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What is the chemical structure of 5-Methoxy-2- {[ (4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl} -1H-imidazo [4,5-b] pyridine?
5-Methoxy-2-{ [ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} -1H-imidazolo [4,5-b] pyridine, this is an organic compound. To know its chemical structure, let me tell you in detail.
Among this compound, imidazolo [4,5-b] pyridine is its core skeleton. This skeleton is formed by fusing imidazole ring with pyridine ring, forming a unique ring structure, endowing the compound with specific chemical properties and spatial configuration.
In the 2-position of the imidazolo [4,5-b] pyridine skeleton, a special substituent {[ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} is connected. In this substituent, the sulfinyl group (-SO-) is the key connecting part, one end is connected to the 2-position of imidazolo [4,5-b] pyridine, and the other end is connected to the [ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] part.
and the [ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] part, in which the 3,5-positions of the pyridine ring each have a methyl (-CH) substitution, and the 4-position has a methoxy (-OCH) substitution. The 2-position of the pyridine ring is connected to the sulfinyl group through methylene (-CH ² -) to form this complex substituent.
In addition, at the 5-position of the imidazolo [4,5-b] pyridine skeleton, a methoxy group (-OCH) is connected. The presence of this methoxy group also has a certain impact on the properties of the compound.
In this way, the chemical structure of 5-methoxy-2-{ [ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} -1H-imidazolo [4,5-b] pyridine is clarified, and the parts are connected and interacted with each other, giving this compound unique chemical and physical properties.
What is the main use of 5-Methoxy-2- {[ (4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl} -1H-imidazo [4,5-b] pyridine?
5-Methoxy-2-{ [ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} -1H-imidazolo [4,5-b] pyridine, which is a compound in the field of medicinal chemistry. Its main use is in the field of medicine, and it is a key component of proton pump inhibitors.
Guanfu proton pump inhibitors can effectively inhibit gastric acid secretion. The proton pump of gastric parietal cells is a key link in gastric acid secretion. This compound can specifically act on the proton pump, and by closely combining with the specific check point of the proton pump, its activity is lost, thereby significantly reducing gastric acid secretion. In this way, it is effective in the treatment of many gastric acid-related diseases, such as gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
In the treatment of gastric ulcer, it can create a suitable gastric environment and help the repair and healing of the ulcer surface; in the treatment of reflux esophagitis, it can reduce the irritation and damage of gastric acid to the esophageal mucosa, relieve heartburn, acid reflux and other uncomfortable symptoms. Due to its long-lasting and efficient acid suppression effect, it has brought good news to many patients with gastric acid-related diseases and improved their quality of life, playing an important role in modern medical clinical treatment.
What are the synthesis methods of 5-Methoxy-2- {[ (4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl} -1H-imidazo [4,5-b] pyridine?
5-Methoxy-2-{ [ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} -1H-imidazolo [4,5-b] pyridine, this is a complex organic compound. The method of synthesis is always an important matter in organic synthesis.
Synthesize this compound in the past, or take 4-methoxy-3,5-dimethyl-2-pyridyl methyl halide first, react with thiol salt to obtain thioether. After careful oxidation with a suitable oxidizing agent, such as m-chloroperoxybenzoic acid, the thioether is converted to the sulfoxide structure required here.
Furthermore, the construction of imidazolo [4,5-b] pyridine matrix, or through a multi-step reaction. First, a suitable pyridine derivative and a nitrogen-containing heterocyclic construction reagent are condensed and cyclized under suitable base and temperature conditions to obtain an imidazolo-pyridine skeleton. After that, 5-methoxy groups are introduced at specific positions, which can be achieved by nucleophilic substitution or other functional group conversion reactions.
There are also those who use palladium-catalyzed coupling reactions as key steps. Select a suitable halogenated pyridine derivative and borate esters or other nucleophiles containing imidazolopyridine fragments. In the presence of palladium catalyst, ligand and base, coupling occurs to build a molecular skeleton. After the reaction is completed, the sulfinyl group is introduced and other modifications are carried out to obtain the target product.
