5-methoxypyridine-3-carbonitrile

5-Methoxypyridine-3-formonitrile is an organic compound. Its chemical properties are unique, with two important functional groups of nitrile (-CN) and methoxy (-OCH).
The nitrile group is active and can participate in many reactions. During hydrolysis, under the catalysis of acid or base, it first forms an amide, which can then be converted to carboxylic acid. If under acidic conditions, it is heated with water and gradually hydrolyzed to 5-methoxypyridine-3-carboxylic acid. The nitrile group can also be reduced and treated with a suitable reducing agent, such as lithium aluminum hydride (LiAlH), can be converted into the corresponding amine, namely 5-methoxy pyridine-3-methylamine.
Methoxy group is the donator group, which has an effect on the electron cloud density distribution of the pyridine ring. Due to the methoxy donator, the electron cloud density of the pyridine ring is relatively increased, which in turn affects the electrophilic substitution reaction activity and check point selectivity of the compound. In the electrophilic substitution reaction, the electrophilic reagents are more inclined to attack the adjacent and para-sites of the methoxy group.
In addition, the pyridine ring in 5-methoxypyridine-3-formonitrile also has a certain alkalinity, which can react with acids to form salts. This property may be used in the control of specific reaction conditions and the separation and purification of products. Its chemical properties make it a key intermediate in the field of organic synthesis, used to construct complex organic molecules with diverse structures, and has shown important value in many fields such as medicinal chemistry and materials science.

The common synthesis methods of 5-methoxypyridine-3-formonitrile are as follows.
First, the compound containing the pyridine structure is used as the starting material. For example, select a suitably substituted pyridine derivative with modifiable groups at the 3rd and 5th positions of the pyridine ring. Through a specific nucleophilic substitution reaction, the methoxy group is introduced at the 5th position. Commonly used methoxylation reagents, such as sodium methoxide, etc., under suitable reaction conditions, the methoxy negative ion of sodium methoxide attacks the active check point of the 5th position of the pyridine ring to form 5-methoxypyridine derivatives. Subsequently, for the 3-position group, the nitrile reaction is carried out, and the suitable nitrile reagent, such as potassium cyanide, cooperates with the phase transfer catalyst to promote the conversion of the 3-position to the formonitrile group, so as to obtain 5-methoxypyridine-3-formonitrile.
Second, start with the construction of the pyridine ring. Using a suitable open-chain compound as the starting material, a pyridine ring is constructed through a multi-step reaction and the desired substituent is introduced. For example, a 1,5-dicarbonyl compound is combined with ammonia or a nitrogen-containing compound under the catalysis of an acid or base to form a pyridine ring skeleton through condensation reaction. In the reaction process, the reaction sequence and conditions are cleverly designed. After the construction of the pyridine ring is completed, the methoxy group is introduced at the 5th position and the methonitrile group is introduced at the 3rd position. The 5-position halogenation of the pyridine ring can be used first, and then the methoxy group is introduced by reacting with the methoxy group. After the 3-position halogenation, the methonitrile group is introduced by reacting with the cyanide reagent.
Third, the coupling reaction catalyzed by transition metals is used. Select a substrate containing the pyridine ring with suitable leaving groups at the 5th and 3rd positions, such as 5-halogenated pyridine-3-halide. Under the action of transition metal catalysts, such as palladium catalysts, the coupling reaction occurs with methoxy sources and cyan The synthesis of 5-methoxypyridine-3-formonitrile was achieved by using methoxyborate as methoxy source and zinc cyanide as cyano source in the presence of suitable ligands and bases. This method has relatively mild conditions and high selectivity, which can effectively avoid the occurrence of some side reactions.

