5-METHOXY-PYRIDINE-3-CARBALDEHYDE

3-Methylaminopyridine-3-methylpyridine is an important compound in organic chemistry. It has unique physical properties and is used in many fields.
Let's talk about the appearance first. The two are mostly colorless to light yellow liquids under normal conditions, with a bright color. 3-Methylaminopyridine may sometimes be white to light yellow crystalline solid, depending on specific conditions. It is relatively pure and has no obvious impurities.
When it comes to boiling point, the boiling point of 3-methylaminopyridine is about 254 ° C, and the boiling point of 3-methylaminopyridine is around 143 ° C. The reason for the difference in boiling point is that the molecular structure and interaction force of the two are different. 3-Methylaminopyridine molecules require higher energy to vaporize due to the presence of amino groups and enhanced hydrogen bonding, resulting in a higher boiling point.
In terms of melting point, the melting point of 3-methylaminopyridine is about 32-35 ° C, and the melting point of 3-methylaminopyridine is about -17.7 ° C. This is also due to different structures. The molecular regularity and interaction of 3-methylaminopyridine cause its melting point to be higher.
In terms of solubility, both have certain solubility characteristics. 3-methylaminopyridine is soluble in common organic solvents such as water, ethanol, and ether, while 3-methylaminopyridine is slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, and benzene. 3-Methylaminopyridine has better solubility in water because amino groups can form hydrogen bonds with water.
Density is also an important physical property. The density of 3-methylaminopyridine is about 1.041g/cm ³, and the density of 3-methylpyridine is about 0.956g/cm ³. The density difference is due to the difference in molecular composition and structure, which affects the state of mixing with other substances in practical application.
The volatility of the two is also different. 3-methylpyridine is relatively volatile and is more likely to disperse in the air at room temperature. This is due to the relatively weak intermolecular forces, and the molecules are more likely to escape the liquid phase.
Odor, 3-methylaminopyridine has a special ammonia smell, 3-methylaminopyridine has a strong pungent smell, pungent smell. This odor characteristic requires special attention during operation and use, because it may cause irritation to the human respiratory tract, eyes, etc.

5-Aminoacetal diethyl acetal, also known as 3-aminopropional diethyl acetal, has the following chemical properties:
This substance is alkaline because the nitrogen atom in the amino group has lone pairs of electrons, which can bind protons. In an acidic environment, amino groups easily react with hydrogen ions to form positively charged ammonium ions, which are similar to many amino-containing compounds. For example, aniline, amino groups can increase the density of the electron cloud of the phenyl ring, making it more prone to electrophilic substitution reactions. The amino group of 5-aminoacetal diethyl acetal also affects the distribution of the electron cloud of the surrounding group, or changes the activity of the carbon atoms connected to it.
From the perspective of the structure of the acetal, it is relatively stable to bases. Because acetals do not generally hydrolyze under alkaline conditions. However, in acidic conditions, the structure of acetals will be affected, and hydrolysis reactions will occur to generate alarms and alcohols. In acidic media, 5-aminoacetal diethyl acetal will partially hydrolyze and release aminoacetaldehyde. Like common acetals such as acetal diethyl acetal, it will hydrolyze back to acetaldehyde and ethanol in dilute acid, and the hydrolysis mechanism of 5-aminoacetal diethyl acetal is similar.
In addition, the amino group of 5-aminoacetal diethyl acetal can participate in a variety of reactions, such as acylation with acyl chloride or acid anhydride, and the amino hydrogen is replaced by an acyl group to form amide compounds. This reaction is often used in organic synthesis to protect amino groups or construct compounds containing amide bonds. Because of its amino and acetal structures, it can participate in some reactions to build complex organic molecules, providing various possibilities for organic synthesis. It can be used as an intermediate in organic synthesis for the preparation of drugs, bioactive molecules, etc.

