5-Methoxypyridine-3-boronic acid pinacol ester

Ethyl 5-aminoethoxypentazole-3-carboxylate is an important chemical substance in the field of organic synthesis. Its chemical properties are unique and worth exploring.
In this compound, the amino group (\ (- NH_ {2}\)) exhibits a certain alkalinity and can react with acids to form corresponding salts. For example, in the case of hydrochloric acid, the nitrogen atom in the amino group will combine with the hydrogen ion in the hydrochloric acid to form a positively charged ammonium ion, which in turn generates ammonium salts. This property is useful in organic synthesis to form new chemical bonds or to adjust the pH of the reaction system to promote the progress of certain reactions. < Br >
Ethoxy (\ (- OCH_ {2} CH_ {3}\)) part, due to the existence of oxygen atoms, it has certain nucleophilic properties. Under suitable reaction conditions, ethoxy groups can participate in nucleophilic substitution reactions. For example, when meeting halogenated hydrocarbons, the oxygen atoms in the ethoxy group will attack the carbon atoms connected to halogens in halogenated hydrocarbons, and the halogen atoms will leave as leaving groups to form new ether compounds. This reaction plays a key role in the construction of more complex organic molecular structures. The structure of the pentazole ring gives the compound certain stability and special spatial configuration. The bonding between the carbon atom and other atoms on the pentazole ring determines the stereochemical characteristics of the molecule. This unique structure allows 5-aminoethoxy pentazole-3-ethyl carboxylate to selectively participate in some chemical reactions, providing the possibility for the synthesis of organic compounds with specific configurations.
The functional group of ethyl carboxylate (\ (- COOCH_ {2} CH_ {3}\)) has not only the generality of ester compounds, but also has unique performance due to its molecular environment. Ester groups can undergo hydrolysis reactions catalyzed by acids or bases. Under acidic conditions, the hydrolysis reaction is reversible, resulting in carboxylic acids and ethanol; under basic conditions, the hydrolysis reaction is more thorough, resulting in carboxylate and ethanol. This hydrolysis reaction can be used to introduce carboxyl functional groups in organic synthesis, or to protect carboxyl groups through reverse reactions, that is, esterification reactions, to prevent unnecessary changes in subsequent reactions.
These chemical properties of 5-aminoethoxypentazole-3-ethyl carboxylate make it widely used in organic synthesis chemistry, pharmaceutical chemistry and other fields, and can help chemists synthesize organic compounds with diverse structures and functions.

5-Aminolevulinic acid-3-carboxylic acid methyl ester is mainly used. Although it is not explicitly stated in books such as Tiangong Kaiwu, it is widely used in modern times.
First, in the field of agriculture, this compound can be used as a plant growth regulator. It can promote the germination of plant seeds, make the seeds break out earlier, and enhance the ability of plants to adapt to the environment, such as drought tolerance and salinity tolerance. And it can improve the efficiency of plant photosynthesis, increase the synthesis of chlorophyll, make the plants more lush, and the fruits are more fruitful, thereby improving the yield and quality of crops.
Second, in the field of medicine, methyl 5-aminolevulinic acid-3-carboxylate plays an important role in photodynamic therapy. It can be used as a photosensitizer to produce reactive oxygen species after being irradiated with specific wavelengths of light, which can selectively destroy diseased cells, such as tumor cells, etc., with less damage to normal cells, providing an effective way for the treatment of diseases.
Third, in the cosmetic industry, it is also used. Because of its regulatory effect on cells, it can promote skin cell metabolism, improve skin texture, reduce wrinkle formation, and enhance skin luster, and is often used in the development of high-end skin care products. In addition, in industrial production, it can be used as an intermediate in organic synthesis to synthesize a variety of compounds with special properties, providing a raw material basis for the research and development of new materials and promoting the development of the chemical industry.

