5-iodo-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxylic acid Base Information

This is the name of 5-iodine-6-methyl-2-oxo-1 - [3 - (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acid. According to the nomenclature of organic chemistry, in order to clarify its chemical structure, the parts of its name can be analyzed. " 5-Iodine ", showing that there is an iodine atomic phase at the 5th position of the pyridine ring;" 6-methyl ", knowing that the 6th position is connected with a methyl group;" 2-oxo ", Table 2 is carbonyl oxygen;" 1 - [3 - (trifluoromethyl) phenyl] ", Table 1 is connected to a phenyl group containing 3-trifluoromethyl;" 1,2-dihydropyridine ", determining its main body as a dihydropyridine ring;" 3-carboxylic acid ", Ming No. 3 position has a carboxyl group. The main structure of the compound is a dihydropyridine ring with iodine, methyl, and carboxyl groups attached at specific positions, and the No. 1 position is connected to a phenyl group containing trifluoromethyl. In short, this compound is nucleated by a dihydropyridine ring and carries many specific substituents. Its structure can be deduced by the naming convention.

5-Iodine-6-methyl-2-oxo-1 - [3- (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acid, this is an organic compound. Looking at its structure, specific groups such as iodine atom, methyl group, and trifluoromethyl give it unique physical properties.
Regarding its properties, under normal circumstances, it may be a crystalline solid. Due to the interaction of hydrogen bonds and van der Waals forces between molecules, the molecules are arranged in an orderly manner to form a crystalline structure. Its melting point is due to the complexity of the molecular structure or is in a specific temperature range. In the molecule, polar groups and non-polar groups coexist, resulting in their solubility. In polar solvents such as methanol and ethanol, polar groups can form hydrogen bonds with solvent molecules, or have a certain solubility; in non-polar solvents such as n-hexane, the solubility may be very small.
Furthermore, the compound contains a conjugated system composed of a pyridine ring and a phenyl group connected to it. This conjugated system endows it with unique optical properties, or under the irradiation of specific wavelengths of light, it exhibits absorption and emission phenomena, which may have potential applications in the field of optical materials. And carbonyl and carboxyl groups in the molecule are chemically active and can participate in a variety of chemical reactions, such as esterification, amidation, etc., which are also of great significance in the field of organic synthesis.

5-Iodine-6-methyl-2-oxo-1- [3- (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acid, this is an organic compound. Its chemical properties are quite complex, let me tell you in detail.
From a structural point of view, the compound contains a pyridine ring, and there are iodine atoms, methyl groups, carbonyl groups, trifluoromethylphenyl groups, and carboxyl groups attached to the pyridine ring at specific positions.
The introduction of an iodine atom gives the compound a certain nucleophilic substitution activity. Due to the large radius of the iodine atom, the C-I bond energy is relatively low. Under appropriate conditions, the iodine atom is easily replaced by other nucleophilic reagents, resulting in nucleophilic substitution reaction, which is one of its important chemical properties. The existence of
methyl group, because the methyl group is the power supply group, will affect the electron cloud density distribution of the pyridine ring, so that the electron cloud density of the adjacent and para-position of the pyridine ring is relatively increased, resulting in compounds in the electrophilic substitution reaction, the adjacent and para-position are more susceptible to the attack of electrophilic reagents. The properties of
carbonyl groups cannot be ignored. They have a certain polarity, and the oxygen atoms in the carbon-oxygen double bond have strong electronegativity, which makes the carbonyl carbon partially positively charged and vulnerable to the attack of nucleoph
In trifluoromethyl phenyl, trifluoromethyl is a strong electron-withdrawing group, which will reduce the electron cloud density of the whole phenyl group, which in turn affects the electron cloud distribution of the pyridine ring connected to it, and has an effect on the reactivity and selectivity of the compound.
The carboxyl group is acidic and can neutralize with the base to form the corresponding carboxylate. At the same time, the carboxyl group can participate in the esterification reaction and react with the alcohol under acid catalysis to form ester compounds.
In summary, 5-iodine-6-methyl-2-oxo-1- [3- (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acids exhibit diverse chemical properties due to their functional groups, and may have many potential applications in the field of organic synthesis.

5-Iodine-6-methyl-2-oxo-1 - [3 - (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acid, an organic compound. It has a wide range of common uses and is often used as a key intermediate in the field of organic synthesis.
In the field of medicinal chemistry, it may have potential medicinal value. Due to its unique chemical structure, it may be modified or modified to meet the needs of specific drug targets, and then new therapeutic drugs can be developed.
In the field of materials science, it may also have applications. Or by participating in specific reactions, materials with special properties can be constructed, such as optoelectronic materials. Because of its special groups such as iodine and trifluoromethyl, or endow materials with unique optical and electrical properties.
Furthermore, in chemical research, as a model compound, it helps scientists to deeply explore basic chemical problems such as reaction mechanism, structure and performance. Through the study of its reaction characteristics, it can gain insight into the commonalities and characteristics of compounds containing similar structures, laying the foundation for the synthesis and application of more complex compounds. In short, this compound has many uses and research values that cannot be ignored in many chemical-related fields.

The synthesis method of 5-iodine-6-methyl-2-oxo-1-[ 3-trifluoromethyl-phenyl] -1,2-dihydropyridine-3-carboxylic acid can be achieved by various routes. Looking at the past literature, the common method is to use a compound containing a pyridine structure as the starting material.
First, a specific pyridine derivative is used as the base to adjust the alkaline environment of the reaction system before a suitable solvent, such as aprotic solvent acetonitrile or N, N-dimethylformamide (DMF), adding alkali substances, such as potassium carbonate or potassium tert-butyl alcohol. Then, an iodine-containing reagent, such as iodine elemental or iodine hydrocarbons, is added, and the iodine atom is introduced into the specific position of the pyridine ring through a nucleophilic substitution reaction to generate an iodine-containing pyridine intermediate.
Second, for the introduction of methyl groups, methylation reagents such as iodomethane or dimethyl sulfate are often used. Under basic conditions, this reagent reacts with the pyridine intermediate to connect the methyl group to the corresponding check point of the pyridine ring.
Third, a 2-oxo structure is constructed, and an oxidizing agent, such as m-chloroperoxybenzoic acid (m-CPBA) or hydrogen peroxide, can be used to oxidize the specific carbon-hydrogen bond on the pyridine ring to a carbonyl group at an appropriate temperature and reaction time.
Fourth, when the 1 - [3 - (trifluoromethyl) phenyl] structure is introduced, the coupling reaction catalyzed by transition metals is mostly used, such as the Suzuki coupling reaction catalyzed by palladium. Boric acid or borate ester containing trifluoromethylphenyl is used as the reactant, and the pyridine intermediate is heated in a suitable solvent in the presence of palladium catalyst and ligand to achieve the connection of this structure.
The formation of its penta3-carboxylic acid structure is often obtained by hydrolysis of pyridine derivatives containing ester groups. In an alkaline aqueous solution, such as sodium hydroxide or potassium hydroxide solution, the ester group is hydrolyzed into a carboxylic acid group by heating and refluxing, and the final 5-iodine-6-methyl-2-oxo-1- [3 - (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acid. Although this method has its own advantages and disadvantages, it is an effective way to synthesize the compound. Experimenters can choose the best one according to the actual situation.