5-Aminopyridine-3-formonitrile is a key intermediate in organic synthesis. The common synthesis methods are as follows:
First, 3-cyanopyridine is used as the starting material. Let 3-cyanopyridine react with suitable amination reagents under suitable reaction conditions. For example, in the presence of a strong base, it can react with ammonia sources such as liquid ammonia or organic amines. During this reaction, the strong base can activate the pyridine ring of 3-cyanopyridine, prompting the nucleophilic substitution reaction of the ammonia source, and finally achieve the synthesis of 5-aminopyridine-3-formonitrile. The advantage of this method is that the raw materials are relatively easy to obtain and the reaction route is relatively straight. However, the reaction conditions may be more stringent, and the requirements for reaction equipment are higher.
Second, the halogenation and amination of pyridine derivatives are used. First, the pyridine derivative is halogenated at a suitable position to obtain the pyridine derivative containing halogen atoms, such as the introduction of halogen atoms at the 3rd and 5th positions of the pyridine ring. Subsequently, the nucleophilic substitution reaction is used to replace the halogen atom with an amino group to synthesize 5-aminopyridine-3-formonitrile. In this method, the halogenation reaction can achieve the precise introduction of halogen atoms by selecting different halogenation reagents and reaction conditions. In the nucleophilic substitution reaction, suitable amination reagents and catalysts need to be selected to improve the yield and selectivity of the reaction. This approach has high flexibility and can achieve the conversion of different substituted pyridine derivatives by regulating the halogenation step, but the reaction steps are relatively increased and the operation is more complicated.
Third, the coupling reaction catalyzed by transition metals is used. The coupling reaction occurs under the action of transition metal catalysts. Commonly used transition metal catalysts include palladium and copper. By selecting suitable ligands and reaction solvents, the efficiency and selectivity of the reaction can be effectively improved. This method has unique advantages for constructing complex pyridine derivative structures, but the cost of catalysts is higher, and the requirements for reaction operation are also stricter. The reaction needs to be carried out under harsh conditions such as anhydrous and anoxic.

5-Aminopyridine-3-formaldehyde, also known as 3-formyl-5-aminopyridine, is used in many fields.
In the field of medicinal chemistry, its role is significant. Due to the presence of amino and aldehyde groups in its structure, it can be used as a key intermediate for the synthesis of various biologically active compounds. Such as specific antibacterial drugs, 5-aminopyridine-3-formaldehyde is skillfully used to react with other reagents through chemical synthesis to build complex molecular structures with antibacterial effects. Or in the development of anti-tumor drugs, using this as a starting material, through multi-step reactions, drug molecules that target tumor cells are created, providing a new way to overcome tumor problems.
In the field of materials science, it is also indispensable. It can participate in the preparation of functional materials, such as luminescent materials. After rational design of the reaction, 5-aminopyridine-3-formaldehyde is integrated into the polymer structure, giving the material unique optical properties, or can emit specific wavelengths of light, which can be used in display technology, sensors and other fields.
In the field of organic synthesis, 5-aminopyridine-3-formaldehyde is an extremely important building block. Due to its bifunctional properties, it can selectively react with various nucleophiles or electrophiles under different reaction conditions to realize the construction of carbon-nitrogen and carbon-carbon bonds, providing convenience for the synthesis of organic compounds with diverse structures. For example, when constructing polycyclic pyridines, they are used as key raw materials to cyclize with other compounds containing active groups, and efficiently generate complex polycyclic systems with specific functions.

Today, there is 5-aminopyridine-3-formaldehyde. What is the market price? This is an important matter that everyone is concerned about. We need to study many ways to get a more accurate answer.
The market situation, its price is often affected by many factors. The first is the cost of raw materials. The preparation of 5-aminopyridine-3-formaldehyde requires specific raw materials. If the raw materials are scarce or the price fluctuates, the cost will change, which will affect the market price. If the origin of raw materials suddenly changes, the supply of raw materials will decrease sharply, and the price will inevitably rise. The price of 5-aminopyridine-3-formaldehyde will also increase.
Furthermore, the difficulty of the preparation process is also the key. If the preparation process is complicated, the technical and equipment requirements are strict, and the manpower and material resources required are considerable, the cost is also high, and the price is naturally high. On the contrary, if the process is simple, the cost is controllable, and the price may be relatively close to the people.
The state of supply and demand in the market should not be underestimated. If there is strong demand for 5-aminopyridine-3-formaldehyde in many industries, but the supply is limited, the price will rise; if the demand is low and the supply is excessive, the price may decline. For example, in an emerging field, the demand for it increases sharply, and the supply exceeds the demand, and the price will skyrocket.
Regional differences also have an impact on the price. In different places, prices vary due to factors such as logistics, taxation, and market competition. In prosperous cities, logistics is convenient, competition is fierce, and prices may be relatively stable; in remote places, transportation costs are high, competition is small, and prices may be high.
From this perspective, the market price of 5-aminopyridine-3-formaldehyde is difficult to hide. To know its exact price, you need to pay attention to market dynamics in real time, and consider many factors such as raw materials, processes, supply and demand, and regions to make a more accurate judgment.