To prepare 5-methoxypyridine-3-boronic acid pinacol ester, the following method can be used:
First take an appropriate amount of 5-bromo-3-methoxypyridine and place it in the reaction kettle. This compound is the starting material of the reaction, and the bromine atom in its structure is active, which is the key check point for the subsequent reaction.
Inject an appropriate amount of tetrahydrofuran into the kettle as a solvent. Tetrahydrofuran is mild in nature and can effectively dissolve the reactants, providing a uniform environment for the reaction, which is conducive to intermolecular interaction and reaction.
Then add bis (pinacol) diboron and an appropriate amount of potassium acetate. Bis (phenylphosphonyl) diboron is the boron source, which can introduce the boric acid pinacol ester group; potassium acetate is used as a base to participate in the reaction process and promote the smooth progress of the reaction.
Then, add an appropriate amount of [1,1 '-bis (diphenylphosphonyl) ferrocene] palladium dichloride (II) as a catalyst. This catalyst can significantly reduce the activation energy of the reaction, accelerate the reaction rate, and enable the reaction that was difficult to occur to proceed under relatively mild conditions.
Raise the temperature of the reaction system to about 80 ° C and keep stirring the reaction at this temperature. The appropriate temperature can provide enough energy for the molecule to cause the reaction to proceed in the desired direction. Stirring allows the reactants to be fully mixed to ensure the uniformity of the reaction.
During the reaction process, monitor the reaction progress by thin layer chromatography or other suitable analytical means. When the raw material point is basically eliminated, it indicates that the reaction has reached the expected degree.
After the reaction is completed, the reaction solution is cooled to room temperature. Then, an appropriate amount of water is added to quench the reaction, and the reaction is stopped to continue.
Next, the extraction is carried out with ethyl acetate. Ethyl acetate is not miscible with the aqueous phase and has good solubility to the product. The product can be transferred from the aqueous phase to the organic phase. After multiple extractions, the organic phases are combined.
The organic phase is dried with anhydrous sodium sulfate to remove the remaining moisture. Anhydrous sodium sulfate has strong water absorption, which can ensure the dryness of the organic phase.
Finally, the solvent is removed by reduced pressure distillation, and the product is purified by column chromatography. Column chromatography can effectively separate the product and impurities according to the polarity difference of the substance, thereby obtaining high purity 5-methoxypyridine-3-boronic acid pinacol ester.

Tri-carboxylpyridine and pentaminolevulinic acid need to be paid attention to when they exist.
First of all, the degree of resistance should not be ignored. Both of these are sensitive to the degree of sensitivity, and should be placed in the place to avoid high temperature. If the degree of resistance is high, it may cause its chemical properties to be easy, or cause the opposite of decomposition, causing its inherent nature to be lost. Therefore, the degree of stability is fixed and low in normal rooms, such as refrigerated in ice (2 to 8 degrees), which can be guaranteed.
Second time, the degree of resistance should not be ignored. In the tidal environment, it is easy to attract both. The absorption of pentaminopentanoic acid may affect its temperature and chemical activity, while the absorption of tri-carboxypyridine may also affect its temperature and chemical activity. Therefore, if it exists, it must be dry, and it can be placed aside, such as water sulfuric acid, silicon, to remove the water in the air.
In addition, light is also a major issue. These two are either sensitive to light, under light, or photochemical reaction, so that it can be changed. Therefore, it is appropriate to hold it in an opaque container, such as a brown glass bottle, and it should be kept in the dark, not in direct sunlight.
In addition, the air barrier is also important. Oxygen in the air, or its oxidation, can be changed to form. The container can be filled with inert compounds, such as nitrogen, to expel oxygen and oxidize quickly.
In addition, if the two are not stored, they should be separated and released, and they should not be mixed. Due to different compounds, their chemical properties are different, mixing or causing accidental chemical reactions, endangering safety and destroying their original properties.
For the storage of pentaminovaleric acid tri-carboxylpyridine, it is necessary to pay attention to the temperature, temperature, light temperature, empty temperature and barrier temperature, so as to properly store them without losing their effectiveness.

The price of 5-aminolevulinic acid-3-carboxylic acid ester depends on many reasons.
Both of these are useful in medicine, agriculture, chemical industry and other fields. In medicine, it can be used for photodynamic therapy, cancer treatment, skin diseases, etc.; in agriculture, it can be used as a plant growth regulator to promote plant growth and increase its stress resistance.
The price in its market is primarily related to quality. If the quality is excellent, pure and less miscellaneous, the price will be high; if the quality is second, the price will be low. Second and supply and demand. If there is more demand but less supply, the price will rise; if the supply exceeds the demand, the price will fall. Furthermore, the cost of production is also a major factor. The price of raw materials, the simplicity of the production process, energy consumption, etc., all affect the cost, and then the price. If the price of raw materials is high, the process is complex and the energy consumption is high, the price is also high.
Where it is different, the price may vary. Where the economy is developed and the demand is large, the price may be high; where the economy is less developed and the demand is less, the price may be low. And different suppliers have different pricing, or due to their own cost control, market policies, etc.
Under the current circumstances, the market price of 5-aminolevulinic acid-3-carboxylic acid ester fluctuates due to the above factors. If you want a definite price, you need to consult suppliers, market surveys, and observe real-time supply and demand, quality, etc., to get a more accurate price.