5-iodo-2-(trifluoromethyl)pyridine

5-Iodine-2- (trifluoromethyl) pyridine is also an organic compound. It has a wide range of uses in the field of medicinal chemistry and is often a key intermediate for the synthesis of many effective drugs. The unique structure of the geinpyridine ring with iodine and trifluoromethyl gives it special chemical activity and properties, and can be combined with other compounds according to specific reaction mechanisms, thus contributing to the creation of new drug molecules.
In the field of pesticide chemistry, it also plays an important role. With its own structural characteristics, pesticides with high insecticidal, bactericidal or herbicidal properties can be prepared. After ingenious design and synthesis, the compound can precisely act on the specific physiological process of the target organism, interfere with its normal growth and reproduction, and achieve the purpose of preventing and controlling harmful organisms.
Furthermore, in the field of materials science, 5-iodine-2 - (trifluoromethyl) pyridine may be used to synthesize materials with special functions. Its unique chemical structure may endow materials with special properties such as excellent photoelectric properties and thermal stability, providing opportunities for the development of new optoelectronic materials and high-performance polymer materials. For example, in the research and development of organic Light Emitting Diode (OLED) materials, or because of its structural properties, the luminous efficiency and stability of materials can be optimized, thereby improving the performance of OLED devices.

5-Iodine-2- (trifluoromethyl) pyridine, an important intermediate in organic synthesis. The synthesis method, as described in the ancient books, is about three.
First, 2 - (trifluoromethyl) pyridine is used as the starting material and obtained by halogenation reaction. First, dissolve 2 - (trifluoromethyl) pyridine in a suitable solvent, such as dichloromethane or chloroform, cool to a low temperature, such as about 0 ° C, and slowly add iodine-containing reagents, such as N-iodosuccinimide (NIS). Add it dropwise, stir at low temperature for a few times, then heat up to room temperature, and continue to stir. After the reaction is completed, it is treated by conventional methods, such as quenching the reaction with water, extracting the organic solvent, drying the organic phase, and removing the solvent by rotary evaporation to obtain a crude product. Purified by column chromatography, pure 5-iodine-2- (trifluoromethyl) pyridine can be obtained.
Second, starting from the pyridine derivative, trifluoromethyl is introduced first, followed by iodine atoms. Trifluoromethyl is introduced by reacting with a suitable pyridine derivative, such as 2-chloropyridine, with a trifluoromethylating agent, such as trifluoromethyl copper-lithium reagent, at low temperature and protected by an inert gas. After the reaction, 2 - (trifluoromethyl) pyridine derivatives are obtained, and then iodine atoms are introduced by pre-halogenation. After similar separation and purification steps, the target product can be obtained.
Third, the coupling reaction catalyzed by transition metals is synthesized. Select suitable halogenated pyridine derivatives, such as 5-bromo-2 - (trifluoromethyl) pyridine, and iodide reagents, and react in appropriate ligands, bases and solvents under the action of transition metal catalysts, such as palladium catalysts. The reaction conditions need to be precisely controlled, such as temperature and reaction time. After the reaction is completed, the product can also be purified by extraction, column chromatography and other means to obtain 5 - iodine-2 - (trifluoromethyl) pyridine.
All synthesis methods have their own advantages and disadvantages, and should be selected carefully depending on factors such as the availability of raw materials, the difficulty of reaction conditions, and the high cost.

