5-methoxy-2-methylpyridine

5-Methoxy-2-methylpyridine is one of the organic compounds. It has specific physical properties, let me tell you one by one.
Looking at its properties, it is mostly a colorless to light yellow liquid under normal conditions. At room temperature, it is like the babbling water, which is agile and smooth. Its boiling point is about 190-192 ° C. When the temperature rises to this point, it will be like a feather, turning from liquid to gaseous. The melting point is about -30 ° C. If the temperature drops to this point, it will be like falling into a deep sleep and turning from a flowing state to a solidified state.
When it comes to solubility, this compound is slightly soluble in water, just like the dragonfly, blending a little, but not completely blending; however, it is highly soluble in organic solvents, such as ethanol and ether, just like a fish entering the sea, free and miscible.
The density of 5-methoxy-2-methylpyridine is about 1.02-1.04 g/cm ³, which is slightly heavier than water. If it is placed in one place with water, it will be like a stable person, sinking below. Its refractive index is about 1.505-1.510. When light passes through it, it is like entering a labyrinth by mistake, causing wonderful refraction. < Br >
The vapor pressure at a certain temperature has a specific value, which reflects the degree of difficulty of volatilization. In a normal temperature environment, the volatilization rate is moderate, neither as fast as a wind nor as slow as a snail.
The physical properties of 5-methoxy-2-methylpyridine are of great significance in the fields of organic synthesis and drug development, providing a key basis for many scientific research and production work.

5-Methoxy-2-methylpyridine is an organic compound. It has many unique chemical properties.
This compound contains a pyridine ring, which is aromatic, stable in nature, not easy to add, and prone to electrophilic substitution. Because the nitrogen atom has lone pair electrons, the electron cloud density of the pyridine ring is unevenly distributed, and the electron cloud density of the adjacent and para-position of the nitrogen atom is relatively low, so the electrophilic substitution reaction mostly occurs in the meta-position. < Br >
The methoxy group of 5-methoxy-2-methylpyridine, as the donator group, can increase the electron cloud density of the pyridine ring, making the electrophilic substitution reaction easier to proceed, and has a positioning effect on the reaction check point, making the electrophilic reagents more inclined to attack the ortho and para-methoxy groups. Methyl is also a donator group. Although the donator ability is weaker than that of methoxy, it can also affect the electron cloud density of the pyridine ring, which affects the reaction activity and check point selectivity to a certain extent.
Under alkaline conditions, the nitrogen atom of 5-methoxy-2-methylpyridine can accept protons and exhibit alkalinity. However, due to the participation of lone pair electrons of nitrogen atoms in the pyridine ring in the conjugated system, its basicity is weaker than that of aliphatic amines.
From the perspective of redox, this compound can participate in oxidation reactions, and the side chains or substituents on the pyridine ring can be oxidized. Under the action of suitable reducing agents, the pyridine ring may also be reduced.
In addition, 5-methoxy-2-methylpyridine can form complexes with metal ions due to the presence of nitrogen atoms, methoxy groups, etc., which exhibit unique coordination chemical properties and may have potential applications in catalysis, materials science and other fields.

The common synthesis method of 5-methoxy-2-methylpyridine is an important problem in chemical synthesis. The synthesis method often follows a number of paths.
First, pyridine is used as a group, and it is obtained by methylation and methoxylation. First, the 2-position of pyridine is introduced into the methyl group with a suitable methylating agent, such as iodomethane, and catalyzed by a suitable base. Potassium carbonate is commonly used in bases, and it is reacted in organic solvents such as N, N-dimethylformamide (DMF). When the temperature is controlled at 50-80 ° C and the number of hours is passed, 2-methylpyridine can be obtained. Then, the methoxy group is introduced into the 5-position of 2-methylpyridine with a methoxylating agent, such as sodium methoxide. In this step or in a solvent such as toluene, the reaction is heated to 100-120 ° C. After a few hours, the target 5-methoxy-2-methylpyridine can be obtained.
Second, start with halogenated pyridine. First prepare 2-halogenated-5-methoxypyridine, halogenated ones, such as chlorine and bromine. Then methylation reagent, such as methyl Grignard reagent (methyl magnesium bromide, etc.), in anhydrous ether or tetrahydrofuran and other solvents, low temperature (0-20 ℃) reaction, so that the halogen atom is replaced by methyl, and finally 5-methoxy-2-methylpyridine.
Third, the method of heterocyclic ring construction. For example, small molecules containing nitrogen and oxygen are used to form pyridine rings by cyclization. Suitable compounds such as alters, ketones, amines, etc. are catalyzed by acids or bases to form rings in multiple steps, and methoxy groups and methyl groups are ingeniously introduced during the cyclization process. However, this method is more complex and requires fine control of the reaction conditions and steps.
All synthetic methods have their own advantages and disadvantages. In practical application, when considering factors such as the availability of raw materials, cost, and difficulty in controlling reaction conditions, the optimal method is selected.

5-Methoxy-2-methylpyridine is useful in various fields. In the field of medicinal chemistry, it is an important intermediate in organic synthesis. It can combine with other compounds through a specific reaction path to produce biologically active drug molecules. The unique structure of the cover gives the pharmaceutical product specific pharmacological properties, or antibacterial, antiviral, and even anti-tumor effects.
In the field of materials science, it can also be seen. Using it as a raw material, through chemical modification and polymerization, materials with special properties can be obtained. These materials may be unique in optical and electrical properties, and are expected to be used in the manufacture of new photoelectric materials, such as organic Light Emitting Diode (OLED). Due to their unique electronic structure, the color purity and luminous efficiency of OLED devices may be improved.
Furthermore, in agricultural chemistry, 5-methoxy-2-methylpyridine is also useful. It can be used as a key component of synthetic pesticides. After rational design and modification, it can be made into pesticide products with high insecticidal and bactericidal properties. It can precisely act on specific targets of pests or pathogens, ensuring a bumper crop harvest while reducing the adverse impact on the environment. It meets the development needs of modern green agriculture. In conclusion, 5-methoxy-2-methylpyridine, with its unique chemical structure, plays an important role in many fields such as medicine, materials, and agricultural chemistry, providing an important material basis for technological innovation and development in various fields.

I don't know the market price of 5-methoxy-2-methylpyridine. However, in the market, the price of various chemical materials often changes due to various reasons. First, the abundance of raw materials is different. If the raw materials required to generate this 5-methoxy-2-methylpyridine are extremely abundant at some point, the cost may drop, and the price will also fall; if the raw materials are scarce and need to be purchased at a high price, the price of the product will rise. Second, the difficulty of the process is related to the cost. If the preparation process of this compound is complicated, requires multiple processes, special equipment and superb skills, and requires huge manpower and material resources, the price will be high; if the process is simple, the cost can be reduced, and the price will also be lower. Third, the market supply and demand situation is deeply affected. If the market has a strong demand for this 5-methoxy-2-methylpyridine, but the supply is limited, the so-called rare goods are more expensive, and the price will rise; if the supply exceeds the demand, the merchants will sell their goods or compete to reduce the price. And different merchants have different prices due to their own operating costs and profit considerations. Or there are large merchants, with the advantage of scale, good cost control, and their prices may be more affordable; while small merchants have higher costs, and their prices may be slightly higher. Therefore, if you want to know the exact price, you should consult the chemical material supplier or check the price list of the chemical product trading platform to get a near-real value.