5-(methoxycarbonyl)pyridine-3-carboxylic acid

5- (methoxycarbonyl) pyridine-3-carboxylic acid, this substance is in the state of white to pale yellow crystalline powder. Its melting point is between 152-156 ° C, and this temperature range determines the transition limit of its state when heated.
In terms of solubility, it is difficult to dissolve in water, because water is a very polar solvent, and the polarity of the molecule of this substance is relatively weak. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it is soluble in organic solvents such as dichloromethane, N, N-dimethylformamide, etc. The polarity of these two types of organic solvents is moderate, and they are compatible with the intermolecular forces of the substance.
In terms of stability, this substance is quite stable under conventional conditions and can be properly stored in general temperature and humidity environments. However, it should be noted that its tolerance to strong acid and strong base environments is poor. In the case of strong acid and strong base, the ester group and carboxyl group in the molecular structure are prone to react, resulting in structural changes. For example, in strong alkali solutions, methoxycarbonyl groups may hydrolyze to form corresponding carboxylate and methanol.
Because of its structure with both pyridine ring, ester group and carboxyl group, these functional groups give it unique chemical activity, making it widely used in the field of organic synthesis. It is often used as a key intermediate in the creation of various medicines, pesticides and fine chemicals.

The synthesis method of 5- (methoxycarbonyl) pyridine-3-carboxylic acid, although not directly described in the ancient book "Tiangong Kaiwu", can now be deduced according to the general method of organic synthesis.
First, pyridine-3,5-dicarboxylic acid is used as the starting material. First, pyridine-3,5-dicarboxylic acid and methanol are co-heated under the catalysis of concentrated sulfuric acid, and the esterification reaction is carried out. In this reaction, concentrated sulfuric acid acts as the catalyst and water-absorbing agent to promote the balance to move in the direction of esterification. The purpose of heating is to speed up the reaction rate, so that the two can fully react, and 5- (methoxycarbonyl) pyridine-3-carboxylic acid methyl ester can be obtained. Then the methyl ester is treated with an aqueous solution of lithium hydroxide to undergo a hydrolysis reaction. After hydrolysis is completed, it is acidified with dilute hydrochloric acid to obtain the target product 5- (methoxycarbonyl) pyridine-3-carboxylic acid.
Second, 3-cyano-5-methylpyridine is used as the starting material. First, it is blended with methanol and an appropriate amount of bases such as sodium methoxide to convert the cyano group into methoxycarbonyl, which is a nucleophilic substitution reaction. Next, the methyl group is oxidized with a strong oxidant such as potassium permanganate to form a carboxyl group. During the reaction process, attention should be paid to the control of the reaction conditions. Potassium permanganate has strong oxidizability, and its dosage and reaction temperature should be controlled to prevent excessive oxidation from causing the product to be imp Through this series of reactions, 5- (methoxycarbonyl) pyridine-3-carboxylic acid can also be prepared.
The synthesis of each step requires detailed study of the reaction conditions, material proportions and separation and purification methods to obtain pure 5- (methoxycarbonyl) pyridine-3-carboxylic acid.

5- (methoxycarbonyl) pyridine-3-carboxylic acid, this is an organic compound. It has applications in many fields.
In the field of medicinal chemistry, it is often a key intermediate in drug synthesis. The structure of Gainpyridine and carboxylic acids gives it a variety of reactive activities, and it can be chemically modified to synthesize drug molecules with specific biological activities. For example, it can be used to develop antibacterial and anti-inflammatory drugs. By modifying its structure, the resulting drugs can more effectively act on specific targets and improve drug efficacy.
In the field of materials science, it also has important uses. It can participate in the synthesis of polymer materials and give materials special properties by virtue of its own structural characteristics. Such as preparing functional polymers, improving the solubility and thermal stability of materials, etc., for the manufacture of special plastics, coatings, etc., to improve the comprehensive properties of materials.
In the field of organic synthesis chemistry, it is an important synthetic building block. Because it contains a variety of active functional groups, more complex organic molecular structures can be constructed through a series of organic reactions. Chemists can use it for esterification, amidation and other reactions to expand the structural diversity of molecules and lay the foundation for the synthesis of new organic compounds.
In summary, 5- (methoxycarbonyl) pyridine-3-carboxylic acids play an indispensable role in the fields of medicine, materials, and organic synthesis, and promote scientific research and technological development in related fields.

I haven't heard the exact market price of "5 - (methoxycarbonyl) pyridine - 3 - carboxylic acid". This is a fine chemical, and its price often varies depending on quality, purity, supply and demand, and purchase quantity.
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To determine the purity of 5 - (methoxycarbonyl) pyridine - 3 - carboxylic acid, the following methods can be used. First, high performance liquid chromatography (HPLC) is used. This is a commonly used method, which can effectively separate the compound from impurities. First, the mobile phase is prepared, which is often mixed with water and organic solvents in a specific ratio, such as acetonitrile - water system, followed by an appropriate amount of acid or salt to adjust the pH to optimize the separation effect. Following the standard of the compound with different concentrations of standard solutions, the peak area of the injection was measured, and the standard curve was established. Then take an appropriate amount of the sample to be tested, dissolve the bandwidth evaluation and inject it into the liquid chromatograph. According to the obtained peak area, the purity is calculated according to the standard curve. < Br >
Second, gas chromatography (GC) is also feasible, but the compound needs to be volatile to a certain extent or can be volatilized after derivatization treatment. Select a suitable column, such as a capillary column, set parameters such as injection port, detector temperature and carrier gas flow rate. Similarly, a standard curve is established with the standard product, and the sample to be tested is injected and analyzed to determine the purity.
Third, melting point determination method. Pure 5 - (methoxycarbonyl) pyridine - 3 - carboxylic acid has a specific melting point range. Measure with a melting point instrument, fill the sample in the capillary and slowly heat up. If the obtained melting point is consistent with the literature value and the melting range is narrow, about 1-2 ° C, the purity is higher; if the melting range is wide and the melting point is deviated, the purity is worrying.
Fourth, elemental analysis method. By measuring the content of carbon, hydrogen, nitrogen and other elements in the compound, compare it with the theoretical value. If the deviation is small, the purity is good, and if the deviation is large, it contains more impurities. However, this method can only provide approximate purity information and is often used in combination with other methods.
This method has its own advantages and disadvantages. In practical application, according to specific needs and conditions, an appropriate method or a combination of methods should be selected to determine the purity of 5- (methoxycarbonyl) pyridine-3-carboxylic acid.