote the reaction to the direction of generating target products.
Third, refer to pottery and porcelain making processes. This process requires strict raw material formulations and firing conditions. When synthesizing 5-methyl-3-hydroxypyridine, the proportion of reaction raw materials can be carefully screened and the reaction environment can be precisely adjusted. If the kiln temperature is suitable for porcelain production, the reaction temperature for synthesizing the compound also needs to be suitable, or the temperature control method can be used to optimize the reaction conditions and improve the yield and purity of the product.

The price range of 5-methyl-3-hydroxypyridine in the market is difficult to determine. The price of these chemicals often varies due to various factors.
First, its purity has a great impact. If it is high-purity 5-methyl-3-hydroxypyridine, it is suitable for areas where purity is demanding in fine chemicals, pharmaceutical research and development, and its price is high. Those with less purity are mostly used for general industrial purposes, and the price is slightly lower.
Second, the supply and demand of the market is also the key. If there are many people in demand at a time, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop.
Furthermore, the source of production and manufacturing costs also affect the price. If it is shipped from a long distance, the price will be high due to the cost of transportation; if there is a good method of manufacturing locally and the cost is controllable, the price may be close to the people.
Looking at the state of the market in the past, the price of 5-methyl-3-hydroxypyridine is between tens and hundreds of yuan per kilogram. However, this is only a rough figure. The actual price should be determined according to the changes in the current market and the differences in quality. Please consult the chemical suppliers in detail to determine the number.