5-Iodine-2- (trifluoromethyl) pyridine is also an organic compound. Its physical properties are particularly important and are related to the many uses and characteristics of this substance.
First of all, under room temperature, 5-iodine-2- (trifluoromethyl) pyridine is mostly colorless to light yellow liquid, which is easy to handle and handle in many chemical reactions and industrial applications. Its light color indicates that the characteristics of molecular structure do not lead to significant chromophore formation, and it is also reflected in optical properties.
When it comes to boiling point, it is between 190 and 200 ° C. The value of the boiling point indicates the strength of the intermolecular forces of this compound. A higher boiling point indicates that there are certain interactions between molecules, such as van der Waals forces, dipole-dipole interactions, etc. This property is of guiding significance in separation, purification and control of reaction conditions.
In terms of melting point, it is about -20 ° C. The lower melting point keeps the substance in a liquid state at room temperature, which is conducive to mixing, dissolution and participation in various homogeneous reactions. The density of
is about 1.9 g/cm ³. This value shows that it is denser than water. In reaction systems involving liquid-liquid separation or water-related reactions, the substance will be in the lower layer. This property is critical for reaction operation and product separation.
Solubility is also an important property. 5-Iodine-2 - (trifluoromethyl) pyridine is soluble in common organic solvents such as dichloromethane, chloroform, toluene, etc., but the solubility in water is very small. This difference in solubility is based on its molecular structure. The groups containing fluorine and iodine make it hydrophobic to a certain extent, while the pyridine ring has a certain polarity, but it is not sufficient to make it highly soluble in water. The good solubility of organic solvents facilitates the selection of reaction media in organic synthesis, allowing the reactants to be fully mixed and improving the reaction efficiency.

5-Iodine-2- (trifluoromethyl) pyridine is also an organic compound. Its chemical properties are quite interesting, and this is for you to describe in detail.
In this compound, the iodine atom has the activity of nucleophilic substitution reaction. The cover iodine atom has a large radius and the bond energy of the C-I bond is relatively small, so it is easy to leave. When nucleophilic reagents, such as alkoxides and amines, can undergo nucleophilic substitution to form new C-O or C-N bonds.
Furthermore, the existence of trifluoromethyl groups has a significant impact on the distribution of electron clouds in the pyridine ring. Trifluoromethyl has strong electron-absorbing properties, which decreases the electron cloud density on the pyridine ring, especially the electron cloud density at positions 3, 4, and 6. This results in a decrease in the electrophilic substitution reactivity of the pyridine ring, and the reaction check point tends to be at position 3.
For redox reactions, 5-iodine-2 - (trifluoromethyl) pyridine may participate in oxidation reactions. Iodine atoms may be oxidized to higher valence states, and pyridine rings may also undergo ring-opening reactions due to the strong oxidation of oxidants. In reduction reactions, the unsaturated bonds of the pyridine ring may be reduced, and if a suitable reducing agent is used, the pyridine ring can be partially hydrogenated.
In addition, its reaction with metal-organic reagents is also worthy of attention. If it interacts with Grignard reagents or lithium reagents, new hydrocarbon groups and other groups can be introduced into the pyridine ring, thereby deriving more complex organic compounds.
To be sure, 5-iodine-2 - (trifluoromethyl) pyridine has diverse chemical properties due to its unique structure, and has many potential applications in the field of organic synthesis.

What I'm asking you is what the price of 5-iodine-2- (trifluoromethyl) pyridine is in the market. However, the price of this chemical often changes for a variety of reasons, making it difficult to generalize.
First, the producers are different, and the price may be different. Different producers have different production methods and costs. Those with high technology and low cost may be slightly cheaper; conversely, the price may be slightly higher.
Second, the amount of quantity also affects the price. If the purchase volume is huge, the producer may give a discount due to the thought of small profits but quick turnover, and the price can be reduced; if the purchase quantity is small, the price may continue as usual.
Third, the supply and demand of the city determines the price. If there are many applicants and few suppliers, the price will rise; if the supply exceeds the demand, the price may fall.
There are multiple transportation, packaging and other fees, which are also involved in the total price. For long-distance transportation, the fee will increase, and the price will follow; for exquisite packaging, the cost will increase, and the price may be slightly higher.
In my opinion, if you want to know the exact price, you can go to the chemical product trading platform, such as Gade Chemical Network, Mobi.com, etc., to check the quotations of various merchants; you can also directly consult the chemical raw material supplier and inform them of the required quantity.