The synthesis process requires fine regulation of the reaction conditions, paying attention to the selectivity and yield of each step. Factors such as temperature, solvent, and the proportion of reactants all have a significant impact on the reaction results. And after each step of the reaction, it is necessary to use suitable separation and purification methods, such as column chromatography, recrystallization, etc., to remove impurities and purify, so that the synthesis can be smooth, and pure 5-methoxy-2-{ [ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} -1H-imidazolo [4,5-b] pyridine.
What is the market outlook for 5-Methoxy-2- {[ (4-methoxy-3,5-dimethyl-2-pyridinyl) methyl] sulfinyl} -1H-imidazo [4,5-b] pyridine?
5-Methoxy-2-{ [ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} -1H-imidazolo [4,5-b] pyridine, this is a very important compound, especially in the field of medicine. Its market prospects are like stars in the sky, shining and variable, let me tell you in detail.
Looking at the current pharmaceutical market, there are many patients with digestive diseases, and this compound is often a key ingredient in the treatment of related diseases. As the pace of people's lives accelerates and the pressure increases, the incidence of digestive system diseases is on the rise, so the demand for the drugs involved in this compound also increases. This is one of the positive factors for its market prospects, such as the help of spring breeze, making its market expansion smoother.
However, the road to the market is not smooth. The synthesis process of this compound is slightly complicated and the cost is quite high. And in the market, there are not a few similar competitors. Some competitors have occupied a certain share by virtue of mature technology and market channels. If this compound wants to emerge in the market, it needs to overcome many difficulties, such as going against the current.
However, opportunities and challenges coexist. Advances in scientific research may optimize the synthesis process of this compound, reduce costs, and enhance competitiveness. And with the in-depth research on digestive system diseases, if the unique therapeutic effect of this compound can be tapped, new market space may be opened up.
In summary, the market prospect of 5-methoxy-2 - {[ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} -1H-imidazolo [4,5-b] pyridine is full of hope and thorns. Practitioners need to gain insight into market changes, grasp opportunities and respond to challenges with wisdom and hard work, in order to win the favor of the market and bloom its unique brilliance.
5-Methoxy-2- {[ (4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl} -1H-imidazo [4,5-b] pyridine What are the related drugs or preparations?
5-Methoxy-2-{ [ (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} -1H-imidazolo [4,5-b] pyridine, which is the chemical name of pantoprazole. Pantoprazole-related drugs and preparations are quite common.
Guanvpantoprazole, its preparations are mostly enteric-coated tablets and injections. For enteric-coated tablets, after oral administration, the drug can be soluble in the intestines, which can effectively avoid the damage of gastric acid to the drug and ensure that the drug can reach the intestines smoothly and play an effective role. Clinically, it is often used to treat acid-related diseases such as gastric ulcer, duodenal ulcer, and reflux esophagitis. Gainpantoprazole can specifically act on the proton pump of gastric parietal cells to inhibit gastric acid secretion, thereby relieving various symptoms caused by excessive gastric acid and promoting the healing of the ulcer surface.
As for injections, they are mostly used in situations where the condition is more critical and the secretion of gastric acid is urgently needed. For example, when the upper gastrointestinal tract bleeds, intravenous injection of pantoprazole can rapidly increase the concentration of drugs, effectively inhibit gastric acid, and achieve the purpose of stopping bleeding and protecting the gastric mucosa. In addition, pantoprazole is used in combination with other drugs, and is also commonly used in the eradication treatment of Helicobacter pylori, in coordination with antibiotics, etc., to clear the bacteria and reduce the risk of ulcer recurrence. These are all common drugs and preparations related to 5-methoxy-2 - { (4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl} -1H-imidazolo [4,5-b] pyridine.