5-Methoxypyridine-3-formonitrile is useful in various fields. In the field of pharmaceutical creation, this compound has great potential. Due to its unique structure, it can interact with many targets in organisms. Pharmaceutical researchers often use it to make new agents, or as anti-disease drugs, such as anti-cancer and anti-inflammatory genera. Because it can be changed by chemical modification, it is suitable for different pharmacological needs.
In the field of pesticide development, 5-methoxypyridine-3-formonitrile can also be used. With it as a base, insecticides and bactericidal agents can be prepared. It can precisely act on specific parts of pests or pathogens, destroying their physiological functions, but it has little damage to crops, which is very useful for ensuring the abundance and quality of agricultural products.
Furthermore, in the field of materials science, this compound has also come to the fore. It can be used to prepare materials with special properties, such as photovoltaic materials. Because its structure contains heteroatoms such as nitrogen and oxygen, the material is endowed with unique electronic properties, or in photovoltaic devices, such as Light Emitting Diode, solar cells, etc., there is a possibility of innovation, which can help its efficiency increase and cost decrease.
In the field of organic synthesis chemistry, 5-methoxypyridine-3-formonitrile is an important intermediate. Those in organic synthesis rely on the activity of its structure and undergo various reactions, such as nucleophilic substitution, addition, etc., to produce organic molecules with more complex structures and functions, which contribute to the expansion of chemical synthesis and push it to a higher level.

I look at you and ask "what is the market price of 5-methoxypyridine-3-formonitrile". However, the price of this chemical is difficult to determine, and it varies for many reasons.
First, the trend of supply and demand is the main reason. If there are many people in the world who need this 5-methoxypyridine-3-formonitrile, and there are few producers, the price will increase; on the contrary, if the supply exceeds the demand, the price will drop. For example, if a pharmacy suddenly becomes popular, the demand for its raw material 5-methoxypyridine-3-formonitrile will increase greatly, but the manufacturer has not been able to expand its production capacity, and its price will rise.
Second, the cost of manufacturing also affects its price. This includes the cost of raw materials, labor salaries, equipment consumption and energy resources. If raw materials are rare, or labor wages rise, or equipment needs to be replaced frequently, energy prices rise, all of which make the cost high, which in turn causes the price of 5-methoxypyridine-3-formonitrile to rise.
Third, market competition should not be ignored. If there are many producers of this chemical, they will compete with each other for profits, to attract customers, or to reduce their prices. And the exclusive product, because of its monopoly position, the price can be haute couture.
Fourth, changes in the current situation and regulations of the government also have an impact on the price. Such as trade disputes or tariff increases, resulting in higher import prices; or if environmental protection decrees become stricter, manufacturers are in compliance, and investment increases, and prices also rise.
In short, the market price of 5-methoxypyridine-3-formonitrile is constantly changing due to supply and demand, cost, competition, current situation decrees and many other factors. To know the exact price, you must carefully observe the current market situation and consult manufacturers, distributors and other people in the industry.

5-Methoxypyridine-3-formonitrile is one of the organic compounds. The key to its storage is to maintain its purity and stability during storage, and not to cause deterioration.
This compound is stored in a cool place for the first time. Cover high temperature can promote its chemical transformation. If the active level of the molecule is increased, it will cause decomposition and polymerization, etc., which will damage its quality. A shady place can slow down its molecular movement and maintain its chemical properties.
It is necessary to avoid moisture. Water, a variety of chemical reaction media, 5-methoxypyridine-3-formonitrile in case of moisture, or hydrolysis, or with impurities in the wet, change its structure and properties. Therefore, it is appropriate to store in a drying place, or add a desiccant to protect it.
And keep away from fire sources and oxidants. This compound may be flammable, and it is dangerous near fire, and is prone to ignition and explosion. The oxidant can react with strong oxidation, but also damage its structure and lose its original use.
And the place where it is stored, it should be well ventilated. If the ventilation is poor, the released gas will gather, and the one will easily form an explosive mixture with the air, both of which are also harmful to people. If there is good ventilation, the air will dissipate, and the risk will be reduced and the security will be reduced.
In the choice of packaging, it should not be ignored. Airtight and corrosion-resistant utensils should be used. Airtight can be separated from air and moisture, and corrosion-resistant packaging should be protected from objects, and it should be stored for a long time without damage.
In short, when 5-methoxypyridine-3-formonitrile is stored, it needs to be stored in a cool, dry and ventilated environment, protected from fire and oxidants, and selected for packaging, so that it can be stored for a long time and the quality remains unchanged for later use.